Liquid-phase automatic synthesizer

Abstract

The invention relates to a liquid-phase automatic synthesizer. The automatic liquid phase synthesizer is provided with an automatic sample injection system, a liquid phase synthesis auxiliary system, an automatic liquid phase synthesis monitoring system and an upper computer, so that the automatic sample injection system completes automatic sample injection operation according to a sample injection instruction of the upper computer; and the liquid phase synthesis auxiliary system completes temperature and illumination control of a to-be-reacted solution according to a temperature control instruction and an illumination control instruction of the upper computer, the automatic monitoring system monitors the reaction solution and generates a monitoring report, and the upper computer generates an experiment analysis result according to the monitoring report. Therefore, the automatic process from sample injection to report generation in the liquid phase experiment process is completed, the experiment labor cost is reduced, and the experiment efficiency is improved.

Description

technical field [0001] The invention relates to the technical field of experimental equipment, in particular to a liquid-phase automatic synthesizer. Background technique [0002] Liquid phase experiments are an indispensable part of academic research. Existing liquid-phase experiments all require manual quantitative addition of the fusion to be reacted, and the mixed solution is obtained by manually controlling the stirring reaction. In the process of detecting the mixed solution, it is also necessary to manually add the reaction solution to the monitor for detection, and the monitoring report generated by the monitor needs to be manually checked, which makes the entire liquid phase experiment monitoring process time-consuming and laborious. [0003] Based on this, some automatic sampling devices are provided in the prior art, and the sampling methods mainly include two types: 1. Pipeline transfer sampling: currently there are peptide solid-phase synthesizers, oligosacchar...

AI Technical Summary

Problems solved by technology

Its advantages are airtight system, safety, no external interference and strong system; the disadvantage is that the research and development cycle is long, and the design and development cost of a single finished product is high.

There are two ways to design it: 1. Components are purchased and assembled, which can be flexibly adjusted and modified to facilitate integrated procedures (syringe pump unit, multi-channel switching valve, light source, low temperature cycle, magnetic stirring, etc., and on-line monitoring), but it also requires Redesign, long cycle, requires talents from various fields, and there are many factors affecting the operation results after assembly

2. Retrofitting and upgrading from commercialized similar products, that is, properly transforming mature automation products, the cycle is short and does not require too much manpower, and normal work can be guaranteed. However, because mature products have mature software control systems developed by their own patents, program integration is troublesome , without source code, may require board redesign

This method is easy to control the temperature and is stable. The synthesis effect of the model reaction is the same as the previous side-illumination method in the laboratory, or even slightly better, but it still needs to cool down the cold trap and open the low-temperature circulation device of the cold trap. It is not easy to assemble the instrument and is not safe. And the utilization rate of ultraviolet light is very low, and additional ultraviolet protection devices are required

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