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Method for reducing hepatotoxicity of fructus psoraleae

A technology of psoralen and hepatotoxicity, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., and can solve problems such as liver damage

Inactive Publication Date: 2021-04-20
北京圆融科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(Reference Nam SW, Baek JT, Lee DS, et al. A Case of Acute Cholestatic Hepatitis Associated with the Seeds of Psoralea corylifolia (Boh-Gol-Zhee) [J]. Clin Toxicol, 2005, 43: 589-591.) At present, the processing method of psoralen is mainly salt-burning method, but there are also cases of liver damage caused by salt psoralen clinically, which shows that salt-burning psoralen still has certain liver toxicity (Wang Yueqing, He Dengming. A case of drug-induced liver injury and literature review [J]. Journal of Practical Medicine, 2018, 35(08): 724-725.), suggesting that the main purpose of salt-burning method is to change the medicine and meridian distribution to enhance the efficacy of the medicine, not to reduce the toxicity
In addition, there are also related companies that use boiling water to detoxify psoraleae, but there are still cases of liver injury in clinical practice.

Method used

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  • Method for reducing hepatotoxicity of fructus psoraleae
  • Method for reducing hepatotoxicity of fructus psoraleae
  • Method for reducing hepatotoxicity of fructus psoraleae

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1 The preparation of psoraleae different repair products

[0062] a. The methods of this application include:

[0063] Pretreatment: the psoralen is soaked in ethanol aqueous solution, rinsed with water in sequence, and then the rinsed psoralen is steamed and dried.

[0064] According to the concentration and consumption of the aqueous ethanol solution in Table 1, the soaking time, the number of times of soaking and the consumption of water, the rinsing time, the number of times of rinsing, and the steaming conditions, psoraleae were processed; the steamed psoralen was dried in the sun for 3 days .

[0065] Table 1: Psoralen pretreatment conditions

[0066]

[0067] b. Preparation of psoralen repair products

[0068] Take about 100g of each psoralen medicinal material, and prepare psoralen X1, X2, and X3 repair products according to the method in a.

Embodiment 2

[0069] Example 2 Cell Experiment Evaluation of the Toxicity of Psoralen

[0070] a. Prepare different repair products for the test solution;

[0071] Take 20g of psoralea repair products (X1, X2, X3) respectively, accurately weigh them, place them in conical flasks, add ethanol with a volume fraction 10 times that of psoralen medicinal materials and a volume fraction of 75%, and ultrasonically (40KHz, 500W ) extraction, a total of 3 extractions, 1 hour each time, filtered with eight layers of gauze, combined the filtrates, concentrated under reduced pressure on a rotary evaporator to recover ethanol, and obtained a thick extract of psoraleae repair products, and prepared freeze-dried powder on a freeze dryer for future use. Take the lyophilized powder (X1, X2, X3) respectively and use William's E cell culture medium to prepare mass concentration fractions of 0.5mg (crude drug) mL -1 , 1mg (crude drug) mL -1 , 2mg (crude drug) mL -1 , 4mg (crude drug) mL -1 The medicinal so...

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Abstract

The invention discloses a method for reducing hepatotoxicity of fructus psoraleae. The method comprises the following steps that the fructus psoraleae is pre-treated, the fructus psoraleae is sequentially soaked with an ethanol water solution and rinsed with water, and then the fructus psoraleae rinsed with water is steamed and dried. The fructus psoraleae prepared by the method can effectively reduce the hepatotoxicity of the fructus psoraleae and does not affect the efficacy of the fructus psoraleae.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine safety, in particular to a method for reducing hepatotoxicity of psoraleae. Background technique [0002] Psoralen is the dried and mature fruit of Psoralea corylifolia L., a leguminous plant. Now it is clinically treating lumbar and knee pain, osteoporosis, fractures, osteoarthritis, etc. In recent years, with the widespread use of psoraleae and its preparations, the reports of adverse reactions of psoralen and its preparations on liver injury are increasing at home and abroad, and its safety issues have attracted widespread attention at home and abroad. The State Food and Drug Administration has successively notified the risk of liver damage caused by preparations containing psoralen (Zhuanggu Joint Pills, Xianling Gubao, Gukang Capsules). and its preparations were included. Clinical cases have shown that psoralen alone has certain hepatotoxicity. (Reference Nam SW, Baek JT, Lee D...

Claims

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Application Information

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IPC IPC(8): A61K36/487A61K131/00
Inventor 马永刚
Owner 北京圆融科技有限公司
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