Clinical application of oxytocin injection to pregnant women with hypertension

A technology of pregnancy-induced hypertension and clinical application, applied in the field of oxytocin injection

Inactive Publication Date: 2021-04-20
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to provide the clinical application of oxytocin injection in puerpera with gestational hypertension, to solve the problem of whether to consider the specificity of the application of oxytocin when using oxytocin in puerpera with gestational hypertension, and whether there is any difference with normal puerpera

Method used

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  • Clinical application of oxytocin injection to pregnant women with hypertension

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] see figure 1 , the clinical application of oxytocin injection in pregnant women with hypertensive pregnancy, isolating the placental uterine blood vessels of normal pregnancy and pregnant women with hypertensive pregnancy, detecting the contractile response of blood vessels to different doses of oxytocin, and quantitatively analyzing blood vessels and plasma Expression of oxytocin receptors.

[0021] see figure 1 , The effect of the drug on the contraction of the uteroplacenta before, during and after use.

[0022] see figure 1 , the maximum contraction strength that oxytocin can cause to the uteroplacenta.

[0023] see figure 1 , Oxytocin Mediates Uteroplacental Contraction Sensitivity.

[0024] see figure 1 , Application of oxytocin receptor expression in uteroplacenta.

[0025] see figure 1 , the same content of oxytocin in plasma.

[0026] see figure 1 , oxytocin dosage 10 -8 to 10 -4 mol / L.

[0027] see figure 1 , the amount of oxytocin gradually incr...

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Abstract

The invention discloses a clinical application of an oxytocin injection to pregnant women with hypertension. Placenta uterine surface blood vessels of normal pregnant women are separated from those of the pregnant women with hypertension, systolic reaction of the blood vessels to oxytocin of different doses is detected, and expression conditions of oxytocin receptors in the blood vessels and blood plasma are quantitatively analyzed. The research has an important guiding effect and significance in the aspect of the clinical application of the oxytocin injection to the pregnant women with hypertension, for the pregnant women with hypertension, no matter whether the oxytocin is used for prenatal uterine contraction promotion and parturition induction or used for prevention of cesarean delivery postnatal bleeding, paying attention to the application dosage of the oxytocin, considering individualized differences and adjusting the dosage in time are a key for ensuring the effective and safe application of the oxytocin.

Description

technical field [0001] The invention belongs to the technical field of oxytocin injection, in particular to the clinical application of oxytocin injection in pregnant women with hypertension. Background technique [0002] Oxytocin, also known as oxytocin, is a main component of pituitary hormone. Oxytocin is a polypeptide substance composed of 8 amino acids, which can selectively excite uterine smooth muscle and cause rhythmic contraction of uterine placenta. Oxytocin acts on the uterus by binding to oxytocin receptors. [0003] As a classic uterine uterine drug in the field of obstetrics, oxytocin is widely used to induce labor, induce labor, prevent and treat postpartum hemorrhage, and postpartum uterine atony. It is widely used during normal and pregnancy complications during pregnancy and childbirth. [0004] In recent years, the incidence of hypertensive disorders in pregnancy (PIH) has gradually increased, accounting for 5% to 10% of pregnant women. Pregnancy-induce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/095A61K9/08A61P15/04A61P7/04
Inventor 高芹芹孙淼徐智策李凌君汤佳奇
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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