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Pure natural high stability polymethoxyflavonoid nanoemulsion and its preparation and application

A polymethoxyflavonoid, high stability technology, applied in the field of polymethoxyflavonoid nanoemulsion, can solve the problem of no proof of emulsion stability, and achieve the effects of simple and efficient production process, stable emulsion, and easy mass production

Active Publication Date: 2022-08-09
HANGZHOU NUOSHEN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] 3) There is no proof of the stability of the emulsion formed by the microcapsule powder after being dissolved in water

Method used

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  • Pure natural high stability polymethoxyflavonoid nanoemulsion and its preparation and application
  • Pure natural high stability polymethoxyflavonoid nanoemulsion and its preparation and application
  • Pure natural high stability polymethoxyflavonoid nanoemulsion and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The pure natural high-stability polymethoxyflavonoid nanoemulsion of the present embodiment is made from the raw materials of the following mass ratios:

[0056]

[0057] The preparation method of the pure natural high-stability polymethoxyflavonoid nanoemulsion of the present embodiment comprises the steps:

[0058] (1) Dissolve 20 g of chenolidein in 20 g of olive oil and 10 g of sunflower oil to obtain an oil phase.

[0059] (2) 20 g of gum arabic, 40 g of polyglycerol-4 caprylate and 10 g of polyglycerol-4 laurate were dissolved in 880 g of deionized water to obtain an aqueous phase.

[0060] (3) the oil phase obtained in step (1) and the water phase obtained in step (2) are mixed and stirred to obtain a mixed solution;

[0061] (4) using an ultrasonic generator (ultrasonic processor) to process the mixed solution at room temperature for about 5 minutes until the mixed solution becomes a stable emulsion and the viscosity is no longer reduced, that is, a pure nat...

Embodiment 2

[0064] The pure natural high-stability polymethoxyflavonoid nanoemulsion of the present embodiment is made from the raw materials of the following mass ratios:

[0065]

[0066]

[0067] The preparation method of the pure natural high-stability polymethoxyflavonoid nanoemulsion of the present embodiment comprises the steps:

[0068] (1) Dissolve 30 g of tangerine peelin, 20 g of orange peelin, and 20 g of orange flavonoids in 70 g of almond oil to obtain an oil phase.

[0069] (2) 30 g of gum arabic, 60 g of polyglycerol-10 caprylate and 50 g of polyglycerol-10 caprylate were dissolved in 720 g of deionized water to obtain an aqueous phase.

[0070] (3) the oil phase obtained in step (1) and the water phase obtained in step (2) are mixed and stirred to obtain a mixed solution;

[0071] (4) use an ultrasonic generator (ultrasonic processor) to process the mixed solution at room temperature for 3 to 5 minutes until the mixed solution becomes a stable emulsion and the visc...

Embodiment 3

[0074] The nanoemulsions prepared in the above examples 1 and 2 are respectively spray-dried at 60-200° C. to obtain the microcapsule powder of the corresponding formula.

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Abstract

The invention discloses a pure natural high-stability polymethoxyflavonoid nano-emulsion and its preparation and application. The nanoemulsion comprises the following raw materials by mass percentage: 5-20% of polymethoxyflavonoid / natural oil mixture, 2-10% of emulsion stabilizer, 2-20% of non-ionic emulsifier, and the balance of deionized water; The mass sum of the components is 100%. Preparation method: mixing polymethoxyflavone and natural oil in proportion to obtain a polymethoxyflavonoid / natural oil mixture; dissolving an emulsion stabilizer and a nonionic emulsifier in deionized water to obtain a water phase; The base flavonoid / natural oil mixture and the water phase are mixed uniformly to obtain a mixed liquid; the mixed liquid is treated with a high-pressure homogenizer or an ultrasonic generator until the mixed liquid becomes a stable emulsion and the viscosity is no longer reduced. The pure natural high-stability polymethoxyflavonoid nanoemulsion of the present invention can be directly or indirectly widely used in food, health care products, medicines, cosmetics and the like.

Description

technical field [0001] The invention relates to the field of polymethoxyflavone nanoemulsion, in particular to a pure natural high stability polymethoxyflavone nanoemulsion and its preparation and application. Background technique [0002] Polymethoxylated flavonoids (PMFs) are a unique class of flavonoids in citrus fruits, which exist in the form of free aglycones and have a planar structure. The chemical structural formula of flavonoids is as follows: [0003] [0004] When four or more H functional groups are substituted with methoxy groups, it is a polymethoxyflavonoid. [0005] Nobiletin and tangeretin are the main polymethoxyflavonoids in citrus peels. Other polymethoxyflavonoids in citrus peels include 5-demethylnobiletin, 5-demethyltangeretin, orange flavonoids (5,6,7, 3',4'-Pentamethoxyflavone, Sinensetin), Isoflavone (3',4',5,7,8-Pentamethoxyflavone, isosinensetin), 5,6,7,4'-tetra Methoxyflavones (5,6,7,4'-tetramethxyflavone), 3,5,6,7,3',4'-hexamethoxyflavon...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/92A61K8/49A61K8/06A61Q19/08A61K9/107A61K31/352A61P39/06A61P35/00A61P29/00A61P31/12A23L33/105A23L33/115A23L29/10A23L29/25
CPCA61K8/922A61K8/498A61K8/068A61Q19/08A61K9/1075A61K31/352A61P39/06A61P35/00A61P29/00A61P31/12A23L33/105A23L33/115A23L29/10A23L29/25A23V2002/00A23V2250/21162A23V2250/2116A23V2250/18A23V2250/5028A23V2200/222Y02A50/30
Inventor 李骏秦旭汤小苏
Owner HANGZHOU NUOSHEN TECH CO LTD