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Child cough liquid specific chromatogram, construction method thereof and child cough liquid quality detection method

A feature map and construction method technology, applied in the field of traditional Chinese medicine detection, can solve the problem of incomplete quality detection of children's cough liquid products

Active Publication Date: 2021-04-30
TONG REN TANG TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned documents mainly focus on the research and establishment of thin-layer identification and content determination methods of children's cough liquid. At present, there are no relevant research reports on the establishment of fingerprint or characteristic map methods, resulting in problems such as incomplete quality testing of children's cough liquid products. The quality standard of children's cough liquid to be further improved

Method used

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  • Child cough liquid specific chromatogram, construction method thereof and child cough liquid quality detection method
  • Child cough liquid specific chromatogram, construction method thereof and child cough liquid quality detection method
  • Child cough liquid specific chromatogram, construction method thereof and child cough liquid quality detection method

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Effect test

Embodiment 1

[0088] This embodiment provides a method for constructing a characteristic map of cough fluid in children, comprising the following steps:

[0089] Preparation of test solution A: Accurately measure 1ml of 11 batches of children's cough liquid samples, put them in a 5ml measuring bottle, add methanol to the mark, shake well, filter with a filter membrane with a pore size of 0.45um, take the continuation Filtrate, obtain the need testing solution A of each sample;

[0090] Preparation of the reference solution: Take an appropriate amount of amygdalin, liquiritin, and proscetidin reference substances, weigh them accurately, add methanol to make a mixed solution containing 0.2 mg of amygdalin, 20 μg of liquiritin, and 10 μg of proseridin per 1 ml. Shake well to obtain the reference substance solution;

[0091] Determination: Draw up 10 μl of the reference substance solution of the reference substance, the test substance solution A of 11 samples, and the test substance solution B...

Embodiment 2

[0097] This embodiment provides a method for constructing a characteristic map of children's cough liquid, which is used for quality inspection of children's cough liquid products, including the following steps:

[0098] Preparation of the test solution: Accurately measure 1ml of the child's cough liquid sample to be tested, put it in a 5ml measuring bottle, add methanol to the mark, shake well, filter with a filter membrane with a pore size of 0.45um, and take the subsequent filtrate, namely have to;

[0099] Test: Draw 8 μl of the reference substance reference solution and the test solution respectively, inject them into the liquid chromatograph, measure, and obtain the characteristic spectrum of the cough liquid of the child to be tested, wherein, the characteristic spectrum of the cough fluid of the child to be tested is as follows: Figure 4 shown. The chromatographic conditions are as follows: use octadecylsilane bonded silica gel as filler, select Agilent ZORBAX SB-C18...

Embodiment 3

[0102] This embodiment provides a method for constructing a characteristic map of cough fluid in children, comprising the following steps:

[0103] Preparation of the test solution: Accurately measure 1ml of the child's cough liquid sample to be tested, put it in a 5ml measuring bottle, add methanol to the mark, shake well, filter with a filter membrane with a pore size of 0.45um, and take the subsequent filtrate, namely have to;

[0104] Preparation of the reference solution: Take an appropriate amount of amygdalin, liquiritin, and proscetidin reference substances, weigh them accurately, add methanol to make a mixed solution containing 0.2 mg of amygdalin, 20 μg of liquiritin, and 10 μg of proseridin per 1 ml. Shake well to obtain the reference substance solution;

[0105] Test: Draw 10 μl of the reference substance solution of the reference substance and the solution of the test substance respectively, inject it into the liquid chromatograph, measure, and obtain the charact...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine detection, and particularly provides a child cough liquid specific chromatogram, a construction method thereof and a child cough liquid quality detection method. In the construction method of the child cough liquid specific chromatogram, the child cough liquid specific chromatogram is established by controlling liquid chromatography conditions, mobile phase composition and an elution program, and eight common specific peaks are obtained. Chromatographic peaks of the specific chromatogram are completely presented, the uniformity is good, the separation degree of the specific chromatogram peaks is good, the types and the number of chemical components contained in the child cough liquid are comprehensively reflected, overall description and evaluation of the quality of the child cough liquid are achieved, and the effectiveness and the safety of the child cough liquid are guaranteed. The specific chromatogram detection method has the advantages of being simple and convenient to operate, stable, reliable, high in precision, good in reproducibility, easy to master and the like.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine detection, and in particular relates to a children's cough liquid characteristic map and a construction method thereof, and a quality detection method of children's cough liquid. Background technique [0002] Children's Cough Liquid is a traditional Chinese medicine preparation, which is an over-the-counter drug. It has the effects of clearing away heat and moistening the lungs, reducing lung qi, eliminating phlegm and relieving cough. Acute and chronic bronchitis. [0003] With the enhancement of people's awareness of health care, people have higher requirements for the quality and safety of Chinese patent medicine products. The current standard for children's cough liquid is the drug standard of the Ministry of Health of the People's Republic of China (preparation of traditional Chinese medicine), which only includes simple properties, TLC identification, routine inspection...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/34G01N30/74G01N30/86G01N30/06G01N30/14
CPCG01N30/02G01N30/34G01N30/74G01N30/8686G01N30/8634G01N30/8679G01N30/06G01N30/14G01N2030/146Y02A50/30
Inventor 姚璐赵书武王淑英李晚婧李铮
Owner TONG REN TANG TECH CO LTD
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