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A kind of chitin nanofiber porous composite microsphere blood ammonia adsorbent, its preparation method and application

A technology of porous composite microspheres and nanofibers, which is applied in the field of natural polymer biomedical materials, can solve problems such as clogging, poor operability, and easy leakage, and achieve simple and controllable preparation processes, low cost, and high adsorption efficiency. Effect

Active Publication Date: 2022-07-19
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Zeolite has porosity, sieving, ion exchange, acid resistance and strong binding to water. Although it has a strong selective adsorption capacity for ammonia nitrogen, its biocompatibility and blood compatibility need to be improved before it can be applied. In hemoperfusion, although powder or granular zeolite can efficiently remove ammonia nitrogen, its operability is poor, and it is easy to leak during use and cause blockage. Therefore, it is urgent to find an efficient, simple and practical method that can improve the operability of zeolite. The modification method of property and stability, in order to facilitate its application in hemoperfusion to remove blood ammonia

Method used

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  • A kind of chitin nanofiber porous composite microsphere blood ammonia adsorbent, its preparation method and application
  • A kind of chitin nanofiber porous composite microsphere blood ammonia adsorbent, its preparation method and application
  • A kind of chitin nanofiber porous composite microsphere blood ammonia adsorbent, its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0051] Example 1 Preparation of chitin / zeolite nanofiber porous composite microspheres

[0052] The preparation method of chitin / NaOH / urea aqueous solution is the prior art, and is used according to the method disclosed in ZL200310111566.3. Disperse 5g chitin powder in 95g NaOH / urea aqueous solution and stir for 10min (NaOH:urea=11:4), freeze at -35°C for 4 hours, and then stir and thaw under ice bath. After 3 cycles of freezing / thawing, a clear and transparent chitin solution with a concentration of 5% by weight was obtained, and the chitin solution was centrifuged for 10 min at 4°C and 7000 rad / min, defoamed and removed undissolved impurities to obtain The mass percentage is 5% chitin solution, 0 ℃ for use. The natural zeolite is pulverized with a high-speed pulverizer or a high-speed ball mill, and passed through a 100-mesh sieve for use. 2.5 g of sieved zeolite was added to 100 g of chitin solution, and stirred under an ice bath to obtain a chitin / zeolite composite solut...

Embodiment 2

[0053] Example 2 Preparation of chitin / zeolite nanofiber porous composite microspheres

[0054] The preparation method of chitin / NaOH / urea aqueous solution is the prior art, and is used according to the method disclosed in ZL200310111566.3. Disperse 5g chitin powder in 95g NaOH / urea aqueous solution and stir for 10min (NaOH:urea=11:4), freeze at -35°C for 4 hours, and then stir and thaw under ice bath. After 3 cycles of freezing / thawing, a clear and transparent chitin solution with a concentration of 5% by weight was obtained, and the chitin solution was centrifuged for 10 min at 4°C and 7000 rad / min, defoamed and removed undissolved impurities to obtain 5% chitin solution, 0 ℃ for use. The natural zeolite is pulverized with a high-speed pulverizer or a high-speed ball mill, and passed through a 100-mesh sieve for use. 5 g of sieved zeolite was added to 100 g of chitin solution, and stirred under an ice bath to obtain a chitin / zeolite composite solution, which was used at 0°...

Embodiment 3

[0055] Example 3 Preparation of chitin / zeolite nanofiber porous composite microspheres

[0056] The preparation method of chitin / NaOH / urea aqueous solution is the prior art, and is used according to the method disclosed in ZL200310111566.3. Disperse 5g chitin powder in 95g NaOH / urea aqueous solution and stir for 10min (NaOH:urea=11:4), freeze at -35°C for 4 hours, and then stir and thaw under ice bath. After 3 cycles of freezing / thawing, a clear and transparent chitin solution with a concentration of 5% by weight was obtained, and the chitin solution was centrifuged for 10 min at 4°C and 7000 rad / min, defoamed and removed undissolved impurities to obtain The mass percentage is 5% chitin solution, 0 ℃ for use. The natural zeolite is pulverized with a high-speed pulverizer or a high-speed ball mill, and passed through a 100-mesh sieve for use. 7.5 g of sieved zeolite was added to 100 g of chitin solution, and stirred under an ice bath to obtain a chitin / zeolite composite solut...

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Abstract

The invention belongs to the field of natural polymer biomedical materials, and particularly relates to a chitin nanofiber porous composite microsphere blood ammonia adsorbent, a preparation method and application thereof. The adsorbent is a porous network microsphere composed of chitin nanofibers and zeolite, and the zeolite is wrapped in the chitin nanofiber porous network microsphere. 2~40nm, the most probable pore distribution is 5~15nm, and the specific surface area is 100~500m 2 / g, the diameter of the chitin nanofibers is 10-50 nm, the particle size of the zeolite is 0.01-50 μm, and the content of the zeolite is 1%-50%. The adsorbent of the invention has a multi-scale and multi-layered nanofiber network structure and abundant through-hole channels suitable for the free diffusion of blood ammonia, has good biocompatibility and blood compatibility, and has good adsorption to blood ammonia Effect.

Description

technical field [0001] The invention belongs to the field of natural polymer biomedical materials, in particular to a chitin nanofiber porous composite microsphere blood ammonia adsorbent, a preparation method and application thereof. Background technique [0002] Hepatic Encephalopathy (HE) is a central nervous system dysfunction syndrome caused by liver dysfunction or disorder in patients with severe acute and chronic liver failure. Neurological and psychiatric symptoms such as personality change, disturbance of consciousness and coma are common complications and important causes of death in patients with severe acute and chronic liver disease. Currently, there is no effective treatment, so HE has a poor prognosis and a high mortality rate. The current research shows that the pathogenesis of HE is the result of complex and comprehensive effects of multiple factors, involving metabolic abnormalities of multiple substances, among which ammonia poisoning is an important facto...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/24B01J20/28B01J20/30C02F1/28B01D15/00A61M1/36
CPCB01J20/24B01J20/186B01J20/28004B01J20/28016B01J20/28083B01J20/28061B01J20/28088B01J20/28023C02F1/286C02F1/281B01D15/00A61M1/3679A61M2207/00
Inventor 叶啟发吴双泉陈彪王伟钟自彪王彦峰
Owner WUHAN UNIV
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