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Preparation method and application of novel two-dimensional structure copper metal complex

A two-dimensional structure, copper complex technology, applied in the direction of active ingredients of heavy metal compounds, copper organic compounds, 1/11 group organic compounds without C-metal bonds, etc., can solve problems such as limiting clinical applications

Active Publication Date: 2021-05-18
GUANGXI NORMAL UNIV FOR NATITIES
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional platinum-based drugs have certain side effects, such as nephrotoxicity and ototoxicity, which limit their clinical application

Method used

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  • Preparation method and application of novel two-dimensional structure copper metal complex
  • Preparation method and application of novel two-dimensional structure copper metal complex
  • Preparation method and application of novel two-dimensional structure copper metal complex

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preparation example Construction

[0029]The present invention also provides embodiments of the preparation method of the new two-dimensional structure copper complex, including the steps of: 2-4-dichlorophenoxycetic acid, 2-amino-6-methoxybenzothiazole in solvent The mixed solution, the copper nitrate was also dissolved in the solvent, stirred, and the copper nitrate solution droplets were added to the mixed solution, and the solution was yellow and green, and the room temperature was allowed to stand at room temperature to obtain a light blue block crystal.

[0030]In order to sufficiently react with the ligand feed, the target complex is preferably obtained, preferably the molar ratio of 2,4-dichlorobenzoxoacetic acid, 2-amino-6-methoxybenzothiazole, and three hydroxisitrate copies of 4-5 : 1-2:1.

[0031]In the present invention, as is preferred, the dripping rate of the copper nitrate solution is 1.0-1.5 ml / min, and the time the reaction is reacted at room temperature for 20-60 min. The standing time is 5-10 days at...

Embodiment 1

[0036]Synthesis of complex: 2,4-dichlorobenzoxic acid (0.40 mmol) and 2-amino-6-methoxybenzothiazole (0.10 mmol) were dissolved in 5 ml of methanol, and three sulfur glycol (0.10 mmol) With 10 ml of methanol, stirring, the copper-nitrate solution was added to a mixed solution at a mixed solution at a mixed solution, and the solution was stirred at room temperature for 20 min, and the pale blue block crystal was precipitated at room temperature. .

Embodiment 2

[0038]Synthesis of complex: 2,4-dichlorobenzoxic acid (0.45 mmol) and 2-amino-6-methoxybenzothiazole (0.15 mmol) were dissolved in 5 ml of methanol, three-squeezable (0.10 mmol) With 10 ml of methanol, stirring, a copper-nitrate solution was added to a mixed solution at 1.2 ml / min, and the solution was yellow and green, and the reaction was stirred at room temperature for 40 min, and at room temperature for about 7 days, precipitated light blue block crystals .

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Abstract

The invention provides a novel two-dimensional structure copper complex with anticancer activity as well as a preparation method and application thereof, and belongs to the technical field of medicine synthesis. The molecular formula of the complex is C18H16Cl4CuO8, and the molecular weight of the complex is 565.65. The complex belongs to a P21 / c space group of a monoclinic system. The cell parameters of the complex are as follows: a is equal to 18.9840 (9) nm; b is equal to 7.4920 (4) nm; c is equal to 8.0622 (4) nm; alpha is 90 degrees; beta is 100.986 (5) degrees; and gamma is 90 degrees. The preparation method of the complex comprises the following steps of: dissolving 2, 4-dichlorphenoxyacetic acid and 2-amino-6-methoxybenzothiazole in a solvent to prepare a mixed solution; dissolving copper nitrate in the solvent; dropwise adding the copper nitrate solution into the mixed solution while performing stirring until the solution is yellow green; performing a reaction at room temperature for a period of time; performing still standing at room temperature, so as to obtain light blue blocky crystals. The copper complex provided by the invention has good anticancer activity, and has the advantages of simple process, low cost, good repeatability and the like.

Description

Technical field[0001]The present invention relates to the field of pharmaceutical synthesis, and more particularly to a new two-dimensional structure copper complex having anti-cancer activity, a preparation method and a use.Background technique[0002]Copper is the necessary life element in the human body, which acts as a multi-life process in the body as a structure and catalytic auxiliary factor, and its complex has a regulated coordination configuration in an oxidative environment, which can be better in the cell level. Util, the copper coordination can be used as a basic structural unit of pharmaceutical molecules, especially anti-tumor drug molecules. Phenoxyacetate compounds have better physiological activity, which are widely used in the fields of pesticides, medicine. In recent years, the phenoxic acid complex has caused people's widespread concern due to its interesting topology, photoelectric properties and potential applications in biological applications.[0003]Conventiona...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F1/08A61P35/00A61K31/30
CPCC07F1/005A61P35/00C07B2200/13
Inventor 曾振芳韦友欢蔡杰慧郑广进黄秋萍李致宝张海全韦仕峥
Owner GUANGXI NORMAL UNIV FOR NATITIES
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