A low-temperature electrospray ionization device and mass spectrometry detection method

Abstract

The invention provides a low-temperature electrospray ionization device, which includes an atomized gas cylinder, an ionization chamber provided with an electrospray ionization source, a pipeline network is provided between the atomized gas cylinder and the electrospray ionization chamber, and the pipeline network It includes gas cylinder gas supply pipe, temperature regulating pipe, first branch pipe and second branch pipe connected in parallel between the gas cylinder gas supply pipe and temperature regulating pipe; the gas outlet of the atomizing gas cylinder is connected to one end of the gas cylinder gas supply pipe, The other end of the gas supply pipeline is connected to the first branch pipe and the second branch pipe through a three-way valve and a mass flow meter. The second branch pipe is at least partly installed in the cooling device, and the gas outlet ends of the first branch pipe and the second branch pipe are connected to the temperature regulating pipe. The inlet end of the thermostat tube is provided with a temperature measuring device, and the outlet end of the thermostat tube is connected to the electrospray ionization chamber. The low-temperature electrospray ionization device can obtain molecular ion peaks of thermally unstable compounds, supramolecular compounds formed by weak force, and metal complexes combined with weak coordination bonds, which is convenient for qualitative analysis by mass spectrometry.

Description

technical field [0001] The invention relates to the technical field of mass spectrometry detection, and more specifically, to a low-temperature electrospray ionization device and a mass spectrometry detection method. Background technique [0002] Mass spectrometry can be used to qualitatively analyze the composition information of the unknown compound to be tested, and obtaining the molecular ion peak of the unknown compound to be tested is a prerequisite for qualitatively analyzing its chemical composition information. The Emergence of Electrospray Ionization Source (ESI) [1] , which solves the problem that most compounds are fragmented into fragment ions due to too high ionization energy during ionization to form charged ions, and expands the application range of mass spectrometry for qualitative analysis of unknown compounds. [0003] However, for some thermally unstable compounds or supramolecular compounds formed by weak forces, and metal complexes with weak coordinati...

AI Technical Summary

Problems solved by technology

However, this method still cannot be used for the qualitative analysis of some thermally unstable compounds that are very sensitive to environmental temperature changes, supramolecular compounds formed by weak forces, and metal complexes bonded by weak coordination bonds. high

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