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Application of pyrroloquinoline quinone and derivative and/or salt thereof as novel antiviral drug

A technology of pyrroloquinoline quinone and derivatives, which can be applied in the directions of antiviral agents, medical preparations containing active ingredients, antipyretics, etc., and can solve the problem that there is no specific treatment drug for diseases.

Pending Publication Date: 2021-05-28
NANJING SHUPENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is the problem that there is no specific treatment drug for the disease caused by the 2019-nCoV novel coronavirus

Method used

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  • Application of pyrroloquinoline quinone and derivative and/or salt thereof as novel antiviral drug
  • Application of pyrroloquinoline quinone and derivative and/or salt thereof as novel antiviral drug
  • Application of pyrroloquinoline quinone and derivative and/or salt thereof as novel antiviral drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0023] Experiment 1: PQQ inhibits the formation of MHV virus plaques in vitro

[0024] After the virus infects cells, due to the limitation of the solid medium, the released virus can only expand from the initially infected cells to the periphery. After several proliferation cycles, a limited area of ​​diseased cells is formed, which is the viral plaque. Theoretically, a plaque is formed by a virus particle that initially infected a cell. Therefore, this technique is often used to count virus particles and isolate virus clones, and it can also be used to detect the ability of virus infection and proliferation at the cellular level.

[0025] Materials and Methods

[0026] The MHV-A59 virus strain was purchased from Suzhou Xishan Biotechnology Co., Ltd., and the PFU / ml was 1.4X10 7 . Prepare MEM containing 1.5% carboxymethyl cellulose and 2% FBS in advance for the experiment, prepare it one day in advance and store it at 4°C overnight to ensure that the large air bubbles are ...

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PUM

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Abstract

The invention relates to a novel drug application of pyrroloquinoline quinine and derivatives and / or salts thereof. The novel drug application particularly relates to application of pyrroloquinoline quinine and derivatives and / or salts thereof in preparation of drugs for treating and / or preventing virus infection and complications such as pneumonia and inflammatory storm caused by virus infection. According to the invention, pyrroloquinoline quinone, derivatives and / or salts thereof are used for preparing medicines for treating and / or preventing virus infection and indications such as pneumonia, inflammatory storm and the like caused by the virus infection for the first time.

Description

technical field [0001] The present invention relates to the new drug use of pyrroloquinoline quinone, its derivatives and / or salts, and the new drug use specifically relates to the preparation of pyrroloquinoline quinone, its derivatives and / or salts for the treatment and / or prevention of viral infections and viral infections Complications caused by the application of drugs such as pneumonia, inflammatory storm. Background technique [0002] Coronaviruses are a large family of viruses known to cause colds as well as more serious illnesses such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). [0003] On January 12, 2020, the World Health Organization officially named the new coronavirus that has emerged since December 2019 as 2019-nCoV, which is a new strain of coronavirus that has never been found in humans before. [0004] Common signs after a person is infected with a coronavirus include respiratory symptoms, fever, cough, shortnes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4745A61P31/14A61P31/16A61P11/00A61P29/00
CPCA61K31/4745A61P31/14A61P31/16A61P11/00A61P29/00
Inventor 温传俊孙奋勇
Owner NANJING SHUPENG BIOTECH CO LTD
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