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Application of Tff1 in vascular diseases

A blood vessel and disease technology, applied in the application field of Tff1 in vascular diseases, can solve the problems of complex reasons and no literature reports on trefoil factor 1

Active Publication Date: 2021-06-08
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its causes are more complicated, and there is no accurate statement at present. In recent years, the incidence of infantile hemangiomas has become higher and higher, which has attracted widespread attention from many scholars and the society.
[0004] At present, there are reports in the prior art that trefoil factor 1 enhances the therapeutic effect of certain types of intestinal diseases, but there is no literature report on trefoil factor 1 in the treatment of blood vessel-related diseases

Method used

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  • Application of Tff1 in vascular diseases
  • Application of Tff1 in vascular diseases
  • Application of Tff1 in vascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. Establishment of the abdominal aortic aneurysm model induced by elastase

[0038] Male C57BL / 6 or DEREG mice aged 8-12 weeks were anesthetized by intraperitoneal injection of 1% pentobarbital sodium (50mg / kg), fixed on the mouse board with their backs facing down, and the model was established under a stereo microscope : Cut the skin and subcutaneous fascia with ophthalmic scissors from the center of the linea alba in order to make a longitudinal incision about 1.5 cm in length to expose the abdominal viscera, and use a small cotton swab to push the intestinal tube to both sides to fully expose the abdominal aorta and inferior cavity For the vein part, the abdominal aorta was carefully separated with microscopic forceps and suture needles, and the cotton cloth soaked with porcine trypsin was evenly covered on the wall of the abdominal aorta for 40 minutes, then the cotton cloth was discarded, and the abdominal cavity was washed with normal saline for 2 Finally, the i...

Embodiment 2

[0053] 1. Establishment of the abdominal aortic aneurysm model induced by elastase

[0054] 8-12 week-old male Foxp3cre / creTff1wt / wt or Foxp3cre / creTff1fl / fl mice were anesthetized by intraperitoneal injection of 1% sodium pentobarbital (50mg / kg), fixed on the mouse board with their backs down, and in vivo Under the microscope, start to build the model: cut the skin and subcutaneous fascia with ophthalmic scissors in sequence from the center of the abdominal linea alba to expose the abdominal viscera. For the abdominal aorta and inferior vena cava, the abdominal aorta was carefully separated with microscopic forceps and suture needles, and the cotton cloth soaked with porcine trypsin was evenly covered on the wall of the abdominal aorta for 40 minutes, and then the cotton cloth was discarded. The abdominal cavity was washed twice with normal saline, and the incision was sutured to close the abdominal cavity.

[0055] 2. Experimental grouping

[0056] (1) Control group: Foxp3...

Embodiment 3

[0068] 1. Establishment of the abdominal aortic aneurysm model induced by elastase

[0069] Male C57BL / 6 mice aged 8-12 weeks were anesthetized by intraperitoneal injection of 1% pentobarbital sodium (50 mg / kg), fixed on the mouse board with their backs facing down, and the model was established under a stereomicroscope: from In the middle of the linea alba, cut the skin and subcutaneous fascia in turn with ophthalmic scissors to make a longitudinal incision about 1.5 cm in length to expose the abdominal viscera, and use a small cotton swab to push the intestinal tube to both sides to fully expose the abdominal aorta and inferior vena cava , carefully separate the abdominal aorta with microscopic forceps and suture needles, and evenly cover the abdominal aortic wall with cotton cloth soaked with porcine trypsin for 40 minutes, then discard the cotton cloth and rinse the abdominal cavity twice with normal saline. Finally, the incision was sutured to close the abdominal cavity. ...

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Abstract

The invention belongs to the technical field of Tff1 research, and particularly discloses application of Tff1 in vascular diseases. The invention relates to application of Tff1 in preparation of drugs for preventing and treating vascular related diseases. The drugs for preventing and treating the vascular related diseases comprise an effective component Tff1. The invention discloses application of Tff1 as a vascular smooth muscle cell apoptosis inhibitor. The vascular smooth muscle cell apoptosis inhibitor comprises an effective component Tff1. A vascular elastic fiber degradation inhibitor comprises an effective component Tff1. According to the application of the Tff1 in vascular diseases, a trefoil factor 1 has a new application way; a novel drug for preventing and treating vascular diseases is provided; and the trefoil factor 1 plays a key role in inhibiting apoptosis of vascular smooth muscle cells and inhibiting degradation of vascular elastic fibers.

Description

technical field [0001] The invention belongs to the technical field of Tff1 research, in particular to the application of Tff1 in vascular diseases. Background technique [0002] Trefoil factor 1 (Tff1) is a small secreted protein belonging to the trefoil factor protein family that is mainly found in the gastrointestinal tract with highest levels in upper gastric mucosal cells. It is strongly expressed in breast cancer but at a lower level in normal breast tissue. It is regulated by estrogen in MCF-7 cells. Strong expression was found in normal gastric mucosa and regenerative tissue around gastrointestinal ulcer lesions, but lower expression was found in gastric cancer (at the protein level). [0003] Hemangioma is a relatively common vascular disease, mostly congenital, usually present at birth. Its causes are complex, and there is no accurate statement at present. In recent years, the incidence of infantile hemangioma has become higher and higher, which has attracted wi...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P9/14
CPCA61K38/1709A61P9/14
Inventor 程翔李静勇夏霓李丹刘鹤男文爽钱诗睿卢玉枝辜幕阳唐婷婷焦佼吕冰洁聂少芳
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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