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Dual-network microgel and preparation method thereof

A microgel and dual network technology, applied in the field of dual network microgel and its preparation, can solve the problems of complex preparation process of microgel, and achieve the effects of short preparation time and simple process

Inactive Publication Date: 2021-06-15
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a double-network microgel and its preparation method, aiming to solve the technical problem of complex microgel preparation process in the prior art to a certain extent

Method used

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  • Dual-network microgel and preparation method thereof

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preparation example Construction

[0027] like figure 1 As shown, the embodiment of the present invention provides a double network microgel and a preparation method thereof, wherein the preparation method includes the following steps:

[0028] S10. Prepare a mixed solution, the mixed solution includes: acrylamide monomer, sodium alginate, crosslinking agent, photoinitiator and solvent.

[0029] Specifically, the solvent is selected from deionized water and ultrapure water, that is, under stirring conditions, the acrylamide monomer, sodium alginate, crosslinking agent, and photoinitiator are uniformly dissolved in the solvent to obtain Mixture.

[0030] S20, dispersing the mixed solution into droplets, and adding the droplets into the calcium chloride solution to obtain a precursor solution.

[0031] Specifically, the mixed solution can be loaded into an atomizer, and the atomizer can be a sprayer, and the mixed solution passes through the nozzle of the sprayer to form dispersed small droplets, and the drople...

Embodiment 1

[0042] To prepare a mixed solution, weigh 1.7% sodium alginate, 20.4% acrylamide, N,N'-methylenebisacrylamide accounting for 0.12% of the acrylamide content, and 0.1% of the For ammonium sulfate, add the above raw materials into water, stir to dissolve completely, and obtain a mixed solution.

[0043] Atomize, put the mixed solution into the sprayer, adjust the pressure and spray width of the sprayer, spray the mixed solution into the calcium chloride solution of 0.5mol / L several times in a small amount, and get turbidity after spraying. liquid (precursor).

[0044] Put the turbid liquid into 30°C and 256nm ultraviolet light to cure for 1 hour, the product obtained after curing was washed several times, and centrifuged with a centrifuge to obtain calcium-sodium alginate / polyacrylamide microgel, The obtained calcium-sodium alginate / polyacrylamide microgel was freeze-dried and stored until use.

Embodiment 2

[0046] To prepare a mixed solution, weigh 1.7% of sodium alginate, 20.4% of acrylamide, N,N'-methylenebisacrylamide accounting for 0.12% of the acrylamide content, and 0.2% of the acrylamide content. For ammonium sulfate, add the above raw materials into water, stir to dissolve completely, and obtain a mixed solution.

[0047] Atomize, put the mixed solution into the sprayer, adjust the pressure and spray width of the sprayer, spray the mixed solution into the calcium chloride solution of 1.0mol / L several times in a small amount, and get turbidity after spraying. liquid (precursor).

[0048] The turbid solution was put into 35°C and 256nm ultraviolet light to cure for 1.5 hours, the product obtained after curing was washed several times, and centrifuged with a centrifuge to obtain calcium-sodium alginate / polyacrylamide microgel, The obtained calcium-sodium alginate / polyacrylamide microgel was freeze-dried and stored until use.

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Abstract

The invention provides a dual-network microgel and a preparation method thereof, and the method comprises the following steps: preparing a mixed solution which comprises an acrylamide monomer, sodium alginate, a cross-linking agent, a photoinitiator and a solvent; dispersing the mixed solution into liquid drops, and adding the liquid drops into a calcium chloride solution to obtain a precursor solution; and curing the precursor solution to obtain the dual-network microgel. The preparation method provided by the invention is simple in process and short in preparation time.

Description

technical field [0001] The invention relates to the technical field of gels, in particular to a double network microgel and a preparation method thereof. Background technique [0002] Hydrogel is a three-dimensional network structure polymer that is extremely hydrophilic, swellable in water and insoluble. The softness, swelling and biocompatibility of the gel material make it suitable for drug loading, wound There are good applications in dressings, artificial skin, etc. [0003] The double network is a composite gel material, which is composed of a flexible first layer of gel network and a rigid second layer of gel network. When stretching, the first layer of network is sacrificed to make the second layer of rigid gel The gel maintains high ductility and integrity, so it has the characteristics of high toughness, high strength, and high ductility, which greatly expands the application of the gel in the fields of biology and medical treatment. [0004] Due to the advantage...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L33/26C08L5/04C08K3/16C08F220/56C08F222/38
CPCC08J3/075C08F220/56C08J2333/26C08J2405/04C08K2003/162C08F222/385
Inventor 周学昌周小虎利纯
Owner SHENZHEN UNIV