Triazolopyridazine derivative as well as preparation method, pharmaceutical composition and application thereof

A technology of compounds and hydrates, applied in the field of triazolopyridazine derivatives, which can solve problems such as animal fear and anxiety
CN112979655APending Publication Date: 2021-06-18SHANGHAI SIMR BIOTECHNOLOGY CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI SIMR BIOTECHNOLOGY CO LTD
Publication Date
2021-06-18

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Abstract

The invention relates to triazolopyridazine derivatives as well as a preparation method, a pharmaceutical composition and application thereof. The invention provides a compound shown in a general formula (I), cis-trans isomers, enantiomers, diastereoisomers, racemes, solvates, hydrates or pharmaceutically acceptable salts or prodrugs of the compound, and a preparation method of the compound, the cis-trans isomers, the enantiomers, the diastereoisomers, the racemes, the solvates, the hydrates or the pharmaceutically acceptable salts or the prodrugs of the compound; preparation method thereof; pharmaceutical compositions containing the compounds, and the use of the compounds as alpha 5-GABAA receptor modulators, wherein R 1, R 2, and Z are as defined in the specification. pharmaceutical compositions containing the compounds and application of the compounds as alpha-5-GABAA receptor modulators, wherein R1, R2 and Z are as defined in the specification.
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Description

Technical field:

[0001] The present invention relates to α5-GABA A Triazolopyridazine derivatives with receptor modulating function, their preparation, pharmaceutical compositions containing them and their use as medicines. Background technique:

[0002] γ-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the mammalian central nervous system. There are two types of GABA receptors in nature, one is GABA A Receptors, which are members of the ligand-gated ion channel superfamily, the other is GABA B receptors, which are members of the G protein-coupled receptor superfamily. GABA in mammals A Receptor subunits are found to include α1-6, β1-4, γ1-3, δ, ε, θ and ρ1-2 subunits, among which the α subunit, β subunit and γ subunit pair form a complete functional GABA A receptor is essential, and the alpha subunit p-benzodiazepine and GABA A Receptor binding is critical.

[0003] GABA with α5 A receptor (α5-GABA A receptor) in the mammalian brain for GABA...

Claims

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