The invention discloses a preparation method of 2,2,2-trifluoroethylamine, which comprises the following steps of: (1) mixing liquid-phase 1,1,1-trifluoro-2-chloroethane dissolved into glycerin with ammonia, wherein the volume ratio of glycerin to 1,1,1-trifluoro-2-chloroethane is 1-3:1, the molar ratio of ammonia to 1,1,1-trifluoro-2-chloroethane is 8-15:1, and the concentration of ammonia ranges from 30wt% to 100wt%; reacting in a pipeline-type reactor for 20min to 30min at 150 DEG C and 200 DEG C under the pressure of 2MPa and 4MPA so as to obtain a mixed solution containing 2,2,2-trifluoroethylamine, wherein the flowing velocity of the reactant in the pipeline-type reactor is 2.0-4.0L / h; and (2) carrying out pressure reduction, flashing and deamination on the mixed solution of 2,2,2-trifluoroethylamine, and adding the liquid subjected to deamination into sodium carbonate for neutralizing , wherein the molar ratio of sodium carbonate to 1,1,1-trifluoro-2-chloroethane is 0.5-2:1; carrying out pressure reduction and rectification on the neutralized solution to obtain 2,2,2-trifluoroethylamine. The method has the advantages of short reaction time and high product yield.