33 results about "Trifluoroethylamine" patented technology

The invention relates to fatty trifluoroethyl ester compounds and a preparation method thereof. Wherein, the definition of fatty acid trifluoroethyl ester compound is the same as that in the claims. The preparation method includes the following steps: under low temperature conditions, add 2,2,2-trifluoroethylamine and tert-butyl nitrite into an organic solution in which fatty acids are dissolved, stir evenly, and continue to react at room temperature to obtain fatty acid three Fluoroethyl ester products. Wherein, the molar ratio of fatty acid to 2,2,2-trifluoroethylamine and tert-butyl nitrite is 1:(1-2.5):(1-2.5). The method of the present invention can obtain the target product without adding catalysts and other additives, has simple operation, mild reaction conditions, low cost, high yield, and is environmentally friendly, and can obtain trifluoroethyl esters of fats and drug molecule carboxylic acids Compounds are widely used.

The invention discloses a preparation method of trifluoroethylamine hydrochloride. First, trifluoroethylamine and hydrochloric acid are neutralized in an ethanol-water azeotropic or near-azeotropic system to obtain trifluoroethylamine hydrochloride The solution after the reaction, and the trifluoroethylamine hydrochloride obtained after desolvation and removal of water and ethanol by distillation under reduced pressure. The method provided by the invention is safe in technology, and the prepared product has high purity and low water content.

The present invention provides a process for producing highly pure fluoro-compounds by making use of N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process produces little or no chlorinated by-products. The present invention provides a process for producing a fluoro-compound, comprising fluorinating an alcohol derivative represented by the following general formula (I): R1R2R3COH (I), (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group; and R2 and R3 are each independently a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group, wherein at least two of R1, R2 and R3 may together form part of a ring structure, either with or without a heteroatom) with N,N-diethyl-2-chloro-1,1,2-trifluoroethylamine to form a fluoro-compound represented by the following general formula (2): R1R2R3CF (2), (wherein R1, R2 and R3 are as defined above), the process being characterized in that an alcohol derivative represented by the following general formula (3): R4OH (3), (wherein R4 represents a substituted or unsubstituted alkyl group or aryl group) is added to the reaction system.