Preparation method of alternating fluorine-containing polymer magnetic resonance imaging probe

Abstract

The invention discloses a preparation method of an alternating fluorine-containing polymer magnetic resonance imaging probe. According to the preparation method, an epoxy group in an ethylene oxide derivative is used as a modifiable point to connect a fluorine-containing group and a hydrophobic long chain, in the obtained polymer, a fluorine signal is provided by triethylamine, oleylamine increases the hydrophobicity of the polymer, and hydroxyl generated after ring opening of epoxy and amino increases the hydrophilicity of the polymer. The framework structure of the alternating polymer has a polyethylene glycol-like structure, the biocompatibility is good, the polarity is relatively strong, the chemical microenvironment of a side chain containing a fluorinated functional group is consistent, the half-peak width of 19F NMR is narrow, the position of a magnetic resonance peak is single, the dipole-dipole interaction between the fluorine-containing functional groups is weak, and the imaging signal intensity is improved. The alternating polymer is self-assembled to obtain the alternating fluorine-containing polymer magnetic resonance imaging probe, and the probe has a relatively good application prospect in the aspects of diagnosis and treatment of diseases.

Description

technical field [0001] The present invention relates to 19 F MRI technical field, in particular to a preparation method of an alternating fluorine-containing polymer fluorine magnetic resonance imaging probe. Background technique [0002] Early monitoring of diseases using in vivo imaging technology is of great significance for controlling the occurrence and development of diseases. Among them, magnetic resonance imaging technology is widely used in clinical disease detection due to its significant advantages such as high resolution, strong tissue penetration ability and no damage to organisms. However, due to the large water content of various tissues and organs in the human body, currently clinically applied 1 H MRI has problems such as large background interference and easy misdiagnosis. In contrast, the fluorine atoms contained in the human body are mostly in the solid form in the bones and teeth, so 19 There is almost no background interference of human endogenous f...

AI Technical Summary

Problems solved by technology

Traditional fluorine-containing polymers have a C-C structure with strong hydrophobicity, which makes the fluorine-containing groups prone to dipole-dipole interactions. Therefore, a fluorine atom with high magnetic resonance signal and modifiable sites (easy to function) has been developed. chemical modification), can be coated with hydrophobic molecules (to achieve drug and fluorescent molecule loading), simple preparation method (easy to scale production), and good biocompatibility polymer materials, which are useful for the construction of 19FMRI, Multifunctional probes such as detection analysis, diagnosis and treatment integration have important practical significance

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