Polymer containing lactide and preparation method thereof, medical material and surgical article

A technology of lactide and polymer, which is applied in the field of materials and chemical industry, can solve the problems of strength reduction and achieve good flexural strength retention rate and tensile strength retention rate, formability and thermal stability.

Pending Publication Date: 2021-06-18
SHENZHEN ANTMED CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, there is a limit to maintaining the heat-resistant strength while maintaining the same molecular weight; in addition, since lactide remains during the preparation of polylactic acid, the bending strength and tensile strength of the polymer containing lactide are between After prolonged use, the strength will be significantly reduced

Method used

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  • Polymer containing lactide and preparation method thereof, medical material and surgical article
  • Polymer containing lactide and preparation method thereof, medical material and surgical article
  • Polymer containing lactide and preparation method thereof, medical material and surgical article

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preparation example Construction

[0040]The present invention further proposes a method for preparing a lactide-containing polymer as described above, comprising at least one of the following three steps:

[0041] (1) During the polymerization of polylactic acid prepared by lactide polymerization, when the polymerization reaction is carried out to 0.5-72h, adjust the pressure condition of the polymerization reaction to negative pressure and maintain it for 0.5-72h;

[0042] (2) After the polymerization reaction of preparing polylactic acid by lactide polymerization is completed, the polymerization product is vacuum-dried for 10-20 hours at 120° C. under a pressure of 1-10 mmHg;

[0043] (3) Washing and drying the polymerization product of polylactic acid prepared by polymerization of lactide with a solvent.

[0044] Decompression during the lactide polymerization process is conducive to the positive polymerization reaction, so that each lactide is connected to each other by ring opening. The preferred conditio...

Embodiment 1

[0057] Under the condition that the molding temperature is 200-210°C, the polylactic acid is directly molded through the extruder without granulation, so that the diameter is Columns in the form of cylinders. The columnar material was subjected to vacuum thermal drying (under a reduced pressure of 1 mmHg, at 120° C. for 10 h) to obtain a columnar material with reduced lactide content. In addition, each pillar was stretched at a stretch ratio of 2.5 at a die temperature of 120-140°C using a hydrostatic extruder to prepare rods, each rod was cut and drawn to prepare a top diameter of A screw sample with a total length of 30 mm, the weight average molecular weight of the lactide-containing polymer in the screw sample is 189000, and the lactide content is 1319 ppm.

Embodiment 2

[0059] Under the condition that the molding temperature is 200~210℃, polylactic acid is directly molded through the extruder without granulation, so as to obtain a polylactic acid with a diameter of Columns in the form of cylinders. The column was subjected to vacuum thermal drying (under a reduced pressure of 10 mmHg, at 120° C. for 20 h) to obtain a column with reduced lactide content. In addition, each pillar was stretched at a stretch ratio of 2.5 at a die temperature of 120 to 140°C using a hydrostatic extruder to prepare rods, each rod was cut and drawn to prepare a top diameter of A screw sample with a total length of 30 mm, the weight average molecular weight of the lactide-containing polymer in the screw sample is 176,000, and the lactide content is 1442 ppm.

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Abstract

The invention discloses a polymer containing lactide and a preparation method thereof, a medical material and a surgical article, and relates to the technical field of materials and chemical engineering. The polymer containing lactide comprises polylactic acid and lactide, the weight-average molecular weight of the polymer containing lactide is less than 1500000, and the content of lactide in the polymer containing lactide is not more than 4000 ppm. According to the present invention, by reducing the content of the low-molecular polymer, especially the lactide, contained in the polymer, such that the sublimation phenomenon of the lactide does not occur during the processing and using process of the polymer, and when the lactide content is less than 4000 ppm, the formability and the thermal stability significantly become good, such that the requirement on the weight-average molecular weight of the polymer is not high under the same strength, and after the polymer is used for a long time, relatively good bending strength retention rate and tensile strength retention rate can still be kept.

Description

technical field [0001] The invention relates to the technical fields of materials and chemicals, in particular to a lactide-containing polymer and a preparation method thereof, medical materials and surgical supplies. Background technique [0002] With the continuous improvement of medical level, more and more surgical instruments are used. Polylactic acid is highly safe to the human body and can be absorbed by tissues. In addition to its excellent physical and mechanical properties, it can also be used in the field of biomedicine. As a medical material, The disadvantage of polylactic acid is that its strength remains low, and its strength in the body will drop significantly in a short period of time. [0003] At present, the molecular weight of polylactic acid has been increased to increase its strength; however, if the molecular weight is too large, the thermal processing performance of polylactic acid will be greatly reduced. For example, when polylactic acid is heated a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/08C08G63/78A61L27/18A61L31/06A61L17/12A61L27/50A61L31/14
CPCC08G63/08C08G63/78A61L27/18A61L31/06A61L17/12A61L27/50A61L31/14A61L2430/02A61L2430/10
Inventor 张平吴姗姗王五星
Owner SHENZHEN ANTMED CO LTD
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