Preparation method of double-loading pesticide nano microcapsule suspending agent

A technology of nano-microcapsules and suspending agents, applied in botany equipment and methods, insecticides, biocides, etc., can solve the problems of poor solubility and poor stability, and achieve the effects of simple method, low cost, environmental protection, and labor saving

Active Publication Date: 2021-06-22
INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a method for preparing a double-loaded pesticide nano-microcapsule suspension that can realize the compounding of pesticides with different solubility in view of the defects of poor solubility and poor stability of the existing pesticide single agent

Method used

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  • Preparation method of double-loading pesticide nano microcapsule suspending agent
  • Preparation method of double-loading pesticide nano microcapsule suspending agent
  • Preparation method of double-loading pesticide nano microcapsule suspending agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Preparation of double-loaded pesticide nano-microcapsule suspension with an average particle size of 500nm-900nm

[0034] Specific steps are as follows:

[0035] (1) Preparation of solid phase

[0036] According to the effective drug content of commercially available water-dispersible granule pesticides, weigh 40 mg of chlorantraniliprole and dissolve in 5 mL of deionized water, then add 0.05 g of polyvinyl alcohol and 0.5 g of bovine serum albumin, and stir evenly with a magnetic stirrer. Prepare a suspension of chlorantraniliprole, which is the solid phase S;

[0037] (2) Preparation of oil phase

[0038] Weigh 40 mg of lambda-cyhalothrin and dissolve it in 20 mL of dichloromethane, then add 0.6 g of polylactic acid, fully dissolve under the action of a magnetic stirrer, and obtain oil phase O;

[0039] (3) Preparation of external water phase

[0040] Weigh 0.48g of polyvinyl alcohol and dissolve it in 120mL of ionized water as the external water phase ...

Embodiment 2

[0044] Example 2: Preparation of double-loaded pesticide nano-microcapsule suspension with an average particle size of 400nm-500nm

[0045] Specific steps are as follows:

[0046] (1) Preparation of solid phase

[0047]According to the effective drug content of commercially available water-dispersible granule pesticides, weigh 40 mg of chlorantraniliprole and dissolve in 5 mL of deionized water, then add 0.05 g of polyvinyl alcohol and 0.5 g of bovine serum albumin, and stir evenly with a magnetic stirrer , prepared into a suspension of chlorantraniliprole, which is the solid phase S;

[0048] (2) Preparation of oil phase

[0049] Weigh 40 mg of lambda-cyhalothrin and dissolve it in 20 mL of dichloromethane, then add 0.6 g of polylactic acid, and fully dissolve it under the action of a magnetic stirrer to obtain oil phase O;

[0050] (3) Preparation of external water phase

[0051] Weigh 0.24% polyvinyl alcohol and dissolve it in 120mL deionized water as the external water...

Embodiment 3

[0055] Example 3: Preparation of double drug-loaded microcapsule suspension with an average particle diameter of about 300nm

[0056] Specific steps are as follows:

[0057] (1) Preparation of solid phase

[0058] According to the effective drug content of commercially available water-dispersible granule pesticides, weigh 40 mg of chlorantraniliprole and dissolve in 5 mL of deionized water, then add 0.05 g of polyvinyl alcohol and 0.5 g of bovine serum albumin, and stir evenly with a magnetic stirrer , prepared into a suspension of chlorantraniliprole, which is the solid phase S;

[0059] (2) Preparation of oil phase

[0060] Weigh 40 mg of lambda-cyhalothrin and dissolve it in 20 mL of dichloromethane, then add 0.6 g of polylactic acid, and fully dissolve it under the action of a magnetic stirrer to obtain oil phase O;

[0061] (3) Preparation of external water phase

[0062] Weigh 0.24% polyvinyl alcohol and dissolve it in 120mL deionized water as the external water phas...

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Abstract

The invention discloses a preparation method of a double-loading pesticide nano microcapsule suspending agent. The preparation method comprises the following steps: firstly, diluting chlorantraniliprole raw medicine with deionized water, then adding polyvinyl alcohol and bovine serum albumin, and dissolving as a solid phase (S); diluting lambda-cyhalothrin with dichloromethane, adding polylactic acid, and dissolving to obtain an oil phase (O); diluting polyvinyl alcohol with deionized water to serve as an outer water phase (W); slowly pouring the solid phase S into an oil phase under high-speed shearing, shearing for one minute to form a water-in-oil primary emulsion, and carrying out ultrasonic emulsification on the obtained primary emulsion at certain power for three minutes to obtain a double-loading multiple emulsion system; and centrifuging for 10 minutes at a high speed of 10000 rpm for three times, discarding the supernate after each centrifugation, supplementing the same amount of deionized water for complete dispersion, and finally volatilizing at room temperature for 24 hours to obtain the double-loading pesticide nano microcapsule suspending agent. According to the method disclosed by the invention, the compounding power of different soluble pesticides is improved, and slow controlled release of the two pesticides is realized at the same time.

Description

【Technical field】 [0001] The invention relates to a preparation method of a double-loaded pesticide nano-microcapsule suspension, in particular to coating two pesticides with different solubility into microcapsules layer by layer under certain external force conditions, and belongs to the field of pesticide formulation preparation. 【Background technique】 [0002] my country is one of the largest pesticide consumption countries in the world, but 90% of pesticides are lost in the environment every year or cannot reach the target area required for effective pest control, so the application often exceeds the recommended dosage, causing a lot of waste and pollution. Traditional pesticide formulations such as emulsifiable concentrates, suspension concentrates, and wettable powders have low effective utilization rates, low biological activity, and are greatly affected by climatic conditions, resulting in serious pesticide residues and environmental pollution. [0003] The combinati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/56A01N53/08A01N25/18A01N25/28A01N25/04A01P7/04
CPCA01N43/56A01N53/00A01N25/18A01N25/28A01N25/04
Inventor 曾章华冯博媛智亨崔海信
Owner INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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