The invention relates to the technical field of preparation of medical wine, and in particular relates to wine for treating rheumatism and traumatic injuries from fall, fractures, contusions and strains and a preparation method of the wine. The wine for treating rheumatism and traumatic injuries from fall, fractures, contusions and strains is prepared from the following medicinal materials in parts by weight: 1-2 parts of centipedes, 2-4 parts of ramulus cinnamomi, 1-2 parts of fructus psoraleae, 4-6 parts of fructus aurantii, 3-5 parts of silkworm excrement, 7-10 parts of monascus in oryzae fructus, 3-5 parts of flos carthami, 2-4 parts of rhizoma chuanxiong, 1-3 parts of semen armeniacae amarae, 2-4 parts of olibanum, 1-3 parts of radix angelica sinensis, 15-22 parts of caulis erycibes,1-3 parts of rhizoma alismatis, 5-10 parts of herba ephedra, 3-5 parts of radix angelicae pubescentis, 1-2 parts of rhizoma atractylodis, 2-4 parts of moutan bark, 1-3 parts of radix aucklandiae, 2-5parts of musk, 2-4 parts of brown sugar, and 35-45 parts of baijiu. According to the technical scheme, the elaborately prepared traditional Chinese medicinal materials and the advanced and scientificpreparation method are adopted, so that the prepared wine for treating rheumatism and traumatic injuries from fall, fractures, contusions and strains has the advantage that the efficacies of the raw medicinal materials can be exerted to the maximum, and the wine also has the efficacies of dispelling wind and eliminating dampness, as well as eliminating blood stasis and relieving pain, and has special curative effects for the diseases including hand and foot numbness, waist and leg aching pain, traumatic injuries from fall, fractures, contusions and strains, and the like.