A self-healing polyanion-chitosan quaternary ammonium hydrogel and its application

A chitosan quaternary ammonium salt and polyanion technology, applied in the field of polymer hydrogels, can solve the problems that the shape cannot be changed at will, unfavorable transplantation, etc., and achieve the effects of low price, abundant material sources, and easy shape.

Active Publication Date: 2019-01-25
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, calcium alginate is commonly used as the gel material, but once the hydrogel is prepared, its shape cannot be changed at will, which is not conducive to subsequent applications such as transplantation.

Method used

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  • A self-healing polyanion-chitosan quaternary ammonium hydrogel and its application
  • A self-healing polyanion-chitosan quaternary ammonium hydrogel and its application
  • A self-healing polyanion-chitosan quaternary ammonium hydrogel and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Prepare sodium alginate and chitosan quaternary ammonium salt solutions, the concentrations are respectively 20g / L and 40g / L, and the solvent is deionized water. Sodium alginate has a molecular weight of 430kDa and a G fragment content of 35%. The degree of substitution of chitosan quaternary ammonium salt is 85%, and the molecular weight is 78kDa.

[0031] (2) Add the chitosan quaternary ammonium salt solution into an equal volume of sodium alginate solution under shaking conditions, shake and mix well.

[0032] (3) Static precipitation for 2 hours to collect the product. The formed gels were stained with red basic fuchsin and blue methylene blue respectively, and the two cake-like gels with different colors were evenly divided into 4 parts, and rearranged according to the principle of staggered colors, so that the cut two pieces Gel close up. Thereafter, the gel state was observed at different times. The result is as figure 1 As shown, the boundaries of the t...

Embodiment 2

[0034](1) Prepare carboxymethylcellulose sodium and chitosan quaternary ammonium salt solutions, the mass fraction is 20g / L, and the solvent is deionized water. The molecular weight of sodium carboxymethyl cellulose is 500kDa. The degree of substitution of chitosan quaternary ammonium salt is 85%, and the molecular weight is 78kDa.

[0035] (2) Add the chitosan quaternary ammonium salt solution into an equal volume of sodium alginate solution under shaking conditions, shake and mix well.

[0036] (3) Static precipitation collected the product for 2 hours, and carried out rheological analysis, such as figure 2 It is shown that by increasing the strain, the structure of the gel is destroyed, and the structure of the gel recovers rapidly after the stress is reduced, and the storage modulus recovers to more than 65% of its original value.

Embodiment 3

[0038] (1) Prepare sodium alginate and chitosan quaternary ammonium salt solutions, the concentrations are respectively 20g / L and 40g / L, and the solvent is deionized water. Sodium alginate has a molecular weight of 430kDa and a G fragment content of 35%. The degree of substitution of chitosan quaternary ammonium salt is 85%, and the molecular weight is 78kDa.

[0039] (2) Add the chitosan quaternary ammonium salt solution into an equal volume of sodium alginate solution under shaking conditions, shake and mix well.

[0040] (3) Static precipitation for 2 hours to collect the product. The formed gel was mixed with water-soluble methylene blue and oil-soluble rhodamine B respectively, and the final drug concentration was 0.1 g / L.

[0041] (4) Collect 1 mL of the gel and place it in 10 mL of phosphate buffer (pH=7.4). At 25°C, the two drugs both exhibit fast and then slow release behavior. The drug release reaches 50% in 24 hours, and the drug is released after 7 days. The con...

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Abstract

The invention discloses a self-healing polyanion-chitosan quaternary ammonium hydrogel and its application in the field of medicine and biology. The preparation process of the hydrogel includes: preparing polyanion solution and chitosan quaternary ammonium salt solution respectively, after the two solutions are fully mixed, the two spontaneously aggregate under electrostatic interaction, a gelation reaction occurs, and the solid is collected The precipitate obtains polyanion-chitosan quaternary ammonium hydrogel. The raw materials for preparing the hydrogel are rich in sources and low in price. The hydrogel has good biocompatibility, has self-healing properties, and avoids factors such as organic solvents and acid-base environments during the formation process. It lays the foundation for the application of drugs and proteins, and has the advantages of injectability and high adhesion. When applied to tissue regeneration scaffolds, it has the advantages of mild preparation conditions, controllable shape and high water content, and is a good extracellular matrix material.

Description

technical field [0001] The invention relates to a polymer hydrogel, in particular to a self-healing polyanion-chitosan quaternary ammonium salt composite hydrogel and application thereof. Background technique [0002] Polymer hydrogel is a three-dimensional network structure polymer that can absorb and retain a large amount of water. The chemical cross-linking or physical cross-linking structure inside it can only swell but not dissolve. Polymer hydrogel has excellent viscoelasticity, high water content and water retention rate, and good biocompatibility. It can be applied in the fields of agriculture, food engineering and biomedicine. However, due to the high water content of polymer hydrogel, it will be destroyed due to low strength when subjected to tensile or compressive stress, which is difficult to meet the needs of practical applications. [0003] Hydrogel materials with self-healing function are expected to solve the above problems and are suitable for long-term us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/02C08L5/08C08L5/04C08L1/28
Inventor 马小军任英于炜婷谢红国郑会珍高梦
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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