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Poly-docanol foam hardener stabilizer and application thereof

A technology of foam hardening agent and polidocanol, which is applied in the direction of aerosol delivery, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of insufficient stability of polidocanol foam, foam Poor stability of the hardener and prolonging the half-life of the foam, etc., to overcome the lack of stability, enhance the stability, and prolong the half-life of the foam

Active Publication Date: 2021-06-25
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problem of poor stability of the foam hardening agent in the prior art, the present disclosure adds a small amount of gold nanoclusters and sodium hyaluronate on the basis of the Tessari method. Solved the problem of insufficient stability of polidocanol foam

Method used

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  • Poly-docanol foam hardener stabilizer and application thereof
  • Poly-docanol foam hardener stabilizer and application thereof
  • Poly-docanol foam hardener stabilizer and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The present embodiment provides a kind of method preparing polydocanol foam hardening agent, comprises the steps:

[0048] (1) Add 1% polidocanol (POL) to physiological saline to prepare a solution.

[0049] (2) Connect two disposable syringes (5mL) through a medical tee, and mix the 2.18mL solution obtained in (1) and air at a ratio of 2:2 between the two syringes to obtain foam .

[0050] (3) Separate the foam obtained in step 2 from the three-way stopcock, place it vertically and start counting, observe the liquid volume formed at the bottom, and stop counting when the liquid volume formed at the bottom is half of the original liquid volume (1.09mL). is the half-life of the foam.

Embodiment 2

[0052] The present embodiment provides a kind of method that strengthens the stability of polydocanol foam hardening agent, comprises the steps:

[0053] (1) Add gold nanoclusters (AuNCs) and 1% polidocanol (POL) to physiological saline to prepare a solution, and the concentration of gold nanoclusters (AuNCs) is 4%.

[0054] (2) Connect two disposable syringes (5mL) through a medical tee, and mix the 2.18mL solution obtained in (1) and air at a ratio of 2:2 between the two syringes to obtain foam .

[0055] (3) Separate the foam obtained in step 2 from the three-way stopcock, place it vertically and start counting, observe the liquid volume formed at the bottom, and stop counting when the liquid volume formed at the bottom is half of the original liquid volume (1.09mL). is the half-life of the foam.

Embodiment 3

[0057] The present embodiment provides a kind of method that strengthens the stability of polydocanol foam hardening agent, comprises the steps:

[0058] (1) Sodium hyaluronate (HA) and 1% polidocanol (POL) were added to physiological saline to prepare a solution, and the concentration of sodium hyaluronate (HA) was 5%.

[0059] (2) Connect two disposable syringes (5mL) through a medical tee, and mix the 2.18mL solution obtained in (1) and air at a ratio of 2:2 between the two syringes to obtain foam .

[0060] (3) Separate the foam obtained in step 2 from the three-way stopcock, place it vertically and start counting, observe the liquid volume formed at the bottom, and stop counting when the liquid volume formed at the bottom is half of the original liquid volume (1.09mL). is the half-life of the foam.

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Abstract

The invention relates to the technical field of medical foam hardeners, and particularly provides a poly-docanol foam hardener stabilizer and application thereof. A hardener is prepared from gold nanoclusters and sodium hyaluronate. A method comprises the following steps: (1) adding gold nanoclusters, sodium hyaluronate and polydocanol into normal saline to prepare a solution; (2) connecting two disposable syringes through a medical tee joint, and quickly injecting and mixing the mixed solution obtained in the step (1) and air back and forth between the two syringes so as to obtain foam; and (3) separating the foam obtained in the step (2) from a three-way plug valve. The problem that in the prior art, a foam hardening agent is poor in stability is solved.

Description

technical field [0001] The disclosure relates to the technical field of medical foam hardening agents, and specifically provides a polydocanol foam hardening agent stabilizer and its application. Background technique [0002] The statements herein merely provide background information related to the present disclosure and may not necessarily constitute prior art. [0003] Polydocanol foam hardener is currently the most widely used foam hardener in the world. It entered the Chinese market in January 2015. Its active ingredient is polydocanol, which is an alkyl polyethylene glycol ether of lauryl alcohol. , whose average empirical formula is C 30 h 62 o 10 , Chemically defined as a polyoxyethylene ether composed of an alkyl chain (C12-C14) with an average of 12 to 14 carbon atoms and an ethylene oxide chain of 9 ethylene oxide units. It is a viscous liquid at room temperature, with a melting point of 15-21°C. It is miscible with water. The pH value of 1% aqueous solution i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/765A61K47/02A61K47/36A61P9/14A61P7/04
CPCA61K9/122A61K31/765A61K47/02A61K47/36A61P7/04A61P9/14
Inventor 蒋妍彦刘超李晓凤袁俊晓杨帆孔晓冰
Owner SHANDONG UNIV