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A kind of polydocanol foam hardening agent stabilizer and application thereof

A technology of foam hardening agent and polidocanol, which is applied in the direction of aerosol delivery, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of poor stability of foam hardening agents and polidocanol Insufficient foam stability, prolonging the half-life of foam and other problems, to achieve the effect of enhancing stability, overcoming insufficient stability, and prolonging the half-life of foam

Active Publication Date: 2021-12-07
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problem of poor stability of the foam hardening agent in the prior art, the present disclosure adds a small amount of gold nanoclusters and sodium hyaluronate on the basis of the Tessari method. Solved the problem of insufficient stability of polidocanol foam

Method used

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  • A kind of polydocanol foam hardening agent stabilizer and application thereof
  • A kind of polydocanol foam hardening agent stabilizer and application thereof
  • A kind of polydocanol foam hardening agent stabilizer and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The present embodiment provides a kind of method preparing polydocanol foam hardening agent, comprises the steps:

[0048] (1) Add 1% polidocanol (POL) to physiological saline to prepare a solution.

[0049] (2) Connect two disposable syringes (5mL) through a medical tee, and mix the 2.18mL solution obtained in (1) and air at a ratio of 2:2 between the two syringes to obtain foam .

[0050] (3) Separate the foam obtained in step 2 from the three-way stopcock, place it vertically and start counting, observe the liquid volume formed at the bottom, and stop counting when the liquid volume formed at the bottom is half of the original liquid volume (1.09mL). is the half-life of the foam.

Embodiment 2

[0052] The present embodiment provides a kind of method that strengthens the stability of polydocanol foam hardening agent, comprises the steps:

[0053] (1) Add gold nanoclusters (AuNCs) and 1% polidocanol (POL) to physiological saline to prepare a solution, and the concentration of gold nanoclusters (AuNCs) is 4%.

[0054] (2) Connect two disposable syringes (5mL) through a medical tee, and mix the 2.18mL solution obtained in (1) and air at a ratio of 2:2 between the two syringes to obtain foam .

[0055] (3) Separate the foam obtained in step 2 from the three-way stopcock, place it vertically and start counting, observe the liquid volume formed at the bottom, and stop counting when the liquid volume formed at the bottom is half of the original liquid volume (1.09mL). is the half-life of the foam.

Embodiment 3

[0057] The present embodiment provides a kind of method that strengthens the stability of polydocanol foam hardening agent, comprises the steps:

[0058] (1) Sodium hyaluronate (HA) and 1% polidocanol (POL) were added to physiological saline to prepare a solution, and the concentration of sodium hyaluronate (HA) was 5%.

[0059] (2) Connect two disposable syringes (5mL) through a medical tee, and mix the 2.18mL solution obtained in (1) and air at a ratio of 2:2 between the two syringes to obtain foam .

[0060] (3) Separate the foam obtained in step 2 from the three-way stopcock, place it vertically and start counting, observe the liquid volume formed at the bottom, and stop counting when the liquid volume formed at the bottom is half of the original liquid volume (1.09mL). is the half-life of the foam.

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Abstract

The disclosure relates to the technical field of medical foam hardening agents, and specifically provides a polydocanol foam hardening agent stabilizer and its application. The hardener includes gold nanoclusters and sodium hyaluronate. The method comprises the following steps: (1) adding gold nanoclusters, sodium hyaluronate and polidocanol to physiological saline to form a solution; (2) connecting two disposable syringes through a medical tee, Mix the mixed solution obtained in step (1) and air back and forth quickly between two syringes to obtain foam; (3) separate the foam obtained in step (2) from the three-way stopcock to obtain the obtained product. The problem of poor stability of the foam hardening agent in the prior art is solved.

Description

technical field [0001] The disclosure relates to the technical field of medical foam hardening agents, and specifically provides a polydocanol foam hardening agent stabilizer and its application. Background technique [0002] The statements herein merely provide background information related to the present disclosure and may not necessarily constitute prior art. [0003] Polydocanol foam hardener is currently the most widely used foam hardener in the world. It entered the Chinese market in January 2015. Its active ingredient is polydocanol, which is an alkyl polyethylene glycol ether of lauryl alcohol. , whose average empirical formula is C 30 h 62 o 10 , Chemically defined as a polyoxyethylene ether composed of an alkyl chain (C12-C14) with an average of 12 to 14 carbon atoms and an ethylene oxide chain of 9 ethylene oxide units. It is a viscous liquid at room temperature, with a melting point of 15-21°C. It is miscible with water. The pH value of 1% aqueous solution i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K31/765A61K47/02A61K47/36A61P9/14A61P7/04
CPCA61K9/122A61K31/765A61K47/02A61K47/36A61P7/04A61P9/14
Inventor 蒋妍彦刘超李晓凤袁俊晓杨帆孔晓冰
Owner SHANDONG UNIV