Preparation method of lycopene particles based on subcritical extraction and supercritical granulation combined process

A technology of lycopene and combined process, applied in the direction of extraction and purification/separation, chemical instruments and methods, hydrocarbons, etc., can solve the problems of inability to be absorbed by the human body, poor solubility, etc., and achieve the goal of improving bioavailability and efficient extraction Effect

Active Publication Date: 2021-06-29
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, even if the human body takes pure lycopene, it cannot be absorbed by the human body due to its poor solubility. This is also the real bottleneck problem when lycopene is actually used.

Method used

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  • Preparation method of lycopene particles based on subcritical extraction and supercritical granulation combined process
  • Preparation method of lycopene particles based on subcritical extraction and supercritical granulation combined process
  • Preparation method of lycopene particles based on subcritical extraction and supercritical granulation combined process

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Accurately weigh 66g of the pretreated tomato, put it into the extraction tank, add 1600mL of pure water, seal the tank, turn on the agitator, adjust to 120r / min, turn on the heater, heat to 110°C and pressurize, when When the pressure gauge reaches 1 MPa, stop pressurizing, and continue heating and extracting at 110°C for 30 minutes. After the extraction, turn on the circulation pump, cool the steam released from the extraction tank with cooling water, and then further cool down after passing through the low-temperature cooling tank, and finally the extract enters the receiving tank, and the extraction rate is 342.4 μg / g measured by ultraviolet spectrophotometry.

Embodiment 2

[0032]Accurately weigh 66g of the pretreated tomato, put it into the extraction tank, add 1600mL of pure water, seal the tank, turn on the agitator, adjust to 120r / min, turn on the heater, heat to 120°C and pressurize, when When the pressure gauge reaches 1 MPa, stop pressurizing, and continue heating and extracting at 120°C for 30 minutes. After the extraction is finished, turn on the circulation pump, cool the steam released from the extraction tank with cooling water, and then further cool down after passing through the low-temperature cooling tank, and finally the extract enters the receiving tank, and the extraction rate is 848.0 μg / g measured by ultraviolet spectrophotometry.

Embodiment 3

[0034] Accurately weigh 66g of the pretreated tomato, put it into the extraction tank, add 1600mL of pure water, seal the tank, turn on the agitator, adjust to 120r / min, turn on the heater, heat to 130°C and pressurize, when After the pressure gauge reached 1 MPa, the pressurization was stopped, and the extraction was continued at 130°C for 30 minutes. After the extraction, turn on the circulation pump, cool the steam released from the extraction tank with cooling water, and then cool it further after passing through a low-temperature cooling tank. Finally, the extract enters the receiving tank. The extraction rate is 689.6 μg / g measured by ultraviolet spectrophotometry.

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Abstract

The invention discloses a method comprising the steps: pretreating fresh tomatoes, green-extracting lycopene by using subcritical water, and collecting an extracting solution; and removing water from the extracting solution, adding no auxiliary material, and granulating by a supercritical carbon dioxide fluid technology to obtain the high-solubility lycopene particles. According to the method, the extraction rate of the lycopene is increased to 342.4-1060.8 [mu]g/g from 99.45 [mu]g/g and is increased by 10.7 times at most, the solubility of the prepared lycopene particles is increased to 0.005 [mu]g/mL from 0.002 [mu]g/mL and is increased by 2.5 times, and the two major problems that the extraction rate of the lycopene is low and the utilization rate of the extracted lycopene is low when the lycopene is used are effectively solved.

Description

technical field [0001] The invention relates to a preparation method of lycopene microparticles, in particular to a preparation method of lycopene microparticles based on a combined process of subcritical extraction and supercritical granulation. Background technique [0002] Lycopene (Lycopene) exists widely in nature and exists in various fruits and vegetables, including tomato, watermelon, pumpkin, papaya, etc. It is one of the main pigments in ripe tomato. Lycopene has a very strong antioxidant capacity, its antioxidant capacity far exceeds other substances in nature, and it is also one of the most antioxidant substances in nature (The American Journal of Clinical Nutrition, 2012, 96(5): 1173-1178 ). Lycopene has a variety of biological activities and functions, which can enhance the body's oxidative stress ability, remove free radicals in the body, protect the skin, and enhance immunity. Therefore, lycopene is often used in cosmetics, health products, food and beverage...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C11/21C07C7/00C07C7/10C07C7/14
CPCC07C7/005C07C7/10C07C7/14C07C11/21Y02P20/54
Inventor 黄德春赵坤锋邹俊辉钱红亮李博陈维
Owner CHINA PHARM UNIV
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