Construction method and equipment of brain template and atlas of spontaneously hypertensive rats
A construction method and high blood pressure technology, applied in the field of medical image processing, can solve problems such as positioning deviation of anatomical positions, affecting image registration accuracy, and affecting research conclusions, and achieve the effects of facilitating analysis, realizing brain region extraction, and realizing accurate positioning
Active Publication Date: 2022-01-11
THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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Problems solved by technology
Forcibly adopting the standard template of healthy rat brains to perform spatial transformation on individual SHR brain images will affect the registration accuracy of the images and cause deviations in anatomical position positioning, resulting in errors that will affect the research conclusions
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[0240] 1. Experimental animals
[0241] Eight SHRs were scanned by T2WI, DTI and fMRI at three time points (10, 24, 52 weeks). Rats are kept at an ambient temperature of 22-24° C., a relative humidity of 50-60%, and a 12-hour cycle of day and night. All rats were fed a standard diet and had free access to water. Blood pressure measurements were performed on all rats at 20 weeks of age. Systolic blood pressure, diastolic blood pressure, mean arterial pressure were measured 3 times to get the average value. Rat body weights were measured weekly from 8 to 52 weeks.
[0242] 2. Multimodal MRI scan
[0243] Scanning was performed with a 7.0T Bruker small animal magnetic resonance scanner. Rats were anesthetized with 3% isoflurane, and 0.015 mg / kg of dexmedetomidine was intramuscularly injected into the back of the right thigh. The rats were lying on the scanning bed, and the anesthesia was maintained by mixing isoflurane and medical oxygen. T2WI and DTI scanning isoflurane 0...
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The invention discloses a method for constructing brain templates and atlases of spontaneously hypertensive rats, and related equipment, wherein the method for constructing brain templates for spontaneously hypertensive rats is constructed using magnetic resonance brain images of spontaneously hypertensive rats Brain template, the obtained brain template can better realize the accurate registration of the magnetic resonance brain images of spontaneously hypertensive rats, and facilitate the analysis of brain image data of spontaneously hypertensive rats; according to the present invention, the spontaneous high Construction method of blood pressure rat atlas The obtained atlas can realize accurate positioning of brain tissue and extraction of brain regions in spontaneously hypertensive rats, and provide a basis for the construction of a structural or functional network map of the whole brain.
Description
technical field [0001] The present invention relates to the technical field of medical image processing, and more specifically, to a method for constructing a brain template of spontaneously hypertensive rats, a method for constructing an atlas of spontaneously hypertensive rats, electronic equipment, and a computer-readable storage medium. Background technique [0002] With the development of population aging, body damage and various complications caused by high blood pressure seriously restrict the health level and quality of life of the elderly population, consuming a large amount of medical and social resources. The number of hypertensive patients in the world has increased significantly, and the prevention and management of hypertension need to be highly valued. Recognizing and understanding the impact of hypertension on the brain aging process can provide an important basis for "early prevention, early diagnosis, early intervention, and early treatment" of hypertension...
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IPC IPC(8): G06T7/33G06T7/00G06T3/00
CPCG06T7/337G06T7/0014G06T2207/30016G06T2207/10088G06T2207/20076G06T2207/20216G06T3/147
Inventor 耿左军杨迎迎张权任嘉良朱青峰王立新张勇智
Owner THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV