Dimethyl fumarate eye drops, preparation method thereof and application of dimethyl fumarate eye drops as medicine for treating fungal keratitis

Abstract

The invention discloses dimethyl fumarate eye drops, a preparation method thereof and application of the dimethyl fumarate eye drops as a medicine for treating fungal keratitis, and belongs to the technical field of pharmacy. According to the dimethyl fumarate eye drops disclosed by the invention, dimethyl fumarate is used as an effective component; the concentration of dimethyl fumarate is less than or equal to 5ug / mL; and the dimethyl fumarate eye drops can effectively kill pathogenic bacteria of fungal keratitis, does not irritate eyes, and does not generate adverse effects. The dimethyl fumarate eye drops disclosed by the invention can be applied as the medicine for treating fungal keratitis; the antifungal function is achieved by inhibiting the growth of fungi and weakening the adhesion ability of fungi to cells; the keratitis reaction is relieved by reducing the inflammatory reaction factor interleukin-1beta and the tumor necrosis factor-alpha, so that the dimethyl fumarate eye drops is greatly beneficial to fungal keratitis patients; and the cure rate on fungal keratitis reaches up to 95.7%.

Description

technical field [0001] The invention discloses a dimethyl fumarate eye drop, a preparation method thereof and an application as a medicine for treating fungal keratitis, belonging to the technical field of pharmacy. Background technique [0002] Fungal keratitis is an inflammatory disease of the cornea caused by fungal infection; the onset is slow and the course of the disease is long, and symptoms such as eye redness and pain, blurred vision, photophobia, tearing, and blepharospasm can occur; it can cause serious visual impairment . Agricultural trauma, long-term use of contact lenses, and overuse of broad-spectrum antibiotics and glucocorticoids have all led to an increase in its incidence year by year. Aspergillus and Fusarium are the main pathogens of fungal keratitis. After Aspergillus fumigatus infects the cornea, the corneal tissue stimulated by Aspergillus fumigatus will produce a strong immune response: corneal vasodilation, the recruitment of a large number of in...

AI Technical Summary

Problems solved by technology

That is to say, those skilled in the art have a technical prejudice that "dimethyl fumarate cannot contact the eyes", so there will be no motivation to use dimethyl fumarate for eye-related treatment; therefore, there is currently no Report on the use of dimethyl fumarate for eye discomfort

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