Mitomycin freeze-drying preparation for injection and preparation method of mitomycin freeze-drying preparation
A technology for mitomycin and freeze-dried preparations, applied in the field of medicine, can solve the problem of high residual tert-butanol solvent, and achieve the effects of improving solid content, improving solubility and good stability
Active Publication Date: 2021-08-03
KINDOS PHARM CO LTD +1
View PDF1 Cites 4 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0044] A freeze-dried preparation of mitomycin for injection, in terms of mass, the liquid preparation raw materials include 2 mg of mitomycin, 5 mg of mannitol, 0.5 ml of tert-butanol and 0.01 ml of propylene glycol, and add water to make up to 1 ml.
Embodiment 2
[0046] A freeze-dried preparation of mitomycin for injection, in terms of mass, the liquid preparation raw materials include 4 g of mitomycin, 6 g of mannitol, 0.7 L of tert-butanol and 0.03 L of propylene glycol, and add water to make up to 1 L.
Embodiment 3
[0048] A freeze-dried preparation of mitomycin for injection, in terms of mass, the dosing raw materials include 2.5 g of mitomycin, 5 g of mannitol, 0.6 L of tert-butanol and 0.02 L of propylene glycol, and add water to make up to 1 L.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention provides a mitomycin freeze-drying preparation for injection, wherein the mitomycin freeze-drying preparation is characterized in that the mitomycin freeze-drying preparation comprises the preparation raw materials by mass: 2-4 parts of mitomycin, 5-6 parts of mannitol, 500-700 parts of tertiary butanol, 10-30 parts of propylene glycol, and water added until the volume is 1000 parts. The product has no solvent residue problem and high stability.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a freeze-dried preparation of mitomycin for injection. Background technique [0002] Mitomycin is an antineoplastic drug isolated from the culture medium of actinomycetes. It is a commonly used periodic non-specific drug and is effective against a variety of solid tumors. It is one of the commonly used antineoplastic drugs in various countries. Mitomycin is thermally stable and has a high melting point (greater than 360°C). It is freely soluble in organic solvents and slightly soluble in water. Mitomycin is extremely unstable in aqueous solution. The degradation process is affected by acid and alkali. and temperature effects. [0003] Since mitomycin is slightly soluble in water, its solubility in water at room temperature is about 1.0 mg / mL, and the solubility decreases with decreasing temperature. The minimum specification of the marketed original research product is 5mg / bot...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More IPC IPC(8): A61K9/19A61K47/10A61K31/407A61P35/00
CPCA61K9/0019A61K9/19A61K47/10A61K31/407A61P35/00
Inventor 文娅娅谢谦史宣宇田欣欣
Owner KINDOS PHARM CO LTD