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Aluminum-magnesium-aspirin tablet (II)

A technology for aluminum-magnesium pirin tablet and aspirin, which is applied to the field of aluminum-magnesium pirin tablet and its preparation, and can solve the problems of unfavorable manufacturing cost, many processes, low β-cyclodextrin inclusion yield and the like

Active Publication Date: 2021-08-10
BEIJING CHENG JI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has many steps, and the inclusion yield of β-cyclodextrin is low, which is not conducive to controlling the manufacturing cost

Method used

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  • Aluminum-magnesium-aspirin tablet (II)
  • Aluminum-magnesium-aspirin tablet (II)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A kind of aluminum-magnesium-pirin tablet (Ⅱ) of embodiment 1

[0055] The aluminum-magnesium-pirin tablet (II) described in this embodiment is a double-layer tablet composed of an aspirin layer and a buffer layer. In the aspirin layer, 80% w / w of aspirin is Coating with premixed coating agent.

[0056] The aluminum-magnesium-pirin tablet (II) of the present embodiment is prepared by the following method:

[0057] I. Preparation of Aspirin Layer Total Granules

[0058] (1) Preparation of aspirin-coated granules

[0059] Aspirin (40-150 mesh) 200 parts by weight

[0060] IR White 12 parts by weight

[0061] 48 parts by weight of purified water

[0062] Take the prescribed amount of water, add IR White, stirred and dissolved as aspirin powder coating solution. The aspirin powder is taken and placed in a fluidized bed bottom spray coating machine for coating until the coating liquid is completely coated to obtain aspirin coated granules. The operating parameter...

Embodiment 2

[0084] Embodiment 2 a kind of aluminum-magnesium-pirin tablet (Ⅱ)

[0085] The aluminum-magnesium-pirin tablet (II) described in this embodiment is a double-layer tablet composed of an aspirin layer and a buffer layer. In the aspirin layer, 80% w / w of aspirin is Coating with premixed coating agent.

[0086] The aluminum-magnesium-pirin tablet (II) of the present embodiment is prepared by the following method:

[0087] I. Preparation of Aspirin Layer Total Granules

[0088] (1) Preparation of aspirin-coated granules

[0089] Aspirin (40-150 mesh) 200 parts by weight

[0090] IR 10 parts by weight

[0091] 2.5 parts by weight of talcum powder

[0092] Titanium dioxide 2 parts by weight

[0093] Coloring agent 1 weight part

[0094] 83.5 parts by weight of purified water

[0095] Take the prescribed amount of water, add IR, talcum powder, titanium dioxide, coloring agent, stir and disperse evenly as aspirin powder coating solution. The aspirin powder is taken and pl...

Embodiment 3

[0109] Embodiment 3 a kind of aluminum-magnesium-pirin tablet (Ⅱ)

[0110] The aluminum-magnesium-pirin tablet (II) described in this embodiment is a double-layer tablet composed of an aspirin layer and a buffer layer. In the aspirin layer, 80% w / w of aspirin is Coating with premixed coating agent.

[0111] The aluminum-magnesium-pirin tablet (II) of the present embodiment is prepared by the following method:

[0112] I. Preparation of Aspirin Layer Total Granules

[0113] (1) Preparation of aspirin-coated granules

[0114] Aspirin (40-150 mesh) 200 parts by weight

[0115] Protect 10 parts by weight

[0116] Talcum powder 3 parts by weight

[0117] Coloring agent 1 weight part

[0118] 86 parts by weight of purified water

[0119] Take the prescribed amount of water, add Protect, talcum powder, and coloring agent are used as aspirin powder coating solution after stirring and dispersing evenly. The aspirin powder is taken and placed in a fluidized bed bottom spray...

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Abstract

The invention provides an aluminum-magnesium-aspirin tablet (II) and a preparation method thereof. The aluminum-magnesium-aspirin tablet (II) is a double-layer tablet composed of an aspirin layer and a buffer layer, raw materials of the aluminum-magnesium-aspirin tablet (II) comprise an aspirin layer composition and a buffer layer composition, and the mass ratio of the aspirin layer composition to the buffer layer composition is 0.8: 1.2-1.2: 0.8; and wherein in the aspirin layer composition, 80% w / w of aspirin is coated with a premixed coating agent. According to the aluminum-magnesium-aspirin tablet (II) provided by the invention, the content of free salicylic acid is below 0.41% through 6-month accelerated stability investigation and test, and the tablet is free of phenomena such as layering and good in stability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an aluminum-magnesium-pirin tablet (II) and a preparation method thereof. Background technique [0002] Al-Mg-Pirin Tablets (Ⅱ) was first developed by the Japanese Lion Pharmaceutical Company, and was approved as an anti-platelet inhibitor in Japan on September 19, 2000, and was added in November 2005 for the treatment of Kawasaki disease. indications. The product name of the product on the market is "Buffalin compound ingot A81" (BUFFERIN). [0003] Each aluminum-magnesium-pirin tablet (Ⅱ) contains 81mg of aspirin, 22mg of heavy magnesium carbonate, and 11mg of aluminum glyoxate. The alkaline components heavy magnesium carbonate and aluminum glycolate can reduce the adverse stimulation of aspirin to the stomach, significantly reduce the incidence of gastrointestinal mucosal erosion and ulcer, and increase the absorption of aspirin. In addition, heavy mag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/24A61K31/616A61K33/10A61K47/02A61K47/38A61K47/36A61K47/26A61K47/32A61P7/02A61K31/198
CPCA61K31/616A61K33/10A61K31/198A61P7/02A61K9/2054A61K9/2018A61K9/2009A61K9/2059A61K9/209A61K9/2081A61K2300/00
Inventor 季国明童丰陶成正白钰翡鲍勇胜单联营
Owner BEIJING CHENG JI PHARMA
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