Membranous milkvetch root extract, as well as preparation and application methods thereof

An astragalus extract, a technology of Astragalus, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problems of rough production process, poor formulation stability, etc., and achieve the effect of ensuring drug safety, controllable quality, and clear material basis

Inactive Publication Date: 2012-08-22
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although Bufei Huoxue Capsule is effective in clinical use, its preparation process is to concentrate water-extracted and alcohol-settled solution into an extract, then mix it with Radix Paeoniae Rubra powder, granulate and fill capsules, and

Method used

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  • Membranous milkvetch root extract, as well as preparation and application methods thereof
  • Membranous milkvetch root extract, as well as preparation and application methods thereof
  • Membranous milkvetch root extract, as well as preparation and application methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] Example 1: In vivo intestinal perfusion method in rats to study the absorption of Astragalus

[0025] 1 Test materials

[0026] 1.1 Test equipment

[0027] Agilent 1200-UV detector; Agilent TC-C 18 (250×4.6mm, 5μm); JA2003H type one-thousandth balance (Shanghai Precision Scientific Instrument Co., Ltd.); CP225D type one-hundredthousandth electronic balance (Sartorious); TD24-WS low-speed desktop centrifuge (Xiangyi centrifuge Co., Ltd.); KL-RO-10 Eco ultrapure water machine (Taiwan Eco); WH-2 mini vortex mixer (Shanghai Huxi Analytical Instrument Factory); MTN-2800D Nitrogen Drying Apparatus (Tianjin Otsai Ens Instrument Co., Ltd.); DDB-320 electronic peristaltic pump (Shanghai Zhixin Instrument Co., Ltd.); UV spectrophotometer (model: UV-2450).

[0028] 1.2 Test reagents and drugs

[0029] Verbasil reference substance: Shanghai Tongtian Biotechnology Co., Ltd.; purity ≥98%; Formononetin reference substance: Shanghai Tongtian Biotechnology Co., Ltd.; purity ≥98%; Astragaloside ...

Example Embodiment

[0061] Example 2: Study on blood components of Astragalus

[0062] 1 Test materials

[0063] 1.1 Test equipment

[0064] Agilent 1200-UV detector; Agilent TC-C 18 (250×4.6mm, 5μm); JA2003H type one-thousandth balance (Shanghai Precision Scientific Instrument Co., Ltd.); CP225D type one-hundredthousandth electronic balance (Sartorious); TD24-WS low-speed desktop centrifuge (Xiangyi centrifuge Co., Ltd.); KL-RO-10 Eco ultra-pure water machine (Taiwan Eco); WH-2 mini-vortex mixer (Shanghai Huxi Analytical Instrument Factory); MTN-2800D Nitrogen Drying Apparatus (Tianjin Autosaien Instrument Co., Ltd.); UV spectrophotometer (model: UV-2450).

[0065] 1.2 Test reagents and drugs

[0066] Verbasil reference substance: Shanghai Tongtian Biotechnology Co., Ltd.; purity ≥98%; Formononetin reference substance: Shanghai Tongtian Biotechnology Co., Ltd.; purity ≥98%; Astragaloside IV reference substance: China Pharmaceutical and Biological Products Laboratory ; Purity ≥95%; Acetonitrile: produce...

Example Embodiment

[0080] Example 3: Study on Urine Components of Astragalus

[0081] 1 Test materials

[0082] 1.1 Test equipment

[0083] Agilent 1200-UV detector; Agilent TC-C 18 (250×4.6mm, 5μm); JA2003H type one-thousandth balance (Shanghai Precision Scientific Instrument Co., Ltd.); CP225D type one-hundredthousandth electronic balance (Sartorious); TD24-WS low-speed desktop centrifuge (Xiangyi centrifuge Co., Ltd.); KL-RO-10 Eco ultra-pure water machine (Taiwan Eco); WH-2 mini-vortex mixer (Shanghai Huxi Analytical Instrument Factory); MTN-2800D Nitrogen Drying Apparatus (Tianjin Autosaien Instrument Co., Ltd.); 3700M071 metabolic cage (Tecniplast company); UV spectrophotometer (model: UV-2450).

[0084] 1.2 Test reagents and drugs

[0085] Verbasil reference substance: Shanghai Tongtian Biotechnology Co., Ltd.; purity ≥98%; Formononetin reference substance: Shanghai Tongtian Biotechnology Co., Ltd.; purity ≥98%; Astragaloside IV reference substance: China Pharmaceutical and Biological Products La...

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PUM

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Abstract

The invention provides a membranous milkvetch root extract, as well as preparation and application methods thereof. The extract is extracted by taking traditional Chinese medicine membranous milkvetch root as a raw material, and the extract contains the following components in percentage by weight: 0.66%-0.73% of calycosin, 0.36%-0.42% of onocol and 34.6%-36.9% of total saponins from membranous milkvetch root. The preparation method of the extract disclosed by the invention takes the content of the calycosin, the content of the onocol, the content of the total saponins from the membranous milkvetch root, the water content, the residue on ignition and the content of heavy metals in the extract as indexes for optimization. According to the preparation method provided by the invention, the quality of the membranous milkvetch root extract can be better controlled, the safety in medication can be ensured, and membranous milkvetch root medicaments with controllable quality and clear material base can be deeply developed for complying with the requirements of traditional Chinese medicine modernization.

Description

technical field [0001] The invention relates to an extract of Astragalus membranaceus, in particular to the extract using the traditional Chinese medicine Astragalus membranaceus as a raw material, a preparation method thereof and an application for preparing a medicament for treating chronic obstructive pulmonary disease; it belongs to the field of medicines. Background technique [0002] COPD, or chronic obstructive pulmonary disease (COPD), is defined as chronic bronchitis and / or emphysema characterized by airflow obstruction. In my country, COPD is the main underlying disease of pulmonary heart disease, and the deaths caused by COPD can reach 1 million people every year. Its harm is quite serious. [0003] The chemical drugs currently used to treat COPD are single-target preparations, mainly to relieve disease symptoms, and there is no effective treatment to delay the course of COPD or inhibit small airway and lung parenchymal inflammation. The existing product on the ...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P11/00A61K125/00
Inventor 程泽能蔡凝芳袁玉云筠筠张弘王霆
Owner CENT SOUTH UNIV
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