Ephedra-cassia twig medicine pair traditional Chinese medicine formula granules and preparation method thereof

A technology of traditional Chinese medicine formula granules and ephedra, applied in the direction of medical formula, medical raw materials derived from ephedra, medical preparations containing active ingredients, etc., to achieve the effects of ensuring accuracy, increasing inclusion rate, and reducing dosage

Pending Publication Date: 2021-08-10
GUANGDONG YIFANG PHARMA +2
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current research on the ephedra-cinnamon twig medicine pair mainly focuses on the chemical components and pharmacological effects (see CNKI), and there are no literature reports on the preparation of the ephedra-guizhi medicine pair traditional Chinese medicine formula granules and related products.

Method used

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  • Ephedra-cassia twig medicine pair traditional Chinese medicine formula granules and preparation method thereof
  • Ephedra-cassia twig medicine pair traditional Chinese medicine formula granules and preparation method thereof
  • Ephedra-cassia twig medicine pair traditional Chinese medicine formula granules and preparation method thereof

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preparation example Construction

[0034] The embodiment of the present invention provides a preparation method of ephedra-cinnamon twig medicine pair traditional Chinese medicine formula granules, the preparation method comprising the following steps:

[0035] Mix ephedra and cassia twig, distill with water, collect volatile oil, aromatic water and mixed medicinal residue;

[0036] Decocting the combined medicinal residue with water, collecting the extract, concentrating, mixing the obtained clear paste with pharmaceutical excipient A, and drying to prepare extract powder;

[0037] The volatile oil is clathrated with the mixed solution of the aromatic water and the clathrate, and the clathrate obtained is dried to prepare the clathrate, and the clathrate adopts the method of stirring clathrate and grinding clathrate to circulate each other;

[0038]The extract powder, the clathrate, the pharmaceutical excipient B and the pharmaceutical excipient C are mixed and granulated. The embodiment of the present invent...

Embodiment 1

[0067] The present embodiment provides a kind of preparation method of ephedra-cinnamon twig medicine formula granules for traditional Chinese medicine, comprising the following steps (see figure 1 ):

[0068] a. Weigh 60kg each of ephedra and cassia twig decoction pieces, add 3 times the amount of water, soak for 2 hours, steam distill for 3 hours, and collect the distillate; after standing for 3 hours, the distillate is separated to obtain volatile oil and aroma water.

[0069] b. Take the above-mentioned medicinal residue after distillation, heat and decoct twice, add 8 times the amount of water for the first time, decoct for 1 hour; add 6 times the amount of water for the second time, decoct for 1 hour, and filter the decoction Cross (cross 350 mesh sieve), merge to get "ephedra-cinnamon twig extract".

[0070]c. Take the above-mentioned ephedra-guizhi extract, concentrate it under reduced pressure (-0.85MPa) at 80°C to a clear cream with a relative density of 1.06, and ...

Embodiment 2

[0083] The present embodiment provides a kind of preparation method of ephedra-cinnamon twig medicine formula granules for traditional Chinese medicine, comprising the following steps (see figure 1 ):

[0084] a. Weigh 60kg each of ephedra and cassia twig decoction pieces, add 5 times the amount of water, soak for 2 hours, steam distill for 3 hours, and collect the distillate; after the distillate stands for 3 hours, separate the volatile oil and aroma water.

[0085] b. Take the above-mentioned medicinal residue after distillation, heat and decoct twice, add 8 times the amount of water for the first time, decoct for 1 hour; add 6 times the amount of water for the second time, decoct for 1 hour, and filter the decoction Cross (cross 350 mesh sieve), merge to get "ephedra-cinnamon twig extract".

[0086] c. Take the above-mentioned ephedra-guizhi extract, concentrate it under reduced pressure (-0.85MPa) at 80°C to a clear cream with a relative density of 1.06, and obtain "Eph...

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Abstract

The invention relates to a preparation method of herba ephedrae-cassia twig medicine pair traditional Chinese medicine formula granules, which comprises the following steps: mixing herba ephedrae and cassia twig, distilling the mixture with water vapor, and collecting volatile oil, aromatic water and mixed medicine residues; decocting the mixed medicine residue with water, collecting an extracting solution, concentrating the solution, and drying the obtained clear paste and a pharmaceutical adjuvant A to prepare extract powder; subjecting the volatile oil to clathration with a mixed solution of the aromatic water and the clathration agent, and drying an obtained clathration solution to prepare a clathrate compound, wherein clathration adopts a mode of combining stirring clathration and grinding clathration; and mixing the extract powder, the clathrate compound, the pharmaceutic adjuvant B and the pharmaceutic adjuvant C, and granulating the total mixture. By adopting the preparation method, the volatile components of the ephedra and the cassia twig can be effectively reserved, the loss of the cassia twig in the preparation step can be reduced. According to the invention, the ephedra-cassia twig medicine pair traditional Chinese medicine formula granule which can be clinically blended is provided.

Description

technical field [0001] The invention relates to methods for extracting and preparing preparations of traditional Chinese medicines, in particular to a traditional Chinese medicine formula granule of ephedra-cinnamon twigs and a preparation method thereof. Background technique [0002] Traditional Chinese medicine formula granules are made of single-flavored traditional Chinese medicine decoction pieces, extracted, concentrated and granulated by modern pharmaceutical technology. They are used in clinical formulas of traditional Chinese medicine. Etc. Under the background of the implementation of national standards for TCM formula granules and the end of the pilot production of TCM formula granules, as a modern new type of decoction pieces, TCM formula granules have gradually replaced traditional decoction pieces and become the preferred method of medication for the public. [0003] The medicine pair is refined through repeated practice by physicians of the past dynasties, co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61K9/16A61J3/00A61P11/00A61K36/17
CPCA61K36/17A61K36/54A61K9/1623A61K9/1652A61J3/00A61K9/1682A61P11/00A61K2300/00
Inventor 梁志毅徐杰程学仁黄梦婷彭帮贵刘佩仪梁丽金孙冬梅
Owner GUANGDONG YIFANG PHARMA
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