Application of LRG1 gene or protein coded by LRG1 gene in preparation of medicine for reducing autotransplantation fat cell apoptosis

A fat cell and autologous transplantation technology, applied in the field of medicine, can solve the problems of poor survival effect of autologous fat transplantation, and achieve the effects of reducing fat cell apoptosis, low synthesis cost and promoting survival.

Pending Publication Date: 2021-08-13
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Claims
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Problems solved by technology

[0005] The present invention proposes the application of the LRG1 gene or its encoded protein in the preparation of drugs for reducing the apoptosis of autologous fat cells, which solves the problem of poor survival effect of autologous fat transplantation in the prior art

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  • Application of LRG1 gene or protein coded by LRG1 gene in preparation of medicine for reducing autotransplantation fat cell apoptosis
  • Application of LRG1 gene or protein coded by LRG1 gene in preparation of medicine for reducing autotransplantation fat cell apoptosis
  • Application of LRG1 gene or protein coded by LRG1 gene in preparation of medicine for reducing autotransplantation fat cell apoptosis

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Embodiment 1

[0030] Scheme 1: The application of LRG1 gene as a drug target in the preparation of drugs for reducing apoptosis of autologous transplanted adipocytes.

[0031] Scheme 2: The application of the protein encoded by the LRG1 gene as a drug target in the preparation of a drug for reducing the apoptosis of autologous transplanted adipocytes.

[0032] Scheme 3: Application of human LRG1 recombinant protein in the preparation of drugs for reducing apoptosis of autologous transplanted adipocytes.

[0033] Scheme 4: An injection comprising a protein encoded by the LRG1 gene. details as follows:

[0034] 1. Experimental materials

[0035] 1.1 The preparation method of human LRG1 recombinant protein injection is as follows:

[0036] LRG1 recombinant protein was purchased from R&D (7890-LR), dissolved in saline, and prepared into solutions with concentrations of 1 μg / ml and 5 μg / ml, respectively.

[0037] 2. Experimental method

[0038] 2.1 Collection and processing of human fat sam...

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Abstract

The invention provides application of an LRG1 gene or a protein coded by the LRG1 gene in preparation of a medicine for reducing autotransplantation fat cell apoptosis. The administration mode of the medicine is local injection or mixing of the medicine in transplanted adipose tissue before transplantation. When the human LRG1 recombinant protein is applied to autologous fat transplantation, apoptosis of transplanted fat cells is reduced, and the survival of fat grafts at transplanted parts is promoted. The related medicine directly aims at fat cells, inhibits apoptosis of transplanted fat cells, and has a better treatment effect. Compared with the existing medicine, the medicine provided by the invention has a remarkable advantage in cost and is relatively low in synthesis cost.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of the LRG1 gene or its encoded protein in the preparation of medicines for reducing the apoptosis of autologous transplanted adipocytes. Background technique [0002] There are more than 10 million new cases of soft tissue defects in the world every year, and there are more than 1 million cases of severe soft tissue defects after mastectomy for breast cancer. At present, there are two kinds of materials commonly used in clinical soft tissue defect repair: autologous tissue and synthetic materials. Because synthetic artificial materials have defects such as poor tissue compatibility, obvious contour feeling, and non-permanent implantation, their wider application is limited. Adipose tissue is the most commonly used autologous soft tissue repair material, and its free transplantation is one of the most commonly used soft tissue defect repair methods in plastic s...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K9/00A61K38/17A61P37/06
CPCA61K45/00A61K38/1741A61K9/0019A61K9/0024A61P37/06
Inventor 张艺凡高雅侯家康李青峰
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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