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Anti-Gram-positive bacteria compound derived from polar source fungi, and preparation method and application thereof

A compound and fungal technology, applied in the field of biomedicine, can solve problems such as drug resistance

Active Publication Date: 2022-08-02
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Drug resistance to vancomycin, which is now commonly used in clinical practice, has gradually emerged

Method used

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  • Anti-Gram-positive bacteria compound derived from polar source fungi, and preparation method and application thereof
  • Anti-Gram-positive bacteria compound derived from polar source fungi, and preparation method and application thereof
  • Anti-Gram-positive bacteria compound derived from polar source fungi, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Embodiment 1, the preparation of anti-Gram-positive bacteria compound and its anti-Gram-positive bacteria activity

[0102] 1. Preparation of anti-Gram-positive bacteria compounds by fermentation

[0103] 1. Isolation and identification of Neonectria sp. CPCC 401225

[0104] 1.1 Neonectria sp. CPCC 401225 was isolated from samples isolated from Arctic moss (Sanionia uncinata (Hedw.) Loeske). The method is as follows: Collect arctic moss, put it in a ziplock bag, and bring it back to the laboratory for processing. 1 g of young roots were weighed, rinsed with 75% ethanol aqueous solution for 30 s, washed with sterile water for 3 times, chopped with sterile scissors, put into a sterilized mortar and ground with quartz sand. Add the grinding solution to a centrifuge tube filled with 9 mL of sterile water, and the sample dilution is 10 -1 , after shaking well, make 10 in turn -2 , 10 -3 , 10 -4 , 10 -5 serial dilutions. Pipette 200 μL of different gradient dilutions ...

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Abstract

The invention discloses an anti-Gram-positive bacteria compound derived from a polar source fungus and a preparation method and application thereof. The anti-Gram-positive bacteria compound of the present invention is derived from a fungus of the genus Neonectria (Neonectria sp.) CPCC 401225 of polar origin, and its registration number in the General Microbiology Center of the China Microorganism Culture Collection Management Committee is CGMCC No. 20277. In the present invention, Enniantins with good anti-Gram-positive bacteria activity are isolated and obtained from the fungi of the genus Neonectria for the first time. The compound represented by the formula I or II or III of the present invention has a simple preparation process, and is suitable for the research of anti-Gram-positive bacteria lead compounds or the preparation of anti-Gram-positive bacteria drugs.

Description

technical field [0001] The invention relates to an anti-Gram-positive bacteria compound derived from a polar source fungus in the field of biomedicine and a preparation method and application thereof. Background technique [0002] Gram-positive bacteria are an important class of pathogenic bacteria. In recent years, the increase in the infection rate of Gram-positive cocci is one of the clinical concerns for serious infectious diseases of the respiratory system. Such bacteria are widely distributed and spread rapidly. , will bring great difficulties to clinical treatment. [0003] In recent years, due to the abuse of antibiotics and other reasons, the phenomenon of drug resistance has increased year by year. Staphylococcus and enterococcus are more serious than other gram-positive bacteria, and can easily cause endocarditis and sepsis. Among them, the resistance of methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE) an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/14A61K36/06A61K31/33A61P31/04A23L31/00A23L33/00A23K10/16A23K20/137C12P17/14C12R1/645
CPCC12N1/14A61K36/06A61K31/33A61P31/04A23L31/00A23L33/00A23K10/16A23K20/137C12P17/14A23V2002/00A23V2200/30Y02A50/30
Inventor 张涛余利岩何文妮毛会金柏菁璘
Owner MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI