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The application of timp3 in the diagnosis of anxiety and depression

A technology for depression and anxiety, applied in the field of biomedicine, can solve problems such as lack of biomarkers, dysfunction, and incompletely clear etiology of anxiety and depression, and achieve high diagnostic value

Active Publication Date: 2022-05-17
ACADEMY OF MILITARY MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the pathogenesis of anxiety suppression disorder is complex, involving multi-system and multi-link dysfunction, which can be manifested as abnormal dynamic balance of various biochemical substances
Unfortunately, the etiology of anxiety and depression is still not completely clear, and the diagnosis of anxiety and depression is still based on clinical manifestations and scales. At present, there is still a lack of biological evidence related to the diagnosis of anxiety and depression. Objective indicators such as markers

Method used

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  • The application of timp3 in the diagnosis of anxiety and depression
  • The application of timp3 in the diagnosis of anxiety and depression
  • The application of timp3 in the diagnosis of anxiety and depression

Examples

Experimental program
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Embodiment 1

[0036] Example 1 Cytokine Chip Screening for Differential Proteins

[0037] From April to November 2012, 5ml of median cubital venous blood was obtained from the PLA General Hospital of young men who faced greater mental and psychological stress during a long-term (7-month) mission. , stand at room temperature for 30 minutes, centrifuge at 1000×g for 15 minutes, and collect serum (including 8 cases of control samples before performing the task, and the initial letter of the number is B; 12 samples after the task, the initial letter of the number is X). The AAH-BLG-1 cytokine chip of Raybiotech Company was used to screen the target protein from 507 factors. The readout result is the fluorescence intensity, and after normalization, the higher the value, the higher the protein concentration. The results showed that compared with the control group, TIMP3 in the serum after performing the task increased significantly (t test p=0.00095) ( figure 1 ), intending to use TIMP3 as a de...

Embodiment 2

[0042] Embodiment 2 clinical verification

[0043] 1. Sampling

[0044] Take 20 patients with depression and anxiety syndrome from June 2019 to August 2019 in the First Medical Center of PLA General Hospital, and 19 patients with depression and anxiety syndrome in Chengdu Fourth People's Hospital in October 2020, a total of 39 cases; Collect 20 patients with schizophrenia who visited the Fourth People's Hospital of Chengdu in October 2020 as controls. The healthy controls were obtained from physical examinations at the First Medical Center of the PLA General Hospital from June 2019 to August 2019, but all indicators were normal. volunteers, a total of 20 cases. Obtain 5ml of cubital median venous blood from all subjects, let it stand at room temperature for 30 minutes, centrifuge at 1000×g for 15 minutes, and collect serum for cytokine chip.

[0045] The result is as figure 2 As shown, compared with the normal group, the serum TIMP-3 of the patients with anxiety and depressi...

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Abstract

The invention relates to the field of biomedicine, and discloses the application of a reagent for detecting the expression level of TIMP3 gene or protein in preparing products for diagnosing anxiety and depression or distinguishing anxiety and depression from schizophrenia. The present invention proves that TIMP3 is highly expressed in patients with anxiety and depression through a large number of clinical samples. Clinical applications such as treatment and drug therapy provide therapeutic targets and important basis.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of TIMP3 in the diagnosis of anxiety and depression. Background technique [0002] Neurosis can also be called neurosis or psychoneurosis, which is a general term for a group of mental disorders, such as neurasthenia, obsessive-compulsive disorder, anxiety disorder, phobia, and somatoform disorder. The main feature of the clinical manifestations of neurosis is that patients often feel pain, affect psychological function or social function, without any organic pathological basis, most of them will have mental and psychological abnormalities, and sometimes it may cause heart, gastrointestinal or reproductive system. Lesions, will continue to protracted onset. [0003] Clinically, a term is often used called neurosis, which is very broad, and it is also called neurosis, or psychoneurosis. It is not a single disease, but a general term for a group of diseases. Including n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68G01N33/58G01N33/577G01N33/543A61K45/00A61P25/22A61P25/24
CPCG01N33/6893G01N33/587G01N33/577G01N33/54306A61K45/00A61P25/22A61P25/24G01N2800/301G01N2800/302
Inventor 程倩倩张纪岩何佳陈娟杨锡琴董洁牛春晓曹俊霞
Owner ACADEMY OF MILITARY MEDICAL SCI