Preparation method of water-soluble magnetic sphere

A water-soluble, magnetic sphere technology, applied in the field of macro-scale preparation of magnetic nano-microspheres, can solve problems such as poor dispersibility, and achieve the effects of good magnetic susceptibility, easy scale-up production, and simple and easy-to-obtain raw materials

Pending Publication Date: 2021-08-27
广州康臣药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The SPION prepared by the traditional SPION prepa

Method used

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  • Preparation method of water-soluble magnetic sphere
  • Preparation method of water-soluble magnetic sphere
  • Preparation method of water-soluble magnetic sphere

Examples

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Example Embodiment

[0049] The present invention provides a method of preparing a water soluble magnetic ball comprising the steps of:

[0050] Preparation of citric acid modified oil-soluble tetrasoxide three iron nanoparticles, supplied hydroxyethyl starch or / and glucan solution, adding the hydroxyethyl starch or / and glucan solution to the decoration of citric acid The oil-soluble tetracted three iron nanoparticle solution is reacted to collect water soluble magnetic balls;

[0051] Among them, the steps of preparing the oil-soluble tetrasoxide three-iron nanoparticle solution modified by citric acid include:

[0052] The oil-soluble nanopartrioma solution wrapped in oleic acid was prepared, and a citric acid solution was provided, and the citric acid solution droplets were added to the oil-soluble tetraned iron nanoparticle solution of the oleic acid with stirring. The resulting product was mixed with methyl tert-butyl ether to collect precipitation.

[0053] It will be appreciated that in ord...

Example Embodiment

[0077] Example 1:

[0078] A method of preparing small particle soluble magnetic balls, is achieved by the following steps:

[0079] (1) take 10.8g of ferric chloride hexahydrate was dissolved in 36.5g of sodium oleate 80mL of anhydrous ethanol, 60 mL of deionized water and a mixed solvent consisting of 140mL of n-hexane, magnetic stirring, temperature was raised to 70 ℃, reflux condenser The reaction 4h, a separatory funnel and the upper organic layer was taken, washed with 30mL three times with deionized water, hexane and water removed by rotary evaporation to give a viscous reddish brown iron - oleate complex;

[0080] (2) from step (1) prepared in iron - 36g of oleic acid and 64.4g complex and oleyl alcohol ether miscible 200g, magnetic stirring, temperature 100 deg.] C under vacuum deaerator 1h and heated to 200 ℃ thermostat 0.5h, to give a black liquid, 25g 250g the reaction was precipitated with acetone, 7000rpm centrifugal 25min, dried 110 ℃, tri-iron tetroxide to give ult...

Example Embodiment

[0084] Example 2:

[0085] A method of preparing small particle soluble magnetic balls, is achieved by the following steps:

[0086] (1) take 10.8g of ferric chloride hexahydrate was dissolved in 36.5g of sodium oleate 80mL of anhydrous ethanol, 60 mL of deionized water and a mixed solvent consisting of 140mL of n-hexane, magnetic stirring, temperature was raised to 70 ℃, reflux condenser The reaction 4h, a separatory funnel and the upper organic layer was taken, washed with 30mL three times with deionized water, hexane and water removed by rotary evaporation to give a viscous reddish brown iron oleate complex;

[0087] (2) from step (1) prepared in iron - 64.4g and 36g of oleic acid and oleyl alcohol ether miscible 200g, magnetic stirring, temperature 100 deg.] C under vacuum deaerator 1h and heated to 200 ℃ temperature 0.5h, to give a dark liquid, 25g 250g the reaction was precipitated with acetone, 7000rpm centrifugal 25min, dried 110 ℃, tri-iron tetroxide to give ultra-small p...

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Abstract

The invention relates to a preparation method of a water-soluble magnetic sphere. The preparation method comprises the following steps: adding a hydroxyethyl starch or/and glucan solution into a citric acid modified oil-soluble ferroferric oxide nanoparticle solution to react, and collecting the water-soluble magnetic sphere. The step of preparing the citric acid-modified oil-soluble ferroferric oxide nanoparticle solution comprises: preparing an oleic acid-coated oil-soluble ferroferric oxide nanoparticle solution, providing a citric acid solution, dropwise adding the citric acid solution into the oleic acid-coated oil-soluble ferroferric oxide nanoparticle solution under stirring, stirring for reacting, mixing the obtained product with methyl tert-butyl ether, and collecting the precipitate. The purpose of macroscopically preparing the water-soluble SPION which is good in dispersity, good in magnetic susceptibility, high in magnetic saturation intensity and free of residual magnetism is achieved.

Description

technical field [0001] The invention relates to the field of macro-preparation of magnetic nano microspheres, in particular to a preparation method of water-soluble magnetic spheres. Background technique [0002] Nanomaterials have surface effect, small size effect, quantum size effect and macroscopic quantum tunneling effect, which make them a hot research object. Due to its unique superparamagnetism, low toxicity and good biocompatibility, superparamagnetic iron oxide nanoparticles (SPION) have become a new focus in the field of medical nanomaterials and targeting research at home and abroad in recent years. Magnetic resonance imaging (MRI), magnetic hyperthermia, cell labeling and imaging, and targeted drug delivery, etc. [0003] The application of SPION in medicine needs to consider three important factors: colloidal stability, biocompatibility and plasma half-life. Among them, the influencing factor of the colloidal stability is the size of the iron oxide crystal nuc...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K47/36A61K49/12A61K49/18H01F41/02
CPCA61K47/02A61K47/36A61K49/126A61K49/1818H01F41/02
Inventor 万江山张焕宁晓辉郭静芳段婷婷李政海朱荃
Owner 广州康臣药业有限公司
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