Preparation method of polydioxanone copolymer coated magnetic-particles

A technology of dioxane copolymer and polydioxanone, which is applied in the directions of non-active ingredient medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc. Hexacyclic ketone has strong crystalline properties, poor solubility and other problems, and achieves the effects of uniform distribution, high saturation magnetic intensity and controllable particle size.

Inactive Publication Date: 2016-03-09
UNIV OF ELECTRONICS SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a method for preparing magnetic particles coated with polydioxanone copolymer, which aims to solve the strong crystallization performance and poor solubility of polydioxanone. Problems limited by magnetic particles

Method used

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  • Preparation method of polydioxanone copolymer coated magnetic-particles
  • Preparation method of polydioxanone copolymer coated magnetic-particles
  • Preparation method of polydioxanone copolymer coated magnetic-particles

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preparation example Construction

[0028] A method for preparing magnetic particles coated with polydioxanone copolymer, the method for preparing magnetic particles coated with polydioxanone copolymer comprises:

[0029] S101: Dissolve a certain amount of polydioxanone copolymer in 1-50ml of acetonitrile, and disperse magnetic particles with hydroxyl groups or small molecules on the surface in 1-50ml of organic solvent. The concentration of the magnetic particles is 0.1-10mg / ml, and add polydioxanone copolymer solution and mix under stirring condition;

[0030] S102: Add 10-1000ml of aqueous solution (pH7.4 phosphate buffer solution (PBS), 0.1-5% PVA aqueous solution, 1-30% PEG aqueous solution, or 0.1-10% sodium lauryl sulfate to the mixed solution at room temperature, Poloxamer and other emulsifier aqueous solution) stirring;

[0031] S103: Evaporate the organic solvent at room temperature and pressure or under reduced pressure, magnetically separate or centrifuge, wash with deionized water several times, fr...

Embodiment 1

[0042] 1) 0.5 g of mPEG-PDDO (mPEG molecular weight 5k, accounting for molecular weight 75%) was dissolved in 5 ml of acetonitrile, and oleic acid-modified iron ferric oxide nanoparticles (2 mg) were dispersed in 2 ml of n-heptane solution, and the two phases were mixed and stirred .

[0043] 3) Add the mixed solution dropwise into 70ml of PBS buffer solution, and stir at 500 rpm.

[0044] 3) The organic solvent was evaporated under reduced pressure, magnetically separated, and washed several times with deionized water.

[0045] 4) Vacuum drying at room temperature for 48 hours.

Embodiment 2

[0047] 1) Dissolve 1 g of mPEG-PDDO-mPEG (mPEG molecular weight 5k, accounting for 50% of molecular weight) in 4 ml of dimethyl sulfoxide, disperse 2 mg of hydroxyl-modified iron ferric oxide nanoparticles in 2 ml of dimethyl sulfoxide, and mix the two phases Stir.

[0048] 2) Add the mixed solution dropwise into the 10% PEG solution, and stir at 600 rpm.

[0049] 3) The organic solvent was evaporated under reduced pressure, magnetically separated, and washed several times with deionized water.

[0050] 4) Vacuum drying at room temperature for 48 hours.

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Abstract

The invention discloses a preparation method of polydioxanone copolymer coated magnetic-particles. A certain amount of a polydioxanone copolymer is dissolved in acetonitrile, the magnetic-particles modified with hydroxyl groups or small molecules on the surfaces are dispersed in an organic solvent and are added into the polydioxanone copolymer solution, and mixing is performed under the stirring condition; an aqueous solution is added into the mixed solution stir at room temperature; the organic solvent is volatilized at the room temperature and under the normal pressure or the reduced pressure, magnetic separation or centrifugal separation is performed, cleaning is performed by using deionized water for several times, and low-temperature freeze drying or room-temperature vacuum drying is performed. The prepared polydioxanone copolymer coated ferroferric oxide particles are uniform in particle size and good in dispersion, are divided into two types of micron scale (1-100 microns) and nanoscale (30-500 nanometers), and the magnetic saturation intensity is high and is sufficient for magnetic separation.

Description

technical field [0001] The invention belongs to the technical field of preparation of nano- and micron-scale polymer-coated ferrite magnetic particles, and in particular relates to a method for preparing magnetic particles coated with polydioxanone copolymer. Background technique [0002] Poly(1,4-dioxan-2-one) (PPDO), also known as polydioxanone or polydioxanone, is an aliphatic polyether ester, and its molecular structure contains Ester bonds also contain ether bonds, which have good biocompatibility and biodegradability, and are successfully used in surgical sutures, bone tissue repair materials and drug sustained release materials, especially in anticancer drugs, heart disease drugs and hypertension drugs It also shows its unique advantages in systems that require long-term drug administration. In the drug delivery system, in order to increase the targeting of drugs, magnetic nanoparticles are often added, using their unique superparamagnetic properties, to play the rol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/16A61K47/02A61K47/34
CPCA61K9/1641A61K41/00
Inventor 刘钰谢茂琼许进山李阳阳静旋郝建原
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
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