Application and method of superoxide dismutase to preparation of medicine for treating psoriasis

A technology for superoxide and psoriasis is applied in the application field of superoxide dismutase in the preparation of medicines for treating psoriasis, which can solve the problems of difficult application of psoriasis treatment, no significant effect, etc. The degree of skin keratinization, inhibition of cell cycle, excellent effect of use

Active Publication Date: 2021-08-31
广州研展科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Superoxide dismutase, as a protein with antioxidant effect, is also difficult to apply it in the treatment of psoriasis according to the prediction of those skilled in the art, and the inventors have found through experiments that common superoxide dismutase In the treatment of psoriasis, there is no significant effect

Method used

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  • Application and method of superoxide dismutase to preparation of medicine for treating psoriasis
  • Application and method of superoxide dismutase to preparation of medicine for treating psoriasis
  • Application and method of superoxide dismutase to preparation of medicine for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The preparation method of medicine for treating psoriasis, concrete steps are as follows:

[0066] (1) Prepare 2× aqueous matrix components: Add glycerin and propylene glycol to deionized water sterilized at 121°C for 15 minutes so that the concentrations of the two are 2.0% and 1.0%, respectively, and denote it as "A";

[0067] (2) Prepare 10× sodium hyaluronate components: dissolve sodium hyaluronate in deionized water sterilized at 121°C for 15 minutes to make the concentration of sodium hyaluronate 2.5%, and use 0.45uM microporous filter membrane, denoted as "B";

[0068] (3) Prepare 100× potassium sorbate component: dissolve potassium sorbate in deionized water sterilized at 121°C for 15 minutes to make the final concentration 10%, and filter with a 0.45uM microporous membrane. Denoted as "C";

[0069] (4) Prepare 200× myristoyl hexapeptide components: dissolve myristoyl hexapeptide in deionized water sterilized at 121°C for 15 minutes to make the final concentra...

Embodiment 2

[0092] The preparation method of the medicine for treating psoriasis is as follows:

[0093] (1) Prepare 2× aqueous matrix components: Add glycerin and propylene glycol to deionized water sterilized at 115°C for 20 minutes so that the concentrations of the two are 2.0% and 1.0% respectively, and denoted as "A";

[0094] (2) Prepare 10× sodium hyaluronate components: dissolve sodium hyaluronate in deionized water sterilized at 115°C for 20 minutes to make the concentration of sodium hyaluronate 2.5%, and use 0.45uM microporous filter membrane, denoted as "B";

[0095] (3) Prepare 100× potassium sorbate component: dissolve potassium sorbate in deionized water sterilized at 115°C for 20 minutes to make the final concentration 10%, and filter with a 0.45uM microporous membrane. Denoted as "C";

[0096] (4) Prepare 200× myristoyl hexapeptide components: dissolve myristoyl hexapeptide in deionized water sterilized at 115°C for 20 minutes to make the final concentration 1 mg / ml, wh...

Embodiment 3

[0107] The preparation method of the medicine for treating psoriasis is as follows:

[0108] (1) Prepare 2× aqueous matrix components: Add glycerin and propylene glycol to deionized water sterilized at 125°C for 12 minutes so that the concentrations of the two are 2.0% and 1.0%, respectively, and this component is recorded as " Component A";

[0109] (2) Prepare 10× sodium hyaluronate components: dissolve sodium hyaluronate in deionized water sterilized at 125°C for 12 minutes, so that the concentration of sodium hyaluronate is 2.5%, and use 0.45uM microporous filter membrane, this component is recorded as "component B";

[0110] (3) Prepare 100× potassium sorbate component: dissolve potassium sorbate in deionized water sterilized at 125°C for 12 minutes to make the final concentration 10%, and filter with a 0.45uM microporous membrane. This component is denoted as "Component C";

[0111] (4) Prepare 200× myristoyl hexapeptide component: dissolve myristoyl hexapeptide in de...

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Abstract

The invention belongs to the technical field of application of enzyme preparations, and particularly relates to an application of superoxide dismutase to preparation of a medicine for treating psoriasis and an application method. The superoxide dismutase disclosed by the invention is a protein amino acid sequence of the superoxide dismutase cloned from geobacillus stearothermophilus, the 20th aspartic acid is mutated into glycine, and the 141st leucine is mutated into asparagine; the CPP sequence YGRKKRRQRRR on an HIV-1 peptide fragment and superoxide dismutase are subjected to coupled expression, and the membrane crossing ability is given to the HIV-1 peptide fragment; and the CPP sequence is a Trans-activating transcriptional activator sequence. The application has the following beneficial effects: (1) the key raw material superoxide dismutase adopted in the invention is a protein in nature, is high in safety and has no side effect on human body; (2) the product has an excellent use effect, and stubborn psoriasis can be cured after the product is sprayed for about half a month; and (3) compared with expensive medicines for treating psoriasis, the product cost is low.

Description

technical field [0001] The invention belongs to the technical field of application of enzyme preparations, and in particular relates to the application of superoxide dismutase in the preparation of medicines for treating psoriasis, and also relates to the above-mentioned application method. Background technique [0002] Psoriasis (psoriasis) is a chronic, refractory and easily relapsed immune skin disease. It is hereditary. It is mainly manifested as skin erythema and plaques, covered with silvery white scales. Sites include the trunk, extremities, and scalp. At present, there is no medicine that can cure the disease, only by effectively controlling the development of the disease and alleviating the disease. [0003] Commonly used drugs in clinical practice include: [0004] Tars, anthralin, corticosteroids; methotrexate, hydroxyurea, ethyleneimine, ethimorph; [0005] In recent years, acitretin, which has been widely used in patients with psoriasis, has relatively large ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/44A61K9/08A61K47/10A61K47/36A61K47/42A61P17/06
CPCA61K38/446A61K9/0014A61K9/08A61K47/36A61K47/42A61K47/10C12Y115/01001A61P17/06
Inventor 夏勇
Owner 广州研展科技有限公司
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