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Application and method of superoxide dismutase in preparation of medicine for treating psoriasis

A technology of superoxide and dismutase, applied in biochemical equipment and methods, oxidoreductase, drug combination, etc., can solve the problems of ineffective and difficult to apply psoriasis treatment, etc., to inhibit cell cycle, The effect of reducing the degree of skin keratinization and high safety

Active Publication Date: 2022-05-06
广州研展科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Superoxide dismutase, as a protein with antioxidant effect, is also difficult to apply it in the treatment of psoriasis according to the prediction of those skilled in the art, and the inventors have found through experiments that common superoxide dismutase In the treatment of psoriasis, there is no significant effect

Method used

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  • Application and method of superoxide dismutase in preparation of medicine for treating psoriasis
  • Application and method of superoxide dismutase in preparation of medicine for treating psoriasis
  • Application and method of superoxide dismutase in preparation of medicine for treating psoriasis

Examples

Experimental program
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Effect test

Embodiment 1

[0065] The preparation method of medicine for treating psoriasis, concrete steps are as follows:

[0066] (1) Prepare 2× aqueous matrix components: Add glycerin and propylene glycol to deionized water sterilized at 121°C for 15 minutes so that the concentrations of the two are 2.0% and 1.0%, respectively, and denote it as "A";

[0067] (2) Prepare 10× sodium hyaluronate components: dissolve sodium hyaluronate in deionized water sterilized at 121°C for 15 minutes to make the concentration of sodium hyaluronate 2.5%, and use 0.45uM microporous filter membrane, denoted as "B";

[0068] (3) Prepare 100× potassium sorbate component: dissolve potassium sorbate in deionized water sterilized at 121°C for 15 minutes to make the final concentration 10%, and filter with a 0.45uM microporous membrane. Denoted as "C";

[0069] (4) Prepare 200× myristoyl hexapeptide components: dissolve myristoyl hexapeptide in deionized water sterilized at 121°C for 15 minutes to make the final concentra...

Embodiment 2

[0092] The preparation method of medicine for treating psoriasis is as follows:

[0093] (1) Prepare 2× aqueous matrix components: Add glycerin and propylene glycol to deionized water sterilized at 115°C for 20 minutes so that the concentrations of the two are 2.0% and 1.0% respectively, and denoted as "A";

[0094] (2) Prepare 10× sodium hyaluronate components: dissolve sodium hyaluronate in deionized water sterilized at 115°C for 20 minutes to make the concentration of sodium hyaluronate 2.5%, and use 0.45uM microporous filter membrane, denoted as "B";

[0095] (3) Prepare 100× potassium sorbate component: dissolve potassium sorbate in deionized water sterilized at 115°C for 20 minutes to make the final concentration 10%, and filter with a 0.45uM microporous membrane. Denoted as "C";

[0096] (4) Prepare 200× myristoyl hexapeptide components: dissolve myristoyl hexapeptide in deionized water sterilized at 115°C for 20 minutes to make the final concentration 1 mg / ml, which ...

Embodiment 3

[0107] The preparation method of medicine for treating psoriasis is as follows:

[0108] (1) Prepare 2× aqueous matrix components: Add glycerin and propylene glycol to deionized water sterilized at 125°C for 12 minutes so that the concentrations of the two are 2.0% and 1.0%, respectively, and this component is recorded as " Component A";

[0109] (2) Prepare 10× sodium hyaluronate components: dissolve sodium hyaluronate in deionized water sterilized at 125°C for 12 minutes to make the concentration of sodium hyaluronate 2.5%, and use 0.45uM microporous filter membrane, this component is recorded as "component B";

[0110] (3) Prepare 100× potassium sorbate component: dissolve potassium sorbate in deionized water sterilized at 125°C for 12 minutes to make the final concentration 10%, and filter with a 0.45uM microporous membrane. This component is denoted as "Component C";

[0111] (4) Prepare 200× myristoyl hexapeptide component: dissolve myristoyl hexapeptide in deionized ...

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Abstract

The invention belongs to the technical field of application of enzyme preparations, and in particular relates to the application and application method of superoxide dismutase in the preparation of medicines for treating psoriasis. The superoxide dismutase of the present invention is the protein amino acid sequence of superoxide dismutase cloned from Geobacillus stearothermophilus, the 20th aspartic acid is mutated into glycine, and the 141st leucine The acid is mutated into asparagine; the CPP sequence YGRKKRRQRRR on the HIV-1 peptide is coupled with superoxide dismutase to give it the ability to transmembrane; the CPP sequence is a Trans-activating transcriptional activator sequence. The beneficial effects of the present invention are as follows: (1) The key raw material superoxide dismutase used in the present invention is essentially a protein, which is highly safe and has no side effects on the human body; (2) The product of the present invention has an excellent use effect, Stubborn psoriasis can be cured after spraying for about half a month; (3) Compared with expensive medicines for treating psoriasis, the product of the present invention has low cost.

Description

technical field [0001] The invention belongs to the technical field of application of enzyme preparations, and in particular relates to the application of superoxide dismutase in the preparation of medicines for treating psoriasis, and also relates to the above-mentioned application method. Background technique [0002] Psoriasis (psoriasis) is a chronic, refractory and easily relapsed immune skin disease. It is hereditary. It is mainly manifested as skin erythema and plaques, covered with silvery white scales. Sites include the trunk, extremities, and scalp. At present, there is no medicine that can cure the disease, only by effectively controlling the development of the disease and alleviating the disease. [0003] Commonly used drugs in clinical practice include: [0004] Tars, anthralin, corticosteroids; methotrexate, hydroxyurea, ethyleneimine, ethimorph; [0005] In recent years, acitretin, which has been widely used in patients with psoriasis, has relatively large ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/44A61K9/08A61K47/10A61K47/36A61K47/42A61P17/06
CPCA61K38/446A61K9/0014A61K9/08A61K47/36A61K47/42A61K47/10C12Y115/01001A61P17/06
Inventor 夏勇
Owner 广州研展科技有限公司
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