Micro-swelling type biocompatible membrane and preparation method thereof

Abstract

The invention relates to a biocompatible membrane and particularly relates to a micro-swelling type biocompatible membrane and a preparation method thereof. The preparation method of the micro-swelling type biocompatible membrane comprises the following steps of synthesizing a copolymer containing a skeleton and a hydrophilic group; introduction of a biocompatibility function; preparation of a biocompatibility film solution; and coating of a biocompatibility film. According to the method, glucose can be effectively regulated and controlled, and high biocompatibility (service life) is realized, so sensitivity, accuracy, reproducibility, stability, specificity and the anti-interference capability of dynamic detection of the glucose biosensor are improved, the service life of a dynamic glucometer is prolonged, and cost of the glucose biosensor is greatly reduced.

Description

technical field [0001] The invention relates to a biocompatible film, in particular to a micro-swellable biocompatible film and a preparation method thereof. Background technique [0002] The continuous blood glucose meter developed rapidly in recent years has brought good news to diabetic patients. Continuous blood glucose meter allows diabetic patients to regulate blood sugar more conveniently and effectively. It can continuously detect blood sugar in real time, and has gradually become a powerful tool for blood sugar regulation. As the main component of the biosensor of the continuous blood glucose meter and the only interface directly in contact with the living body, the performance of the biocompatible film directly determines the performance and working life of the continuous blood glucose meter. The existing continuous blood glucose meters are all developed based on the first or second generation biosensing technology. Dekang’s Dexcom G5 and G6 and Medtronic’s Guar...

AI Technical Summary

Problems solved by technology

Too thick a biocompatible film will directly cause the continuous blood glucose meter to respond to glucose for too long, causing serious hysteresis and greatly reducing its accuracy

More importantly, one of the main properties of hydrogel is that it swells to a considerable extent in the aqueous phase. Excessive swelling will greatly increase the volume of the sensor and weaken the mechanical strength and adhesive properties of the biocompatible film (USA Patent US 9668685), may cause when the sensor is taken out, part of the biocompatible film is torn and left in the body

In addition, there is a chemical cross-linking reaction in the existing hydrogel-based biocompatible film formulation, which greatly shortens the service life of the biocompatible film solution and virtually increases the lifespan of the dynamic blood glucose meter. Production cost (US patents US 9777307, US9042954)

What's more serious is that with the increase of use time, more and more chemical cross-linking reactions will occur, and the viscosity of the biocompatible film solution will also increase, which will seriously affect the consistency of the product.

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