Method for measuring intracranial blood vessel flow reserve parameters by using ultrasonic microbubbles

Abstract

The invention provides a method for measuring intracranial blood vessel flow reserve parameters by using ultrasonic microbubbles. The method comprises the following steps of: firstly, sending ultrasonic waves to a target blood vessel and a simulated blood vessel so as to determine the optimal pressure measurement incident sound pressure at the far end and the near end of blood vessel stenosis; determining amplitude compensation factors of the stenosis far end and the stenosis near end of the simulated blood vessel according to a relation curve between the sub-harmonic amplitude of the stenosis far end and the stenosis near end of the target blood vessel and the stenosis near end of the simulated blood vessel and the incident sound pressure, and correcting the blood pressure of the simulated blood vessel and a microbubble sub-harmonic amplitude conversion formula by using the amplitude compensation factors; and establishing a conversion relation expression between near-end blood pressure of a target blood vessel stenosis and far-end blood pressure and microbubble subharmonic amplitudes, obtaining the microbubble sub-harmonic amplitudes of the stenosis of the target blood vessel at the far end and the near end under the optimal pressure measurement incident sound pressure, and combining a conversion formula to obtain a blood vessel flow reserve value of the target blood vessel. The measurement method is non-invasive measurement. The blood pressure values of the near end and the far end of the narrow section can be obtained without invasive puncture, and the secondary injury risk during monitoring is greatly reduced.

Description

technical field [0001] The invention relates to the technical field of medical diagnosis, in particular to a method for measuring blood flow reserve parameters of intracranial blood vessels by using ultrasonic microbubbles. Background technique [0002] Intracranial atherosclerotic stenosis (ICAS) is the most common vascular lesion in stroke patients. At present, the clinical criterion for judging whether to implant stents or other active interventions for stenotic lesions is the severity of stenosis in the sense of lumen anatomy. Generally patients with a stenosis rate of less than 70% are considered moderate stenosis and low risk. However, recent studies have found that more than 40% of stroke recurrences occur in patients with 50-69% stenosis. This is because in addition to anatomical stenosis, collateral circulation, plaque morphology, and downstream vascular flow resistance will also highly affect blood perfusion. Importantly, in the cardiovascular field, the blood fl...

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Problems solved by technology

[0005] Aiming at the problems existing in the prior art, the present invention provides a method for measuring intracranial blood flow reserve parameters by using ultrasonic microbubbles. On the basis of the SHAPE method, by introducing adaptive incident sound pressure correction and subharmonic amplitude The compensation factor is used to solve the problem of ultrasonic transcranial attenuation, so that the blood pressure at the proximal end and distal end of vascular stenosis can be measured simultaneously and in real time, and finally obtain the real-time FF value of intracranial blood vessels

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