1152 results about "BP - Blood pressure" patented technology

The invention provides a system for continuously monitoring a patient during hemodialysis. The system includes a hemodialysis machine for performing the hemodialysis process that features a controller, a pump, a dialyzer filter, a lumen, and an interface to a body-worn monitor. A patient attaches to the dialysis machine through the lumen, and wears a body-worn monitor for continuously measuring blood pressure. The monitor includes an optical system for measuring an optical waveform, an electrical system for measuring an electrical waveform, and a processing component for determining a transit time between the optical and electrical waveforms and then calculating a blood pressure value from the transit time. The body-worn monitor features an interface (e.g. a wired serial interface, or a wireless interface) to transmit the blood pressure value to the controller within the hemodialysis machine. The controller is configured to receive the blood pressure value, analyze it, and in response adjust the dialysis process.

Systems and methods for assessing a physiological parameter of a target tissue wherein a pulse of focused ultrasound is applied to a target tissue site thereby inducing oscillation of the target tissue. By these systems and methods, a property of an acoustic signal emitted from the oscillating target tissue is measured and related to a physiological property of the tissue. Specific applications for systems and methods of the present invention include the assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties.

A fluid delivery device is provided for delivering fluid to a target site such as an intervertebral disc during discography. The fluid delivery device includes pressure and volume sensors to determine the pressure and the volume of the fluid delivered to the intervertebral disc. The fluid delivery device is hand-held during use and includes a syringe assembly having a plunger with threads that enables controlled discharge of the fluid from the fluid delivery device by rotating the plunger in a housing of the fluid delivery device. The fluid delivery device may also include a communication module to wirelessly transfer data to an external device outside of a sterile field, while the fluid delivery device is in the sterile field. The fluid delivery device may also include a physiological sensor to monitor involuntary pain responses based on changing physiological parameters such as increases in body temperature or blood pressure.

The invention provides a system for continuously monitoring a patient during hemodialysis. The system includes a hemodialysis machine for performing the hemodialysis process that features a controller, a pump, a dialyzer filter, a lumen, and an interface to a body-worn monitor. A patient attaches to the dialysis machine through the lumen, and wears a body-worn monitor for continuously measuring blood pressure. The monitor includes an optical system for measuring an optical waveform, an electrical system for measuring an electrical waveform, and a processing component for determining a transit time between the optical and electrical waveforms and then calculating a blood pressure value from the transit time. The body-worn monitor features an interface (e.g. a wired serial interface, or a wireless interface) to transmit the blood pressure value to the controller within the hemodialysis machine. The controller is configured to receive the blood pressure value, analyze it, and in response adjust the dialysis process.

An arterial blood pressure apparatus and methods for using the apparatus are disclosed. The apparatus has a force transfer element for applying unidirectional force to a body part of the subject and a pressure sensor for generating a signal based on the unidirectional force. Multiple degrees of force may be applied simultaneously or serially. The apparatus also has a second sensor for generating a signal associated with blood volume within a blood vessel of the body part and a processor for inferring arterial blood pressure from the force sensor signal and the second sensor. The apparatus may take the form of a glove or a wand.

The present invention relates to a device for determining a characteristic point in the cardiac cycle that comprises means for calculating the curve of the blood flow rate D(t) in the aorta from the curve of the arterial blood pressure signal P(t) and determining from the curve of the blood flow rate D(t) in each cardiac cycle the time at which an incisura point lies. The device can be used for activating an intra-aortal balloon pump (IABP).

A sensor assembly used for the measurement of one or more physiologic parameters of a living subject which is capable of storing both data obtained dynamically during use as well as that programmed into the device. In one embodiment, the sensor assembly comprises a disposable combined pressure and ultrasonic transducer incorporating an electrically erasable programmable read-only memory (EEPROM), the assembly being used for the non-invasive measurement of arterial blood pressure. The sensor EEPROM has a variety of information relating to the manufacture, run time, calibration, and operation of the sensor, as well as application specific data such as patient or health care facility identification. Portions of the data are encrypted to prevent tampering. In a second embodiment, one or more additional storage devices (EEPROMs) are included within the host system to permit the storage of data relating to the system and a variety of different sensors used therewith. In a third embodiment, one or more of the individual transducer elements within the assembly are made separable and disposable, thereby allowing for the replacement of certain selected components which may degrade or become contaminated. Methods for calibrating and operating the disposable sensor assembly in conjunction with its host system are also disclosed.

A method and system for use in measuring the endothelial dysfunction utilizing flow mediated dilation and determining arterial health of a patient. The system includes a non-invasive blood pressure monitor, an ultrasound system and a pulse oximeter monitor that all communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer, blood pressure cuff and pulse oximeter sensor are positioned on an arm of the patient. The blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining a parameter of the artery, such as diameter, and the flow rate of blood through the artery without any operator intervention. At the same time, the pulse wave velocity PWV is calculated between the ultrasound transducer and the finger probe of the pulse oximeter following the occlusion period. Based upon the detected characteristics of the artery before and after occlusion, as well as the PWV, the system can determine the endothelial dysfunction and arterial health of the patient.

The invention relates to a cardiovascular healthcare management system which as an infomediary site with databases having information relating to cardiovascular disease risk factors such as age, blood pressure, LDL, HDL and subfractions thereof and cardiovascular disease management such as diet, exercise, drugs and cardiovascular educational materials. The physician can communicate electronically with the infomediary site to obtain patient test results and formulate a patient treatment plan from the diet, exercise and drug data. The physician can electronically communicate treatment plans to the patient through a record in the infomediary site. The patient can electronically communicate compliance information to the physician through the patient record. The infomediary site may also provide a case manager to provide initial draft treatment plans to the physician, gather patient history data and / or patient treatment plan compliance data.

A blood pressure measurement system that utilizes a non-invasive blood pressure (NIBP) monitor having a blood pressure cuff and pressure transducer. The measurement system provides a plurality of separate processing techniques that each receive a plurality of oscillometric data values from the pressure transducer. Each of the processing techniques separately constructs an oscillometric envelope based upon the oscillometric data values. Based upon the plurality of separate oscillometric envelopes, the system compares the envelopes and develops a calculated blood pressure from the plurality of envelopes. The calculated blood pressure is then displayed by the NIBP system. The plurality of oscillometric envelopes can be compared and combined in different manners to calculate the patient's blood pressure from the plurality of different processing techniques.

An apparatus (100), control system (150) and methods are provided for directly measuring a pressure gradient, i.e. by real-time pressure measurements, with particular application for in situ measurement of transvalvular blood pressure gradients for the aortic valve and other heart valves, using minimally-invasive techniques. The apparatus takes the form of a multi-sensor assembly, e.g. enclosed within a micro-catheter or a steerable guidewire, and comprises a plurality of optical pressure sensors (10) is arranged along a length of the distal end portion (101), for measuring pressure simultaneously at each sensor location. For example, four MOMS optical pressure sensors (10), and optionally, a flow sensor (20), are incorporated into a distal end portion (101) having a diameter of 0.89 mm or less, and preferably 0.46 mm or less. Beneficially, all sensors are optically coupled, via respective optical fibers (11), to an optical coupler (112) at the proximal end of the multi-sensor apparatus, without requiring electrical connections.

Methods for adaptive cuff inflation for the purposes of occluding a limb of a subject include inflating a cuff to a pressure at or above limb occlusion pressure and periodically deflating the cuff to detect amplitude of oscillometric oscillations reaching or exceeding a predetermined threshold, whereby indicating that the cuff pressure has reached an updated systolic blood pressure. Selecting the cuff to be wide enough to define limb occlusion pressure at or below the systolic blood pressure assures that this maneuver does not compromise cessation of blood flow to the limb. Devices are disclosed configured to operate in at least two of the following three operating modes: a tourniquet mode, a remote conditioning mode and a blood pressure monitoring mode.

The invention discloses an organism-falling detection device and method. The device comprises a falling motoring unit, a blood-pressure monitoring unit, a body temperature monitoring unit and a micro-processing unit, wherein the falling motoring unit is used for collecting the acceleration information of an organism; the blood-pressure monitoring unit is used for collecting the blood pressure and / or pulse information of the organism; the body temperature monitoring unit is used for collecting and processing the body temperature information of the organism; and the micro-processing unit is used for controlling the falling motoring unit to start and receive the acceleration information of the organism, analyzing and judging the acceleration information, starting the blood-pressure monitoring unit and the body temperature monitoring unit according to a judged result, detecting and analyzing the blood pressure and / or pulse information and the body temperature information of the organism, and generating falling alarm information or disease alarm information according to a processed result. According to the device and the method, the type of falling can be accurately and effectively judged.

Adaptive attachments used in combination with a blood pressure cuff enable various blood pressure measurements to be taken in a hospital or other setting having various single and / or dual lumen manual or electronic blood pressure measuring equipment with a single, patient-worn cuff.

A synthetic venous valve and graft combination that exerts no radial force at the valve site is disclosed. The trilobed valve (11) is passively actuated by venous blood pressure changes. When open, the aperture for blood flow is approximately that of the original vein. The prosthesis is useful for replacing nonfunctioning venous valves in the human vasculature.

Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are antagonists of the adrenergic receptor α2A. The compounds may also bind to and are an antagonist of the adrenergic receptor α2B; or the compounds are not antagonists of the adrenergic receptor α2B and the compounds are administered in conjunction with a second agent that reduces, or is expected to reduce, blood pressure in an individual. The compounds may find use in therapy, e.g., to regulate blood glucose level, increase insulin secretion and treat diseases or conditions that are, or are expected to be, responsive to an increase in insulin production. Use of the compounds to treat type 2 diabetes is particularly described.

A method and device for measuring the blood pressure of artery and its personalized correction technique are disclosed. A series of the pressure values (P) for sleeve band and the time delay values (Tk) of the relative remote Ke's sounds are obtained. The function relation Tk(P) between said pressure change and sound delay is in turn obtained. Measuring a Tk relative to a P can calculate out the blood pressure change. A regression equation for continuous measurements of arteral blood pressure is used to obtain a personalized correction coefficient.

The invention relates to an individualized correction method and a device used for continuous measurement and estimation of arterial blood pressure by pulse wave. The PWTT (Pulse Wave Translation Time) of a measured person is recorded in real time, the mean blood pressure BP1 is acquired and recorded, the PWTT1 at the corresponding time is obtained, and the two data are taken as a first set of data. Then, the PWTT of the measured person is continuously monitored and recorded and at each time of monitoring that the absolute value of a difference between the present PWTT value and the PWTT value in the set of data recorded previously is larger than a domain value, an oscillography blood pressure instrument is triggered to measure the present mean blood pressure value BPn of the measured person. In this way, two or more sets of PWTT values and corresponding mean BP values are sequentially acquired in a monitoring time section, and two or more sets of data are taken as calculating data to calculate the individualized regression coefficients a and b of an equation A. The method and the device are easy in operation and implementation, and can enable the calculated regression coefficients to more agree with the actual conditions of measured individuals.

An information management, analysis and response generation system is used with monitoring devices for the remote testing and monitoring of system users' physiological information (e.g. diabetes testing, blood pressure testing, anti-coagulation, etc.). The information management, analysis and response generation system allows testing and monitoring devices manufactured by third party companies to communicate with the system through existing communication networks means enabled by proprietary technology. Upon analysis of the collected data, the system is capable of initiating communications with third parties, including interactive clinical alert notifications.

A method may include controlling a ventilator to introduce mean airway pressure (MAP) variations in a patient to induce slow waves of substantially fixed amplitude and period to the patient. The method may also include analyzing arterial blood pressure in the patient with respect to the MAP variations and determining, based on the analyzing, whether an autoregulatory mechanism associated with the patient's brain is operating properly.

Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor α2B antagonists. The compounds may also bind to and antagonize adrenergic receptor α2B. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and / or (ii) promote renal blood flow and / or (iii) decrease or inhibit sodium reabsorption. The compounds may also be used to treat diseases or conditions that are, or are expected to be, responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular and renal disorders is particularly described.

Adaptive attachments used in combination with a blood pressure cuff enable various blood pressure measurements to be taken in a hospital or other setting having various single and / or dual lumen manual or electronic blood pressure measuring equipment with a single patient-worn cuff.

One embodiment of a seat belt attachment (3) for providing, recording and wireless transmission of electrode (6,7,8,9) sensor autonomic physiologic data as well as distance vector locator (10) which communicates at both ends with flexible attachment fasteners (1, 2) to the seat belt. The outer covering of the attachment is made of a flexible material, Velcro secured and folded such that it can easily move slidably without fracturing, along its axes. In addition, an outer layer of cloth is added for ease of sweat stain absorption. The longitudinal axis of the base contains two through holes or portals (11, 12) for blood pressure cuff (14) attachment and wireless transmission of data respectively. Other embodiments are described and shown.

The present invention provides a new multi-mode sphygmomanometer which integrates into one enclosure a full manual sphygmomanometer comprising a mechanical cuff pressure measuring and display system, a manual inflation bulb and deflation valve such elements comprising the manual / mechanical aspect of the integrated device. Within the same physical enclosure and integrated with the manual sphygmomanometer the device also comprises an electronic blood pressure measuring and monitoring device comprising electronic sensing of the pressure, electronic indication of the cuff pressure and oscillation or KS amplitudes and logic implemented in a microprocessor that automatically interprets these signals to determine the BP parameters.

The invention relates to health-preserving fungal tea and application thereof. The health-preserving fungal tea is prepared from the raw materials by weight fraction: 10 to 50 percent of edible or medicinal fungal fruit body and 50 to 90 percent of tea. The invention provides health-preserving fungal tea with simple and scientific matching and application thereof in anticancer aspect, so that the nutritive value and pharmacological action of single product are greatly improved. Through scientific matching, the actions of the active substances of the edible or medicinal fungal fruit body and tea are multiplied, so that the nutritive value and pharmacological action are greatly improved. By scientific matching, the fungal tea has unique mouthfeel and flavor, can serve as tea or tea bag to be directly soaked for drinking, can also be prepared into fungal tea beverage, oral liquid, polysaccharide capsule, tablets and the like, and has the efficacies of conditioning yin-yang balance of the functions of five internal organs, improving organism immunity, improving fatigue state, conditioning endocrine dyscrasia, improving blood pressure, blood sugar and blood fat, strengthening body, expelling toxin and protecting liver, preventing disease and radiation, reducing weight and fat, resisting tumor and aging and the like.

This invention relates to modified Vasoactive Intestinal Peptide (VIP) / Pituitary Adenylate Cyclase Activating Peptide (PACAP) Receptor 2 (VPAC2) agonists (VPAC2 agonists) comprising a VPAC2 agonist linked to a polyethylene glycol polymer, as well as related formulations, dosages, and methods of administration thereof for therapeutic purposes. These VPAC2 agonists, compositions, and methods are useful in providing a treatment option for those individuals afflicted with a metabolic disorder such as diabetes, impaired glucose tolerance, metabolic syndrome, or prediabetic states, by inducing glucose-dependent insulin secretion in the absence of the therapeutically limiting side effect of reducing or lowering blood pressure.

A sphygmomanometer separately includes a cuff accommodating an air bladder and a main body provided with an expanding / contracting mechanism arranged to expand and contract the air bladder, and the cuff includes a tubular cuff main body portion into which an upper arm is insertable and a gripping portion provided on an outer peripheral surface of the cuff main body portion. The cuff main body portion has a tightening belt wrapped around the outer side of the air bladder and a tightening length adjustment mechanism arranged to variably adjust a tightening length of the tightening belt over the upper arm. The tightening length adjustment mechanism includes a winding roller arranged to wind and feed the tightening belt, a geared motor arranged to drive and rotate the winding roller, and an electromagnetic brake arranged to apply a braking force to the winding roller. With such a configuration, in the sphygmomanometer in which the cuff and the main body are separated from each other, the cuff can be easily attached to a measurement site, and reliable winding of the cuff around the measurement site can be repeated in every measurement.

Methods and devices for long term, cuffless, and continuous arterial blood pressure estimation using an end-to-end deep learning approach are provided. A deep learning system comprises three modules: a deep convolutional neural network (CNN) module for learning powerful features; a one- or multi-layer recurrent neural network (RNN) module for modeling the temporal dependencies in blood pressure dynamics; and a mixture density network (MDN) module for predicting final blood pressure value. This system takes raw physiological signals, such as photoplethysmogram and / or electrocardiography signals, as inputs and yields arterial blood pressure readings in real time.