Alltrenogest sustained-release injection and preparation method and application thereof
A technology for allyrogestin and injection, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and medical preparations without active ingredients, etc. Sexual issues, etc.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0021] Embodiment 1: the preparation of allyl progesterone injection
[0022] An allylgestrine injection, the preparation method of which comprises: weighing dimethyl sulfoxide and sucrose acetate isobutyrate, and mixing them at a mass ratio of 4:1 at 27°C to obtain a clear, precipitate-free, transparent solvents such as figure 1 As shown, then add allylgestrine, the preparation obtains the allylgestrine content that is 160mg / mL clarification does not have the allylgestrine injection of precipitation, as figure 2 shown.
Embodiment 2
[0023] Embodiment 2: the mensuration of release degree in vitro
[0024] (1) First prepare 0.01mol / L PBS buffer solution of pH7.4, mix 1.6gNaCl, 0.04g KH 2 PO 4 , 0.58gNa 2 HPO 4 , 0.04g KCl was added to the beaker, dissolved with a certain amount of distilled water, then transferred to a 200mL volumetric flask for constant volume, and finally the pH of the solution was adjusted to 7.4 with HCl.
[0025] Take 5mL of absolute ethanol into a 10mL volumetric flask, and then dilute with PBS buffer to prepare 50% ethanol PBS buffer.
[0026] (2) Three parts (injections 1, 2, 3) of the allylgestrine injection in Example 1 (the content of allylgestrine is 160 mg / mL), one part without allylgestrine and only dimethyl The blank injection of sulfoxide and sucrose acetate isobutyrate (dimethyl sulfoxide and sucrose acetate isobutyrate were mixed at a mass ratio of 4:1 at 27°C to obtain a clear solution without precipitation, transparent solvent), a part of dimethyl sulfoxide solution...
Embodiment 3
[0035] Embodiment 3: the mensuration of recovery rate and stability
[0036] (1) Preparation of standard curve
[0037] Prepare a solution of allylregestin absolute ethanol with a concentration of 1 mg / mL as the mother liquor, and dilute the mother liquor into 100 μg / mL, 80 μg / mL, 60 μg / mL, 40 μg / mL and 20 μg / mL of allylregestin absolute ethanol standard solution. Using absolute ethanol as a blank, measure the absorbance of the standard solution of each concentration respectively, and record it well, and make a standard curve. The results are as follows: Figure 4 As shown, the correlation coefficient r 2 >0.99, good linear performance.
[0038] (2) determination of content, recovery and stability
[0039] Get 4 samples of allylgestrine sustained-release injection in Example 1 (corresponding to 0-3), be mixed with dehydrated alcohol into 20, 40, 80 μ g / mL allylgestrine solution, measured content, recovery The rates and coefficients of variation are shown in Table 2. It can...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com