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A kind of EGCG combination drug and its medical use

A technology of combined drug use and application, applied in pharmaceutical formulations, drug combinations, anti-tumor drugs, etc., can solve problems such as serious complications and limited application of patients' eating resistance, achieve low toxic and side effects, improve eating resistance, reduce eating resistance, etc. The effect of small tumor volume

Active Publication Date: 2022-03-22
AFFILIATED CANCER HOSPITAL OF SHANDONG FIRST MEDICAL UNIV SHANDONG CANCER INST (SHANDONG CANCER HOSPITAL)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main methods for relieving feeding blockage include: surgical resection of the tumor and replacement of the esophagus with the stomach, esophageal stent or nutrition tube implantation, radiotherapy, chemotherapy drugs, traditional Chinese medicine, etc., but none of the above methods can relieve the patient’s feeding blockage in the short term sense and often have application limitations and the possibility of serious complications

Method used

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  • A kind of EGCG combination drug and its medical use
  • A kind of EGCG combination drug and its medical use
  • A kind of EGCG combination drug and its medical use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 EGCG suspension

[0026] Step A, adding 100 mg of EGCG, 0.2 g of ascorbic acid, 0.6 g of glycyrrhizic acid, and 0.5 g of sodium chloride into a 38 g / L aqueous solution of sodium carboxymethyl cellulose as a dispersed phase;

[0027] In step B, the dispersed phase obtained in step A is added to an ethanol solution containing 25g / L ethyl cellulose, stirred, and after the ethanol volatilizes, dry to obtain EGCG sustained-release microspheres;

[0028] In step C, the slow-release microspheres obtained in step B are prepared into a suspension according to a conventional process.

Embodiment 2

[0029] Embodiment 2 EGCG suspension

[0030] Step A, adding 100 mg of EGCG, 0.1 g of ascorbic acid, 0.5 g of glycyrrhizic acid, and 0.5 g of sodium chloride into a 38 g / L aqueous solution of sodium carboxymethyl cellulose as a dispersed phase;

[0031] In step B, the dispersed phase obtained in step A is added to an ethanol solution containing 25g / L ethyl cellulose, stirred, and after the ethanol volatilizes, dry to obtain EGCG sustained-release microspheres;

[0032] In step C, the slow-release microspheres obtained in step B are prepared into a suspension according to a conventional process.

Embodiment 3

[0033] Embodiment 3 EGCG suspension

[0034] Step A, adding 100 mg of EGCG, 0.4 g of ascorbic acid, 0.2 g of glycyrrhizic acid, and 0.5 g of sodium chloride into a 38 g / L aqueous solution of sodium carboxymethyl cellulose as a dispersed phase;

[0035] In step B, the dispersed phase obtained in step A is added to an ethanol solution containing 25g / L ethyl cellulose, stirred, and after the ethanol volatilizes, dry to obtain EGCG sustained-release microspheres;

[0036] In step C, the slow-release microspheres obtained in step B are prepared into a suspension according to a conventional process.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a medical application of EGCG monomer or compound, mainly for the preparation of EGCG monomer or the compound of EGCG and organic acid and / or sodium chloride in the treatment of esophageal cancer and the treatment of esophageal cancer. The use in the medicine of eating block sensation. The EGCG monomer or compound provided by the present invention can effectively treat or improve the patient’s sense of resistance to eating caused by esophageal squamous cell carcinoma, and the effective rate of treatment can reach more than 84%. The grade of esophageal pain decreased significantly, and the side effects were low.

Description

technical field [0001] The invention relates to a combined drug of EGCG and its medical use, in particular to the use of combined drug of EGCG and organic acid and / or sodium chloride in the preparation of drugs for treating esophageal obstruction related to esophageal cancer, which belongs to the technical field of traditional Chinese medicine. Background technique [0002] Esophageal cancer is the sixth leading cancer-related death in the world; in 2020, there will be more than 600,000 new cases of esophageal cancer and about 550,000 deaths worldwide. Esophageal cancer is a rapidly progressive and fatal disease, with two-thirds of patients diagnosed with advanced or metastatic disease. The median survival of esophageal cancer is about 8 to 10 months, and the five-year survival rate is less than 5%. [0003] Esophageal cancer is also a high-incidence malignant tumor in my country, ranking sixth and fourth in morbidity and mortality, respectively. The early symptoms of esop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61K31/375A61K31/704A61K33/14A61K31/192A61K31/19A61K31/60A61K9/10A61K47/38A61P35/00A61P1/00
CPCA61K31/353A61K31/375A61K31/704A61K33/14A61K31/192A61K31/19A61K31/60A61K9/10A61K47/38A61P35/00A61P1/00A61K2300/00
Inventor 赵汉玺贾丽朱婉琦邢力刚谢鹏李晓琳孟祥姣
Owner AFFILIATED CANCER HOSPITAL OF SHANDONG FIRST MEDICAL UNIV SHANDONG CANCER INST (SHANDONG CANCER HOSPITAL)
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