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Functionalized porous composite material for hemostasis and application thereof

A porous composite material and functionalized technology, applied in the field of functionalized porous composite materials, can solve the problems of unsatisfactory hemostasis effect of massive hemorrhage, harsh use conditions, and single function.

Inactive Publication Date: 2021-09-10
NANJING VOCATIONAL UNIV OF IND TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many problems in the existing hemostatic materials for hemorrhage: biological hemostatic materials have poor stability when used alone, and the use conditions are harsh; polysaccharide hemostatic materials lack mechanical strength and are only suitable for low and moderate bleeding, and the hemostatic effect on hemorrhage is not ideal ; For deep, narrow or irregular bleeding wounds such as blast wounds, firearm wounds, or penetrating trunk wounds, they lack the ability to adapt to the shape and quickly seal the wound
In addition, the existing wound repair materials have a single function, and most of them lack inherent antibacterial properties, and the repair effect on deep, hyperoozing or chronic wounds is not ideal

Method used

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  • Functionalized porous composite material for hemostasis and application thereof
  • Functionalized porous composite material for hemostasis and application thereof
  • Functionalized porous composite material for hemostasis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0026] (1) Polyvinyl alcohol (referred to as PVA) particles are dissolved in deionized water to obtain a uniformly dissolved PVA aqueous solution, and a cross-linking agent TAIC is added to obtain a photocurable solution.

[0027] (2) Generated by Materialize 3-maitc software figure 1 In the porous structure model shown, the porosity is controlled by controlling the diameter of the rod, and the solution is cured by using an SLA photo-curing 3D printer to obtain figure 1 The gradient porous structure is shown.

[0028] (3) Thrombin powder is dissolved in phosphate buffered saline solution, obtains thrombin solution (300UmL -1 , U is the unit of thrombin activity), then the porous material was immersed in the solution for 1 h, and after taking it out, it was placed in a constant temperature and humidity chamber at 40°C for 3 h, so that the porous material could fully interact with the thrombin solution. Subsequently, the material was taken out and placed in 80% ethanol solutio...

experiment example

[0030] (1) Chemical structure characterization

[0031] Characterization of the Molecular Structure of Porous Composite Materials by Fourier Transform Infrared Spectroscopy. Divide the material sample into a cube of 10mm×10mm×10mm, test the infrared curve of each sample with an infrared spectrometer, and analyze its characteristic functional groups. The infrared spectrum resolution of the test process is 4cm -1 , the number of scans is 32, and the wavenumber range is 2000cm -1 ~800cm -1 .

[0032] The result is as figure 2 As shown, due to the N-H stretching vibration, there are two possibilities of symmetry and asymmetry, at 3500~2800cm -1 There are two absorption peaks at 1730cm -1 There is a strong peak at 1230~1260cm -1 The place is the characteristic peak of the symmetric and antisymmetric stretching vibration of C-O, 1625cm -1 is the characteristic peak of C=O in COOH.

[0033] (2) Mechanical performance test

[0034] During the structural testing, the FR-1001...

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Abstract

The invention discloses a functionalized porous composite material for hemostasis and application thereof, and the functionalized porous composite material is mainly prepared by the following steps: (1) preparing a polyvinyl alcohol aqueous solution, and adding a cross-linking agent to obtain a photocurable solution; (2) generating a porous structure model through software, the porosity of the porous structure changes linearly, the solution obtained in the step (1) is subjected to light curing through 3D printing, and a material with the porous structure shown by the model is obtained; and (3) immersing the material obtained in the step (2) into a thrombin solution, taking out the material, placing the material in a constant-temperature and constant-humidity condition for full action, taking out the material, cleaning, and drying to obtain the functionalized porous composite material. Compared with the prior art, the functionalized porous composite material has the advantages that multiple hemostasis modes such as physical adsorption, biological stimulation and mechanical plugging are achieved through the gradient porous material, and the problems that an existing hemostasis material is insufficient in mechanical strength, single in hemostasis mode, low in hemostasis effect and the like are solved.

Description

technical field [0001] The invention belongs to the technical field of hemostatic materials, and in particular relates to a functionalized porous composite material for hemostasis and its application. Background technique [0002] Rapid hemostasis of hemorrhage and wound care and repair in battlefields, accidents or disasters are two important issues in trauma treatment. The study of new and efficient bleeding hemostatic materials and wound repair materials is of great significance for treating the wounded and saving lives. There are many problems in the existing hemostatic materials for hemorrhage: biological hemostatic materials have poor stability when used alone, and the use conditions are harsh; polysaccharide hemostatic materials lack mechanical strength and are only suitable for low and moderate bleeding, and the hemostatic effect on hemorrhage is not ideal ; For deep, narrow or irregular bleeding wounds such as blast wounds, firearm wounds or penetrating trunk wound...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/04A61L24/00
CPCA61L24/0036A61L24/0094A61L24/108A61L24/0015A61L2300/254C08L29/04
Inventor 成诚
Owner NANJING VOCATIONAL UNIV OF IND TECH
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