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Eye drops rich in animal and plant active ingredients and preparation method

A technology of active ingredients and eye drops, applied in the field of medicine, can solve the problems that macromolecular drugs are difficult to penetrate the eye, eye tissue immune damage, high treatment risk, etc., so as to nourish the optic nervous system and optic nerve cells, give The drug process is simple and convenient, and the effect of reducing the cost of treatment

Pending Publication Date: 2021-09-17
李宇宙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present clinically for this kind of disease, mainly adopt systemic drug administration, vitreous cavity injection or surgical implantation etc. drug administration methods, just can make the active ingredient in the medicine act on fundus position, cause very big misery to the patient in clinic, still need High costs and high treatment risks
However, due to the existence of the blood-ocular barrier, it is difficult for macromolecular drugs to penetrate all layers of ocular tissues and achieve sufficient drug concentration in the eye, and exogenous macromolecular drugs are likely to cause immune damage to ocular tissues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A rich source of animals and plants of the active ingredient of eye drops, wherein the parts comprising the following components by weight: 0.1 parts active polypeptide, 5 parts of herbal extracts, 0.1 parts of lubricating moisturizing enhancer, 0.1 parts of a preservative, a tonicity adjusting agent 1 parts, insulin 0.5mg / mL, the balance made up with saline, pH 6.0.

[0052] The active polypeptide is obtained by the following extraction processes:

[0053] (1) Take a healthy and fresh animal-rich polypeptide animal tissue, tissue liquid or body fluid, debris, cleaning, chopping, tissue mask;

[0054] (2) sodium chloride solution was added an equal mass mixed, colloid milled homogenate was like;

[0055] (3) Add 1 by mass sodium chloride solution and the like mixed, 1% by weight of the starting material proteases (including trypsin, papain, an enzyme complex), the water bath was heated to 50 ℃, the pH adjusted with saturated calcium hydroxide to 7.5 , under constant stirr...

Embodiment 2

[0076] A rich source of plant and animal eye drops the active ingredient, comprising the following parts by weight of component: 5 parts active polypeptide, 15 parts of herbal extracts, moisturizing lubricity enhancers 5 parts, 0.5 parts of a preservative, 5 parts of tonicity adjusting agent, I an amount to make up with saline, pH 8.0.

[0077] The active polypeptide is obtained by the following extraction processes:

[0078] (1) Take a healthy and fresh animal-rich polypeptide animal tissue, tissue liquid or body fluid, debris, cleaning, chopping, tissue mask;

[0079] (2) sodium chloride solution was added an equal mass mixed, colloid milled homogenate was like;

[0080] (3) Add sodium chloride solution three times the mass of the like mixing, adding 2 wt% of the starting protease (including papain, an enzyme complex), the water bath was heated to 55 ℃, saturated with calcium hydroxide adjusted to pH 8.5, constant stirring under hydrolysis 15H;

[0081] (4) placed in a 10 deg.] ...

Embodiment 3

[0101] An eye medium rich in an active ingredient, including the following weight component: 3 parts of the active polypeptide, 10 Chinese medicine extracts, 3 parts of the lubricant moisturizer, 0.3 preservatives, 3 osmotic regulators, The quantity uses physiological saline to make up, pH is 7.0.

[0102] The active polypeptide is obtained by the following extraction processes:

[0103] (1) Take a healthy and fresh animal-rich polypeptide animal tissue, tissue liquid or body fluid, debris, cleaning, chopping, tissue mask;

[0104] (2) Add such weight sodium chloride solution to mix, colloidal grinding is homogenous;

[0105] (3) The addition of 2 times and other sodium chloride solutions are mixed, adding the amount of 1.5% of the weight of the raw material to 52 ° C, the water bath is heated to 52 ° C, and the pH is adjusted to 8.0 with saturated calcium hydroxide to 8.0, stirring at a constant speed, hydrolyzing 12h;

[0106] (4) Placing at 0 ° C for 4 hours, the precipitation ...

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PUM

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Abstract

The invention provides eye drops rich in animal and plant active ingredients. The eye drops comprise 0.1-5 parts of active small molecule polypeptide, 5-15 parts of traditional Chinese medicine extract, 0.1-5 parts of lubrication moisturizing enhancer, 0.1-0.5 part of preservative, 1-5 parts of osmotic pressure regulator and the balance of normal saline, and the pH is 6.0-8.0. The preparation process adopts various modern biological high-tech integrated technologies, effective ingredients and active substances in traditional Chinese medicines and animal tissues are retained to the greatest extent, the active substances have a synergistic effect, and the eye nerve cell nutrition can be supplemented; and the molecular weight of the extracted traditional Chinese medicine extract and active small molecule polypeptide is 1000 Da or below, and the extracted traditional Chinese medicine extract and active small molecule polypeptide can permeate various eye tissue barriers to reach the eye fundus, and are suitable for various eye fundus diseases such as eye nebula barrier, eye dryness and soreness, visual fatigue, blurred vision and nyctalopia.

Description

Technical field [0001] The present invention belongs to the pharmaceutical field, and more particularly to an eye aqueous water and preparation method of a thermal plant active ingredient. Background technique [0002] In daily office, in life, with a large amount of popularity and extensive use of mobile phones, computers, TV and other electronic audiovisual equipment, many people are prone to excessive and incorrect use of eye, plus Ultra-ultraviolet, Blu-ray and other harmful lights to the eye's infringement, easily lead to eye disease, such as visual blur, visual cell damage, visual nerve atrophy, retinal macular dissemination. Because the hazards that can be generated such diseases are relatively large, it is necessary to see timely prevention and treatment in time. [0003] There are many nerve cells around the eyes, they are very susceptible to harm. Optical neurological atrophy is damage to various lesions of optic nerve and its myelin or retinal gangliocytes and its axon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/28A61K9/08A61K47/10A61P27/02A61P27/12C07K1/30C07K1/34C12P21/06A61K35/618A61K36/8984A61K38/01
CPCA61K38/012A61K38/28A61K36/8984A61K36/482A61K36/815A61K36/287A61K35/618A61K9/08A61K9/0048A61K47/10A61P27/02A61P27/12C12P21/06C07K1/30C07K1/34A61K2236/331A61K2300/00
Inventor 李宇宙李瀚韬周昱彤周志广李旭阳李欣喆周昱欣周艳峰
Owner 李宇宙
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