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Effervescent preparation of compound oral rehydration salt as well as preparation process and application of effervescent preparation

A technology of effervescent preparations and rehydration salts, which is applied in the fields of application, medical preparations containing active ingredients, and pill delivery, which can solve the problems of cumbersome taking procedures, large side effects, and large amount of drinking fluids, so as to improve immunity and improve Intestinal function, the effect of overcoming side effects

Active Publication Date: 2021-09-24
上海耀大生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The present invention provides an effervescent compound oral rehydration salt that simplifies the way of taking and has a good curative effect on diarrhea in order to overcome the defects of cumbersome taking procedure, large amount of drinking liquid, poor taste and large side effects when taking multiple medicines in combination. Preparation and its preparation process and application

Method used

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  • Effervescent preparation of compound oral rehydration salt as well as preparation process and application of effervescent preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] (1) The formula of the effervescent preparation of compound oral rehydration salt

[0061] The effervescent formulation of this compound ORS includes probiotics 1 x 10 9 CFU / g, 0.1 parts of prebiotics, 10.9 parts of rehydration salts, 58 parts of modified montmorillonite coated granules, and 31 parts of effervescent auxiliary materials. Specifically, it includes the following components;

[0062] Including rehydration salt components: 2.6 parts of sodium chloride, 1.2 parts of potassium chloride, 1.6 parts of citrate, and 5.5 parts of anhydrous glucose.

[0063] Including modified montmorillonite coating particle components: 34.5 parts of montmorillonite, 1.5 parts of sodium pyruvate, 0.5 parts of ethyl cellulose, 0.5 parts of chitosan, 1 part of acetyl ethyl citrate and PVP- K30 is 20 servings.

[0064] Including effervescent auxiliary material components: 5 parts of acid source, 5 parts of alkali source, 14 parts of filler, 2.7 parts of disintegrant, 2 parts of lub...

Embodiment 2

[0086] (1) The formula of the effervescent preparation of compound oral rehydration salt

[0087] The effervescent formulation of this compound ORS includes probiotics 1 x 10 9 CFU / g, 0.5 parts of prebiotics, 15.9 parts of rehydration salts, 48 ​​parts of modified montmorillonite coated granules, and 35.6 parts of effervescent auxiliary materials. Specifically, it includes the following components;

[0088] Including rehydration salt components: 4.5 parts of sodium chloride, 3 parts of potassium chloride, 2.3 parts of citrate, 6.1 parts of anhydrous glucose.

[0089] Including modified montmorillonite coating particle components: 30 parts of montmorillonite, 1 part of sodium pyruvate, 0.5 part of ethyl cellulose, 0.5 part of chitosan, 1 part of acetyl ethyl citrate and PVP- K30 is 15 servings.

[0090] Including effervescent auxiliary material components: 6 parts of acid source, 6 parts of alkali source, 16 parts of filler, 3.3 parts of disintegrant, 2 parts of lubricant, 0...

Embodiment 3

[0112] (1) The formula of the effervescent preparation of compound oral rehydration salt

[0113] The effervescent formulation of this compound ORS includes probiotics 1 x 10 9 CFU / g, 0.5 parts of prebiotics, 20.9 parts of rehydration salts, 39 parts of modified montmorillonite-coated granules, and 39.6 parts of effervescent auxiliary materials. Specifically, it includes the following components;

[0114] Including rehydration salt components: 6.5 parts of sodium chloride, 2.5 parts of potassium chloride, 2.8 parts of citrate, and 8.1 parts of anhydrous glucose.

[0115] Including modified montmorillonite coating particle components: 24 parts of montmorillonite, 0.5 part of sodium pyruvate, 0.5 part of ethyl cellulose, 0.5 part of chitosan, 0.5 part of acetyl ethyl citrate and PVP- K30 is 13 servings.

[0116] Including effervescent auxiliary material components: 7 parts of acid source, 7 parts of alkali source, 19 parts of filler, 3.3 parts of disintegrant, 1 part of lubri...

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Abstract

The invention discloses an effervescent preparation of compound oral rehydration salt as well as a preparation process and application of the effervescent preparation. The effervescent preparation comprises the following components in percentage by mass: 30-90% of a main medicine composition of rehydration salt, probiotics and modified montmorillonite coated particles and 10-70% of pharmaceutically acceptable effervescent auxiliary materials; and wherein the content of the probiotics is 10 < 6 >-10 < 10 > CFU / g, and the effervescent auxiliary materials comprise an acid source and an alkali source. According to the effervescent preparation of the compound oral rehydration salt, the rehydration salt, the probiotics and the modified montmorillonite coating particles are combined for use, and after the rehydration salt and the probiotics exert corresponding curative effects after orally taking the effervescent preparation, montmorillonite generates mucous membrane attachment, a continuous protection effect on gastrointestinal tracts is achieved, and the side effects caused by combined administration of rehydration salt, montmorillonite and other medicinal preparations are effectively overcome. The effervescent preparation can be used for effectively treating and relieving symptoms of urgent and severe patients needing the medicine to take effect quickly in time, is also particularly suitable for children, old people and patients who are difficult to take pills, and is convenient to carry and use.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations and relates to an oral liquid salt, in particular to an effervescent preparation of a compound oral rehydration salt and its preparation process and application. Background technique [0002] Oral rehydration salts are recommended by the World Health Organization as one of the first-choice drugs for treating diarrhea and dehydration. Oral rehydration is clinically used to treat and prevent dehydration caused by various reasons. Early oral rehydration is effective for non-severe dehydration and The maintenance treatment of severe dehydration can play a relatively obvious effect, and the effective rate is over 95%. Traditional diarrhea treatment, especially for pediatric patients, involves at least two or more preparations, complicated operation, large amount of drinking fluid, and salty taste of rehydration salt itself, which may lead to poor clinical compliance and long treatme...

Claims

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Application Information

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IPC IPC(8): A61K9/46
CPCA61K9/0007A61K9/2059A61K9/1652A61K33/14A61K33/00A61K31/194A61K31/7004A61K35/745A61K35/747A61K35/744A61K36/064A61K35/742A61K33/06A61K31/733A61K31/716A61K31/702A61K31/7016A61K9/5015A61K9/5047A61K9/5036A61K9/5026A61P1/12A61P1/00A23L33/135A23L33/16A23L33/125A23L33/10A23L33/21A23P10/30A23V2002/00A61K2300/00A23V2200/3204A23V2200/3202A23V2200/32A23V2250/61A23V2250/638Y02A50/30
Inventor 李小清蒋雅红顾珽李玉柱
Owner 上海耀大生物科技有限公司
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