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Anti-osteoporosis drug

An anti-osteoporosis and drug technology, applied in the field of anti-osteoporosis pain drugs, can solve unclear problems

Inactive Publication Date: 2021-09-24
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether Rehmannia glutinosa plays a role in alleviating chronic pain by regulating this signaling pathway is still unclear.

Method used

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Embodiment Construction

[0024] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them.

[0025] see Figure 1 to Figure 8 , the invention provides an anti-osteoporosis pain medicine, which mainly includes rehmannia glutinosa water extract and its main components.

[0026] Specifically include the following quality: rehmannia glutinosa water extract (2.5g / kg), preparation method and fingerprint: 1200 g rehmannia glutinosa decoction pieces are placed in a mortar with liquid nitrogen, ground into powder and divided into four equal parts. For each 300 g portion, add 3 L of distilled water to dissolve (continuous stirring at 4 °C for 72 hours). Then centrifuge at 4000 rpm for 10 minutes at 4°C, collect four supernatants and combine them, and co...

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PUM

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Abstract

The invention discloses an anti-osteoporosis drug, relates to the technical field of research and development of anti-osteoporosis drugs, and particularly relates to an anti-osteoporosis drug. The anti-osteoporosis drug comprises a prepared rehmannia root water extract and main monomer components thereof, namely echinacoside, rehmannioside, verbascoside, scorch-fried rehmannioside, isophenoside, verbascoside, catalpol, rehmannioside A, rehmannioside B, rehmannioside D, Rehmaionoside A, Rehmaionoside B, Rehmaionoside C, rehmanniin A, rehmanniin B, rehmanniin D, rehmanniin C, leonuride, rehmannioside D, geniposide, gentisic acid, apigenin, oleanolic acid, polysaccharide and reducing sugar, and derivatives of the components. In the anti-osteoporosis drug, the prepared rehmannia root water extract can prolong the reaction time of photothermal pain of ovarian estrogen deprived rats, can increase the mechanical touch-induced pain threshold of the ovarian estrogen deprived rats, and can reduce formalin inflammatory pain of the ovarian estrogen deprived rats.

Description

technical field [0001] The invention relates to the technical field of research and development of anti-osteoporosis pain medicine, in particular to an anti-osteoporosis pain medicine. Background technique [0002] With the arrival of menopause, the level of estrogen in women drops significantly, and the body's sensitivity to pain increases significantly. This seriously affects the quality of life of the perimenopausal population. At the same time, some anti-osteoporosis products on the market may have the effect of relieving osteoporosis pain. However, these products may have some degree of side effects, such as endometrial hyperplasia, rash, diarrhea, flu-like symptoms, ulcerative stomatitis, and so on. For this reason, new anti-osteoporosis pain products are urgently needed in the market. [0003] According to the theory of traditional Chinese medicine, Rehmannia glutinosa has the effects of nourishing yin and blood, replenishing essence and filling marrow, and has a p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804G01N30/02A61K31/7048A61K31/7034A61K31/352A61K31/192A61K31/56A61K31/715A61K31/7016A61K31/7004A61P19/10A61P29/00
CPCA61K36/804G01N30/02A61K31/7048A61K31/7034A61K31/352A61K31/192A61K31/56A61K31/715A61K31/7016A61K31/7004A61P19/10A61P29/00A61K2236/331
Inventor 张东伟贾强强王丽丽张浩朱如愿陈贝贝赵丹丹高思华
Owner BEIJING UNIV OF CHINESE MEDICINE
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