Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition comprising GLP-1 receptor agonist and glucagon receptor agonist and uses thereof

一种胰高血糖素、受体激动剂的技术，应用在减肥和/或降脂领域，能够解决活性差、半衰期短等问题，达到促进体重减轻、食物摄取减少、减少体重增加的效果

Pending Publication Date: 2021-10-01
PEGBIO
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the half-life of oxyntomodulin in human plasma is very short (8-12 minutes); as a dual-receptor agonist, its activity is poor, and its ability to activate two receptors is much lower than that of the original peptide. The dosage needs to reach the level of mg / kg

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition comprising GLP-1 receptor agonist and glucagon receptor agonist and uses thereof
  • Composition comprising GLP-1 receptor agonist and glucagon receptor agonist and uses thereof
  • Composition comprising GLP-1 receptor agonist and glucagon receptor agonist and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Example 1: Preparation of PB-119 (a conjugate of PB-105 and mPEG-ppMAL-23KD)

[0091] Weigh 10mg of PB-105 (purchased from Chengdu Capgemini Biomedical Technology Development Co., Ltd.) and 65mg of mPEG23KD-ppMAL (produced by Paige Biopharmaceutical Company) in a 50mL glass container bottle (the molar ratio of PB-105 to PEG is 1:1.2 ), dissolved in 5ml of 0.2M PBS buffer solution with pH 6.5, and stirred at room temperature (25°C) for 1 hour, then adjusted the pH to 4.0 with hydrochloric acid to terminate the reaction, and placed at 4°C for purification.

[0092] Dilute the above reaction solution 5 times with ultrapure water, adjust the pH to 4.0 with acetic acid, and load the sample on the cation exchange of 10 mL Macrocap SP equilibrated with buffer A (20 mM pH 4.0 HAc-NaAc) for 3-4 column volumes. Column, after loading, use buffer A (20mM pH 4.0 HAc-NaAc) to elute excess PEG, then use eluent B (20mM pH4.0 HAc-NaAc+1M NaCl) to elute 10 column volume gradients When t...

Embodiment 2

[0093] Example 2: Preparation of PB-120 (a conjugate of PB-105 and mPEG-ppMAL-25KD)

[0094] Weigh 10mg of PB-105 (purchased from Chengdu Capgemini Biomedical Technology Development Co., Ltd.) and 72mg of mPEG25KD-ppMAL (produced by Paige Biopharmaceutical Company) in a 50mL glass container bottle (the molar ratio of PB-105 to PEG is 1:1.2 ), dissolved in 5ml of 0.2M PBS buffer solution with pH 6.5, and stirred at room temperature (25°C) for 1 hour, then adjusted the pH to 4.0 with hydrochloric acid to terminate the reaction, and placed at 4°C for purification.

[0095] Dilute the above reaction solution 5 times with ultrapure water, adjust the pH to 4.0 with acetic acid, and load the sample on the cation exchange of 10 mL Macrocap SP equilibrated with buffer A (20 mM pH 4.0 HAc-NaAc) for 3-4 column volumes. Column, after loading, use buffer A (20mM pH 4.0 HAc-NaAc) to elute excess PEG, then use eluent B (20mM pH4.0 HAc-NaAc+1M NaCl) to elute 10 column volume gradients When t...

Embodiment 3

[0096] Example 3: Preparation of PB-107 (a conjugate of PB-105 and mPEG-ppMAL-30KD)

[0097] Weigh 10mg of PB-105 (purchased from Chengdu Capgemini Biomedical Technology Development Co., Ltd.) and 86mg of mPEG30KD-ppMAL (produced by Paige Biopharmaceutical Company) in a 50mL glass container bottle (the molar ratio of PB-105 to PEG is 1:1.2 ), dissolved in 5ml of 0.2M PBS buffer at pH 6.5, and stirred at room temperature (25°C) for 1 hour, then adjusted to pH 4.0 with hydrochloric acid to terminate the reaction, and placed at 4°C for purification.

[0098] Dilute the above reaction solution 5 times with ultrapure water, adjust the pH to 4.0 with acetic acid, and load the sample on the cation exchange of 10 mL Macrocap SP equilibrated with buffer A (20 mM pH 4.0 HAc-NaAc) for 3-4 column volumes. Column, after loading, use buffer A (20mM pH 4.0 HAc-NaAc) to elute excess PEG, then use eluent B (20mM pH4.0 HAc-NaAc+1M NaCl) to elute 10 column volume gradients When the elution reac...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a composition comprising a GLP-1 receptor agonist and a glucagon receptor agonist and uses thereof. In particular, the present invention relates to a pharmaceutical composition comprising a pharmaceutically effective amount of the GLP-1 receptor agonist and a glucagon receptor agonist, wherein the GLP-1 receptor agonist and the glucagon receptor agonist each independently form a conjugate with a hydrophilic polymer or the GLP-1 receptor agonist and the glucagon receptor agonist together form a conjugate with a hydrophilic polymer.

Description

[0001] This application is a branch of the invention with the application date of December 29, 2015, the title of the invention is "composition comprising a GLP-1 receptor agonist and a glucagon receptor agonist and its use", and the application number is 201511017796.2. case application. technical field [0002] The present invention relates to the field of medicine. In particular, the present invention relates to a composition comprising a GLP-1 receptor agonist and a glucagon receptor agonist and its use for weight loss and / or lipid lowering. Background technique [0003] With the changes in diet and lifestyle brought about by economic development in recent years, the proportion of obese people has increased year by year. According to the latest statistics from the World Health Organization: the number of obese and overweight people in the world has surged from 857 million in 1980 to 2.1 billion in 2013, accounting for nearly one-third of the world's total population. I...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/26A61K47/58A61K47/59A61K47/60A61K47/61A61K47/64A61P1/16A61P3/04A61P3/06
CPCA61K38/17A61K38/1767A61K38/26A61K45/06A61K2300/00A61P3/04A61P3/06A61P3/10Y02A50/30A61K47/60A61P1/16A61K38/2278
Inventor 徐敏张映辉
Owner PEGBIO
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com