Phenylacetic acid synthesis method

Abstract

The invention discloses a phenylacetic acid synthesis method, and belongs to the technical field of chemical synthesis. The phenylacetic acid synthesis method comprises the following steps: S1, raw materials preparing: preparing benzyl chloride, sodium hydroxide, carbon monoxide, hydrochloric acid, toluene and a catalyst; S2, raw material mixing: pre-mixing benzyl chloride, sodium hydroxide, toluene and the catalyst, and then adding the catalyst for mixing; and S3, synthesis: preheating the mixed material, and then feeding the preheated material into a multi-stage reaction tower for carbonylation reaction. By arranging the multi-stage series reaction tower, carbon monoxide is recycled in the synthesis reaction process, so that the carbon monoxide is fully utilized, and the synthesis reaction rate is increased.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to a method for synthesizing phenylacetic acid. Background technique [0002] Phenylacetic acid is an important intermediate of fine chemicals such as pharmaceuticals and spices, belonging to the category of fine chemicals. In medicine, phenylacetic acid is mainly used to produce penicillin, and is also used to prepare sedative and antidepressant amitriptyline, and epilepsy drug phenobarbital. In industry, phenylacetic acid is often used in the preparation of high-performance engineering plastic curing agents, fluorescent whitening agents, fuels, and display agents for photosensitive materials. In addition, in terms of spices, phenylacetic acid is an edible spice that is allowed to be used in my country, and is mainly used in the production of food, detergents, cleaning agents, cosmetics, tobacco, and beverages. [0003] There are dozens of production methods of phenyla...

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Problems solved by technology

[0004] Sodium cyanide method (phenylacetonitrile hydrolysis method) uses toluene as raw material, passes chlorine to produce benzyl chloride, reacts with sodium cyanide to generate phenylacetonitrile, and then undergoes hydrolysis and acidification to obtain phenylacetic acid. This process is a relatively traditional and mature process in China. The method is characterized in that the process is simple and the yield of the hydrolysis process is high; the disadvantage is that the cost is high and the total yield is low; the production of phenylacetic acid by the carbonylation method, the materials in the synthesis reaction step include benzyl chloride, sodium hydroxide, toluene, water, catalyst and Carbon monoxide, there is an immiscible gas (carbon monoxide)-liquid (water and sodium hydroxide)-liquid (benzyl chloride and toluene) three-phase and catalyst, only when fully mixed can the reaction occur, and the existing synthetic method is not very good Solve the mixing problem effectively and affect the carbon monoxide utilization rate and synthesis reaction rate

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