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Method for preparing polyvinylpolypyrrolidone

A technology of cross-linked povidone and cross-linking agent is applied in the field of preparing cross-linked povidone, which can solve the problems of unsatisfactory yield, side reaction, lack of competitiveness, etc., and achieves improvement in quality, particle size, and market. The effect of competitiveness

Inactive Publication Date: 2021-10-01
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the traditional method of producing crospovidone generally uses NaOH, purified water, and NVP to produce crospovidone through popcorn polymerization, but this method will produce side reactions in the process, and the yield cannot meet the current situation gradually. There is industry development and lack of competitiveness in the existing market

Method used

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  • Method for preparing polyvinylpolypyrrolidone
  • Method for preparing polyvinylpolypyrrolidone
  • Method for preparing polyvinylpolypyrrolidone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] refer to figure 1 , image 3 , Figure 6 , a method for preparing crospovidone, the process is as follows: NVP, water, and NaOH are put into the reaction kettle according to mass fractions of 100g, 15.1g, and 1g respectively, and then 1.0g of crosslinking agent is added, and replaced with nitrogen to remove Oxygen in the bottle, turn on the stirrer and heat to 140°C under the protection of nitrogen at 0.2MPa pressure, keep it warm for 190min, observe the obvious temperature rise on the thermometer, indicating that the reaction has started, until the temperature no longer rises, indicating that the popcorn polymerization reaction is over , the temperature was lowered to 70° C. by cooling water, the product was taken out, washed with water and dried to obtain a crospovidone product with a yield of 92.2%.

Embodiment 2

[0028] A method for preparing crospovidone, the process is as follows:

[0029] Put NVP, water, and NaOH into the reaction kettle according to the mass fraction of 100g, 15.1g, and 1.0g respectively, then add 1.0g of crosslinking agent, replace with nitrogen to remove the oxygen in the bottle, and turn on the stirrer under 0.2MPa pressure of nitrogen Heated to 135°C under protection and kept warm for 190min. Observing a significant temperature rise on the thermometer indicates that the reaction has begun. When the temperature stops rising, it indicates that the popcorn polymerization reaction is over. Cool the temperature to 70°C with cooling water, take out the product, wash and dry dry to obtain a crospovidone product with a yield of 88.4%.

Embodiment 3

[0031] A method for preparing crospovidone, the process is as follows:

[0032] Put NVP, water, and NaOH into the reaction kettle according to the mass fraction of 100g, 15.1g, and 1.0g respectively, then add 1.0g of crosslinking agent, replace with nitrogen to remove the oxygen in the bottle, and turn on the stirrer under 0.2MPa pressure of nitrogen Heating to 130°C under protection, keeping it warm for 190min, observing that the temperature rises obviously on the thermometer indicates that the reaction has started, until the temperature no longer rises, indicating that the popcorn polymerization reaction is over, cool down to 70°C with cooling water, take out the product, wash and dry dry to obtain a crospovidone product with a yield of 95%.

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Abstract

The invention relates to a method for preparing cross-linked povidone, which comprises the following steps: respectively putting 50-90% by mass of NVP, 15.5-26.8% by mass of water and 0.45-1.6% by mass of NaOH into a reaction kettle, then adding a cross-linking agent, replacing with nitrogen to remove oxygen in a bottle, starting a stirrer, heating to 110-150 DEG C under the protection of nitrogen under the pressure of 0.1-0.5 MPa, keeping the temperature for 150-230 minutes, observing that the temperature of a thermometer is obviously increased, namely that the reaction is started, and taking out the product after the popcorn polymerization reaction is finished until the temperature does not rise any more, washing and drying. The method provided by the invention has the characteristic of large particle size of the product.

Description

technical field [0001] The invention relates to a method for preparing crospovidone. Background technique [0002] Crospovidone (PVPP) product is a super absorbent resin with strong water absorption and water retention capacity. Its water absorption capacity can reach several times or even dozens of times its own weight, and hydrogen bonds can be formed between the substrate and the adsorbed water, so that the adsorbed water will not be lost even under a certain pressure. PVPP with a high degree of cross-linking is insoluble in water and has relatively poor water absorption capacity, so it can be recycled and reused. PVPP has excellent characteristics such as physiological safety, water absorption, water insolubility, and complexation, and has broad application prospects in the fields of medicine, food, and cosmetics. [0003] At present, the traditional method of producing crospovidone generally uses NaOH, purified water, and NVP to produce crospovidone through popcorn po...

Claims

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Application Information

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IPC IPC(8): C08F26/10
CPCC08F26/10
Inventor 欧阳密林泓见张诚孙鹏
Owner ZHEJIANG UNIV OF TECH
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