Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

In-situ injectable anti-adhesion gel and preparation method thereof

An anti-adhesion and gel technology, which is applied in medical formula, medical science, surgery, etc., can solve the problems of difficult control of hydrogel uniformity and time-consuming, and achieve no harmful substance residue, less energy consumption, and safe raw materials Effect

Inactive Publication Date: 2021-10-22
QINGDAO CHENLAND MARINE BIOTECH CO LTD
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The carboxyl activator EDC or NHS is used in the preparation of the multifunctional hydrogel, which involves the removal of activator residues, and the carboxyl activation needs to be carried out for 4 hours, which is relatively time-consuming
In addition, the influence of the mixing mode and speed during the mixing of solution a and solution b should be considered, and the uniformity of the formed hydrogel is not easy to control

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • In-situ injectable anti-adhesion gel and preparation method thereof
  • In-situ injectable anti-adhesion gel and preparation method thereof
  • In-situ injectable anti-adhesion gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A method for preparing an in-situ injectable anti-adhesion gel, specifically comprising the steps of:

[0037] 1) Weigh 97.0 g of water, then add 2.0 g of sodium alginate and 1.0 g of gluconolactone under stirring at 700 rpm, and stir for 30 min until they are completely dissolved to obtain a homogeneous solution A.

[0038]2) Weigh 0.04g of calcium sulfate and 0.03g of disodium ethylenediaminetetraacetate, add to 20.0g of water and stir to dissolve to obtain solution B.

[0039] 3) After the above solution A and solution B are prepared, they are filled with a double three-way injection device. The two needles are filled with 2mL of solution A and 1mL of solution B respectively. Anti-adhesion gel sterile product.

Embodiment 2

[0041] A method for preparing an in-situ injectable anti-adhesion gel, specifically comprising the steps of:

[0042] 1) Weigh 97.0 g of water, then add 2.0 g of sodium alginate and 1.0 g of gluconolactone under stirring at 700 rpm, and stir for 30 min until they are completely dissolved to obtain a homogeneous solution A.

[0043] 2) Weigh 0.02g of calcium sulfate and 0.015g of disodium ethylenediaminetetraacetate, add to 20.0g of water and stir to dissolve to obtain solution B.

[0044] (8) 3) After the above-mentioned solution A and solution B are prepared, they are filled with a double three-way injection device. The two needle tubes are filled with 3mL of solution A and 2mL of solution B respectively. An injectable anti-adhesion gel sterile product.

Embodiment 3

[0046] A method for preparing an in-situ injectable anti-adhesion gel, specifically comprising the steps of:

[0047] 1) Weigh 97.3g of water, then add 1.8g of sodium alginate and 0.9g of gluconolactone under stirring at 600rpm, and stir for 25min until they are completely dissolved to obtain a homogeneous solution A.

[0048] 2) Weigh 0.02g of calcium chloride and 0.015g of disodium ethylenediaminetetraacetate, add to 20.0g of water and stir to dissolve to obtain solution B.

[0049] 3) After the above-mentioned solution A and solution B are prepared, they are filled with a double three-way injection device. The two needles are filled with 3mL of solution A and 2mL of solution B respectively. Anti-adhesion gel sterile product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses in-situ injectable anti-adhesion gel and a preparation method thereof, and belongs to the field of anti-adhesion of medical instruments. In combination with a duplex three-way injection device, the anti-adhesion gel can be injected into a target position in a solution form during use in an injection manner, the gel is rapidly formed in situ while being pushed and mixed and contacted, and the uniform and stable gel can be rapidly obtained to act on the target position without other auxiliary measures; the problem that the sodium alginate is not beneficial to being accurately injected to a target position due to too high strength after the sodium alginate forms gel in vitro is solved. The raw materials used by the in-situ injectable anti-adhesion gel disclosed by the invention are safe, and no harmful substance is left in the whole cross-linking preparation process, so that the safety of the product in the use process is ensured, and postoperative adhesion is effectively prevented; and the preparation process is simple, low in energy consumption, short in time consumption and easy to realize industrialization.

Description

technical field [0001] The invention belongs to the field of anti-adhesion of medical devices, and in particular relates to an in-situ injectable anti-adhesion gel and a preparation method thereof. Background technique [0002] Postoperative tissue adhesions are abnormal structures formed during surgery where fibrous bands of connective tissue combine with adjacent tissues or organs due to tissue trauma, that is, internal scar tissue formed after surgery that connects originally discontinuous organs / tissues , is a common pathological reaction. Postoperative adhesions are very common, such as abdominal, pelvic, and tendon adhesions after abdominal surgery, gynecological surgery, and orthopedic tendon surgery. Adhesion is still an unavoidable postoperative complication, which will affect the physiological and mechanical functions of the body's organs. Certain damage. [0003] In recent years, one of the effective measures to prevent adhesions is to establish a physical barri...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L31/04A61L31/02A61L31/14
CPCA61L31/042A61L31/028A61L31/145A61L31/14A61L2400/06
Inventor 王宝群苏晓明邹圣灿刘桂亭林莎莎
Owner QINGDAO CHENLAND MARINE BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com