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Synthesis method of metamifop

A technology of oxazolam and a synthesis method, applied in the field of organic molecule synthesis, can solve the problems of many three wastes, high cost, low product purity and the like, and achieve the effects of high purity, reduced production cost and simple operation

Pending Publication Date: 2021-11-09
JIANGSU FUDING CHEM
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] To sum up, the existing synthetic methods of fenpyramid have their own disadvantages, such as high cost, many wastes, and low purity of the obtained product

Method used

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  • Synthesis method of metamifop
  • Synthesis method of metamifop
  • Synthesis method of metamifop

Examples

Experimental program
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Effect test

Embodiment 1

[0041] A kind of synthetic method of fenpyramid, the steps are as follows:

[0042] Step (1), in a 500ml four-necked bottle, add 57.5g of water and 76.5g of potassium hydroxide, stir and dissolve at 30°C, then put in 41.5g of R-2-(4-hydroxyphenoxy)propionic acid (Formula I) , heated up to 40°C, and kept at normal pressure for 2 hours to generate R-2-(4-hydroxyphenoxy)propionic acid potassium salt (formula II), and the conversion of R-2-(4-hydroxyphenoxy)propionic acid The rate is 100%; then add dropwise a mixture of 48 g of 2,6-dichlorobenzoxazole and 57.5 g of acetone in a four-necked bottle, and react under normal pressure at 50 to 53°C for 2 hours, R-2-(4-hydroxybenzene The conversion rate of oxy)propionate potassium salt is 98%, and the acetone is removed under negative pressure, and then suction filtered to obtain 81g of filter cake, which is 2-(4-((6-chlorobenzo[d]oxazole-2- Base) oxy) phenoxy) propionic acid potassium salt (formula III), yield 96%.

[0043]

[0044...

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Abstract

The invention discloses a method for synthesizing metamifop, which comprises the following steps: reacting R-2-(4-hydroxyphenoxy) propionic acid with potassium hydroxide to generate R -2-(4-hydroxyphenoxy) propionic acid potassium salt; reacting 2, 6-dichlorobenzoxazole with the R -2-(4-hydroxyphenoxy) propionic acid potassium salt to generate 2-(4-((6-chlorobenzo [d] oxazole)-2-yl) oxy) phenoxy) propionic acid potassium salt, reacting the 2-(4-((6-chlorobenzo [d] oxazole)-2-yl) oxy) phenoxy) propionic acid potassium salt with hydrochloric acid to generate 2-(4-((6-chlorobenzo [d] oxazole)-2-yl) oxy) phenoxy) propionic acid, carrying out an acylating chlorination reaction to generate 2-(4-((6-chlorobenzo [d] oxazole)-2-yl) oxy) phenoxy) propionyl chloride, and further carrying out amidation reaction on the product and N-methyl-2-fluoroaniline to generate the metamifop. The total yield of the method is about 87%, and the method is suitable for industrial mass production.

Description

technical field [0001] The invention belongs to the field of organic molecule synthesis, and relates to a method for synthesizing fenpyramid. Background technique [0002] Herbicides refer to agents that can completely or selectively kill weeds, also known as herbicides, and are a class of substances used to eliminate or inhibit plant growth. The development of herbicides in the world is gradually stabilizing, mainly developing varieties with high efficiency, low toxicity, broad spectrum, and low dosage, and disposable treatment agents with little environmental pollution have gradually become the mainstream. [0003] The chemical name of fenpyramid is: (R)-2-[4-(6-chloro-1,3-benzoxazol-2-yloxy)phenoxy]-N-(2-fluorobenzene base)-N-methylpropionamide, English name: (R)-2-[4-(6-Chlorobenzo[d]oxazol-2-yloxy)phenoxy]-N-(2-fluorophenyl)-N-methylpropionamide. The chemical structure is shown in formula VI: [0004] [0005] Mefenpyramid is an aryloxyphenoxypropionate (AOPP) her...

Claims

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Application Information

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IPC IPC(8): C07D263/58A01P13/00
CPCC07D263/58C07B2200/07
Inventor 常青朱跃波张彦飞
Owner JIANGSU FUDING CHEM
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