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Antifungal polypeptide mouthwash and preparation method thereof

A mouthwash and antifungal technology, applied in antifungal agents, topical antibacterial agents, peptides, etc., can solve the problems of increased drug resistance reports, large toxic and side effects of anti-Candida albicans drugs, and many adverse reactions, achieving no toxic and side effects and adverse reactions, inhibiting the proliferation of Candida albicans, and inhibiting the effect of oral ulcers

Pending Publication Date: 2021-11-12
NINGXIA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although new antifungal drugs are constantly coming out, which provide new opportunities for antifungal treatment, anti-Candida albicans drugs have the disadvantages of large toxic and side effects and many adverse reactions, and reports of drug resistance are gradually increasing

Method used

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  • Antifungal polypeptide mouthwash and preparation method thereof
  • Antifungal polypeptide mouthwash and preparation method thereof
  • Antifungal polypeptide mouthwash and preparation method thereof

Examples

Experimental program
Comparison scheme
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Embodiment

[0017] Main reagent formula of the present invention comprises:

[0018] (1) LB medium: each liter contains 10g peptone, 5g yeast extract, 5g NaCl, autoclaved, stored at room temperature;

[0019] (2) LB / IPTG / Xgal plate: LB medium + 15g / L agar powder. Autoclave, cool to below 70°C, add 1mL IPTG / Xgal, mix well and pour plate. Store the plate in the dark at 4°C;

[0020] (3) Top agar: Each liter contains 10g peptone, 5g yeast extract, 5g NaCl, and 7g agar powder. Autoclave, divide into 50ml aliquots, store the solid medium at room temperature, and melt it in a microwave oven when used;

[0021] (4) Tetracycline stock solution: dissolve in 70% ethanol at a concentration of 20 mg / mL, store at -20°C in the dark, and shake well before use;

[0022] (5) LB-Tet plate: LB medium + 15g / L agar powder. Autoclave, when cooled to below 70°C, add 1mL of tetracycline stock solution, mix well and pour plate, and store the plate in the dark at 4°C;

[0023] (6) PEG8000 / NaCl: 20% (w / v) PEG...

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Abstract

The invention discloses antifungal polypeptide mouthwash. The antifungal polypeptide mouthwash is prepared from polypeptide A and polypeptide B, wherein the amino acid sequence of the polypeptide A is Lys-Arg-Leu-Phe-Lys-Lys-Leu; the amino acid sequence of the polypeptide B is Asp-Leu-Ile-Trp-Lys-Leu-Leu. The antifungal polypeptide mouthwash disclosed by the invention can be used for inhibiting the proliferation of candida albicans and also has a certain anti-inflammatory effect; the antifungal polypeptide mouthwash has no danger of abuse of antibiotics, does not damage the survival of other beneficial florae which are originally planted in an oral cavity or a respiratory tract, and has no toxic side effect and adverse reaction; and the oral cavity is prevented and protected through a small-molecular polypeptide method and the generation of oral ulcer can be effectively inhibited.

Description

technical field [0001] The invention relates to an antifungal polypeptide mouthwash and a preparation method thereof. Background technique [0002] Oral mucosal disease (OMD), also known as soft tissue oral disease, is described as a family of diseases or conditions that affect the oral mucosa and soft tissues. The most common and difficult to cure oral mucosal diseases is recurrent oral ulcers caused by oral candidiasis (OC) infection. So far, many literatures and studies have confirmed that Candida albicans is the main pathogen of oral candidiasis infection causing recurrent oral ulcers. [0003] The current treatment for Candida albicans infection mainly revolves around the use of antibiotics, and due to the abuse of antibiotics in recent years, many antibiotics also destroy other beneficial flora that originally colonized the oral cavity or respiratory tract in the process of inhibiting Candida albicans The breakdown of this microbial dynamic balance makes the incidenc...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/67A61K8/63A61P31/02A61P31/10A61P29/00A61Q11/00C07K7/06
CPCA61K8/64A61K8/676A61K8/63A61Q11/00A61P31/02A61P31/10A61P29/00C07K7/06A61K2800/5922
Inventor 周学章乔亚蕊秦希曦薛頔林雪
Owner NINGXIA UNIVERSITY
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