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Pharmaceutical composition injectable into urinary track organ cavity for prevention or treatment of urothelial cancer

A technique for urinary organs and drugs, applied in the field of pharmaceutical compositions for the prevention or treatment of urothelial carcinoma, to achieve the effects of less damage, high selectivity, and improved therapeutic effect

Pending Publication Date: 2021-11-12
KAGAWA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in BCG injection therapy, harmful phenomena such as bladder irritation still occur frequently, and there are many cases of non-recovery, which has become a problem, and drugs with higher tolerance are required.

Method used

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  • Pharmaceutical composition injectable into urinary track organ cavity for prevention or treatment of urothelial cancer
  • Pharmaceutical composition injectable into urinary track organ cavity for prevention or treatment of urothelial cancer
  • Pharmaceutical composition injectable into urinary track organ cavity for prevention or treatment of urothelial cancer

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Experimental program
Comparison scheme
Effect test

Embodiment

[0065] Next, the present invention will be described in more detail using examples. However, the present invention is not limited thereto.

[0066] (Example)

[0067] [Analysis of antitumor effects of rare sugars on human urothelial carcinoma cell lines]

[0068] Using three human urothelial carcinoma cell lines (RT112, 253J, J82), the antitumor effect of rare sugars was analyzed. As rare sugars, L-psicose, D-psicose, D-allose, L-fructose, D-mannose, L-sorbose, D-tagatose, D-galactose, There are 10 types of D-sorbose and L-tagatose, and D-glucose and D-fructose are used as monosaccharides that are not rare sugars.

[0069] [used culture medium]

[0070] Medium uses the minimum essential medium (MEM) that contains D-glucose 1000mg / l, utilizes the MEM [by (10), (25) adjusted in the mode containing each monosaccharide or each rare sugar 10mM, 25mM, 50mM ), (50) said. ], to evaluate the antitumor effect of rare sugars. In addition, as a control, no sugar was added to MEM.

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Abstract

Problem: To provide a pharmaceutical composition for prevention or treatment of urinary track organ cancer. The composition does not cause a problem with respect to side effects, can be continually used for an extended period of time, and is administered to a urinary track organ by injection into a cavity of the urinary track organ. Solution: a solution configured to be injected into a cavity of a urinary track organ, the solution containing D-allose. The urinary track organ cavity is inside the upper urinary tract and inside the bladder. The solution is for injection therapy where the solution is injected into a cavity of a urinary track organ, and for utilization of increase in D-allose sugar intake into urinary track organ cancer cells (e.g. RT112, 253J, J82). The solution contains D-allose together with a pharmaceutically acceptable dilution agent or support. This pharmaceutical composition is for prevention or treatment of cancers in a urinary track organ.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing an effective amount of D-allose for preventing or treating urothelial carcinoma by injecting it into the cavity of a urinary organ. Background technique [0002] Urine produced by the kidneys is excreted into the renal pelvis, and then sent to the bladder via the urinary catheter. Then, when a certain amount of urine accumulates in the bladder, the urge to urinate occurs, and the muscles of the bladder contract to expel it from the body. Urothelial carcinoma is a cancer that develops in the renal pelvis, ureter, and bladder, which are passageways of the urine. About 70% of them are considered to be non-muscle invasive, and their treatment includes injecting BCG (Bacillus Calmette-Guerin) or anticancer agents into the cavity of the urinary organ as a standard treatment in addition to transurethral surgery. However, the 5-year recurrence rate after the injection therapy using the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/047A61K31/7004A61K31/7008A61K31/7012A61K31/704A61K45/00A61P13/02A61P13/10A61P13/12A61P35/00A61P43/00A61K9/08A61K47/54
CPCA61P43/00A61K31/7008A61P13/02A61P13/12A61P35/00A61K31/704A61P13/10A61K31/7004A61K9/0034A61K9/0019A61K45/06A61K47/55A61K2300/00
Inventor 田冈利宜也笕善行杉元干史张霞松冈祐贵何森健吉原明秀
Owner KAGAWA UNIVERSITY
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